SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zcv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		4 / 5 TYR A 140
SER A  73
THR A 102
ASN A 137
 NDP  A 400 (-3.8A)
NDP  A 400 (-3.4A)
None
None
 1.38A 1yvpA-2zcvA:
undetectable		 1yvpA-2zcvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		5 / 12 ASN A  89
LEU A  59
ALA A  90
LEU A  71
LEU A 125
 None
 1.40A 2aa6B-2zcvA:
undetectable		 2aa6B-2zcvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		3 / 3 ARG A 171
VAL A  77
GLY A 113
 NDP  A 400 (-4.1A)
None
None
 0.57A 2avvE-2zcvA:
undetectable		 2avvE-2zcvA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		5 / 12 ASN A  89
LEU A  59
ALA A  90
LEU A  71
LEU A 125
 None
 1.40A 2oaxD-2zcvA:
undetectable		 2oaxD-2zcvA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		5 / 12 ARG A  49
ILE A  16
GLY A   9
ALA A  30
VAL A  29
 None
None
NDP  A 400 (-2.9A)
None
None
 0.95A 2oc8A-2zcvA:
undetectable		 2oc8A-2zcvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		4 / 7 SER A  73
LEU A 105
LEU A 104
THR A 102
 NDP  A 400 (-3.4A)
None
None
None
 0.88A 3cfqA-2zcvA:
undetectable
3cfqB-2zcvA:
undetectable		 3cfqA-2zcvA:
16.78
3cfqB-2zcvA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		5 / 12 LEU A 112
ALA A 161
GLY A 164
GLY A 250
ASP A 246
 None
 1.26A 3ou7D-2zcvA:
5.2		 3ou7D-2zcvA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		5 / 12 LEU A  71
TYR A 101
ILE A  88
ALA A  81
HIS A  84
 None
 1.08A 3uj7A-2zcvA:
5.2		 3uj7A-2zcvA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2zcv UNCHARACTERIZED
OXIDOREDUCTASE YTFG
(Escherichia
coli) 		5 / 12 LEU A 256
LEU A  11
ALA A 178
ALA A 175
TYR A 174
 None
NDP  A 400 (-4.0A)
None
None
None
 1.05A 3vw7A-2zcvA:
undetectable		 3vw7A-2zcvA:
19.92