SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zcn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		5 / 12 ILE A 141
PHE A 140
LEU A 179
LEU A  76
ILE A 144
 None
 0.97A 4m2xA-2zcnA:
undetectable		 4m2xA-2zcnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		5 / 11 ILE A 141
LEU A 135
PHE A 140
LEU A  76
ILE A 144
 None
 1.01A 5z6mA-2zcnA:
undetectable		 5z6mA-2zcnA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		4 / 7 THR A  21
LEU A  12
ILE A  10
THR A  11
 None
 1.02A 5zsfA-2zcnA:
undetectable
5zsfB-2zcnA:
undetectable		 5zsfA-2zcnA:
17.49
5zsfB-2zcnA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		4 / 6 PHE A 147
VAL A 181
LEU A 135
LEU A 143
 None
 0.99A 6e43A-2zcnA:
undetectable		 6e43A-2zcnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		4 / 6 PHE A 147
VAL A 181
LEU A 135
LEU A 143
 None
 1.00A 6e43B-2zcnA:
3.0		 6e43B-2zcnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		4 / 6 PHE A 147
VAL A 181
LEU A 135
LEU A 143
 None
 0.98A 6e43C-2zcnA:
2.7		 6e43C-2zcnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zcn BIOFILM OPERON
ICAABCD HTH-TYPE
NEGATIVE
TRANSCRIPTIONAL
REGULATOR ICAR
(Staphylococcus
epidermidis) 		4 / 6 PHE A 147
VAL A 181
LEU A 135
LEU A 143
 None
 1.04A 6e43D-2zcnA:
1.8		 6e43D-2zcnA:
17.89