SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zcw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY
(Thermus
thermophilus) 		4 / 5 LEU A 190
ALA A 124
LEU A 193
SER A 196
 None
 1.09A 1tt6B-2zcwA:
undetectable		 1tt6B-2zcwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 LEU A 187
LEU A 190
LEU A 193
ALA A 194
LEU A 129
 None
 0.84A 1ya3C-2zcwA:
undetectable		 1ya3C-2zcwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY
(Thermus
thermophilus) 		4 / 6 GLU A 192
ALA A 124
ASN A 120
ALA A 123
 None
 1.20A 2zgwB-2zcwA:
undetectable		 2zgwB-2zcwA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 VAL A 142
LEU A 151
ALA A 146
LEU A 134
ALA A 125
 None
 1.22A 4x1kA-2zcwA:
undetectable
4x1kB-2zcwA:
undetectable		 4x1kA-2zcwA:
19.20
4x1kB-2zcwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY
(Thermus
thermophilus) 		5 / 12 GLY A 156
LEU A 126
LEU A 127
GLU A 128
LEU A 129
 None
 1.05A 5nwwA-2zcwA:
undetectable		 5nwwA-2zcwA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zcw TRANSCRIPTIONAL
REGULATOR, FNR/CRP
FAMILY
(Thermus
thermophilus) 		3 / 3 ARG A  50
LEU A  37
PHE A  71
 None
 0.78A 6nknP-2zcwA:
undetectable		 6nknP-2zcwA:
21.74