SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ze3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ze3 DFA0005
(Deinococcus
ficus) 		4 / 8 ALA A 134
GLY A  86
ALA A 135
THR A  97
 None
 0.72A 1gtnI-2ze3A:
undetectable
1gtnJ-2ze3A:
undetectable		 1gtnI-2ze3A:
15.81
1gtnJ-2ze3A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 11 LEU A 125
GLY A 174
VAL A 205
LEU A 203
LEU A 129
 None
 1.04A 1mx1A-2ze3A:
undetectable		 1mx1A-2ze3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 12 VAL A 146
ALA A 150
LEU A 111
ALA A 135
ALA A 180
 None
 1.19A 1sa1C-2ze3A:
undetectable
1sa1D-2ze3A:
2.1		 1sa1C-2ze3A:
21.49
1sa1D-2ze3A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 11 TYR A  87
GLY A  65
THR A  42
ILE A  47
ARG A  66
 None
 1.43A 2f9wA-2ze3A:
undetectable
2f9wB-2ze3A:
undetectable		 2f9wA-2ze3A:
25.94
2f9wB-2ze3A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 8 ARG A  66
TYR A  87
GLY A  65
THR A  42
ILE A  47
 None
 1.31A 2f9wA-2ze3A:
undetectable
2f9wB-2ze3A:
undetectable		 2f9wA-2ze3A:
25.94
2f9wB-2ze3A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 10 ASP A  82
ILE A  47
GLY A  46
LEU A 235
ILE A  71
 AKG  A 276 (-2.9A)
None
None
None
None
 1.03A 3em4V-2ze3A:
undetectable		 3em4V-2ze3A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 8 LEU A 240
THR A 239
ALA A  23
THR A  42
ILE A  47
 None
 1.41A 3jusB-2ze3A:
undetectable		 3jusB-2ze3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 9 LEU A 240
THR A 239
ALA A  23
THR A  42
ILE A  47
 None
 1.41A 3jusB-2ze3A:
undetectable		 3jusB-2ze3A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 12 ALA A 226
PHE A 186
ASN A 208
GLY A 225
ILE A 196
 None
AKG  A 276 ( 4.8A)
None
None
None
 1.48A 3vwqA-2ze3A:
undetectable		 3vwqA-2ze3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 11 ALA A 226
PHE A 186
ASN A 208
GLY A 225
ILE A 196
 None
AKG  A 276 ( 4.8A)
None
None
None
 1.48A 3vwrA-2ze3A:
0.0		 3vwrA-2ze3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		4 / 8 ALA A 211
PRO A 213
LEU A 191
LEU A 221
 None
 0.82A 4jjkA-2ze3A:
2.1		 4jjkA-2ze3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 12 ASN A 149
GLY A  41
ASP A  82
ILE A  77
SER A 230
 None
None
AKG  A 276 (-2.9A)
None
AKG  A 276 (-2.7A)
 1.17A 4obwC-2ze3A:
undetectable		 4obwC-2ze3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 2ze3 DFA0005
(Deinococcus
ficus) 		4 / 5 ALA A 182
ALA A 150
ILE A 132
LEU A 129
 None
 0.72A 5jncD-2ze3A:
undetectable		 5jncD-2ze3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2ze3 DFA0005
(Deinococcus
ficus) 		5 / 12 ALA A  81
VAL A 109
GLY A  86
ALA A  85
TYR A 123
 None
 0.98A 5n5dA-2ze3A:
2.1		 5n5dA-2ze3A:
23.97