SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ze4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 ALA A 452
GLU A 333
ILE A 334
LEU A 460
ILE A 325
 None
 1.17A 1d1gB-2ze4A:
undetectable		 1d1gB-2ze4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 11 VAL A 448
VAL A 446
TYR A 454
LEU A   9
ILE A 471
 None
 0.95A 1t6zB-2ze4A:
2.7		 1t6zB-2ze4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		3 / 3 ALA A 213
VAL A  27
TRP A  28
 None
 0.88A 1tkqB-2ze4A:
undetectable		 1tkqB-2ze4A:
3.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 5 ASP A 355
THR A 406
LEU A 402
LEU A 405
 None
 1.22A 1u18B-2ze4A:
undetectable		 1u18B-2ze4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		6 / 11 LEU A  36
ALA A 478
ASP A 450
ILE A 471
PRO A 265
VAL A 264
 None
 1.33A 2o4pA-2ze4A:
undetectable		 2o4pA-2ze4A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		3 / 3 LEU A 205
TYR A 470
GLY A 456
 None
 0.62A 2ocuA-2ze4A:
undetectable		 2ocuA-2ze4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 10 ILE A 325
LEU A 420
ILE A 334
SER A 395
ILE A 394
 None
 1.19A 2w9sC-2ze4A:
undetectable		 2w9sC-2ze4A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		3 / 3 TYR A 216
GLU A 317
ASN A 459
 None
 0.76A 2y7hC-2ze4A:
undetectable		 2y7hC-2ze4A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLU A 317
GLU A 318
SER A 165
VAL A 274
TYR A 311
 None
 1.32A 3bjmA-2ze4A:
2.3		 3bjmA-2ze4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLU A 317
GLU A 318
SER A 165
VAL A 274
TYR A 311
 None
 1.31A 3bjmB-2ze4A:
2.7		 3bjmB-2ze4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		6 / 12 LEU A  36
ALA A 478
ASP A 450
ILE A 471
PRO A 265
VAL A 264
 None
 1.45A 3bvbB-2ze4A:
undetectable		 3bvbB-2ze4A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLN A 387
ASN A 304
LEU A 465
TYR A 461
LEU A 346
 None
 1.21A 3fsuA-2ze4A:
undetectable		 3fsuA-2ze4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLY A 214
GLY A 176
VAL A 100
ASP A  84
ILE A  85
 None
 0.96A 3gczA-2ze4A:
undetectable		 3gczA-2ze4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 4 ARG A  66
ASP A 189
GLY A 186
THR A  50
 None
 1.24A 3k4vB-2ze4A:
undetectable		 3k4vB-2ze4A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLY A 359
ASP A 355
ASN A 419
GLY A 364
ALA A 326
 None
 1.19A 3ku1G-2ze4A:
1.9		 3ku1G-2ze4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLH_A_T27A555_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 PRO A 124
LEU A 164
VAL A 274
PRO A 462
PRO A 347
 None
 1.41A 3qlhA-2ze4A:
0.5		 3qlhA-2ze4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 4 ASP A 189
ASP A 190
GLY A 186
THR A  50
 None
 1.18A 3tl9B-2ze4A:
undetectable		 3tl9B-2ze4A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 7 GLY A 359
ALA A 358
ALA A 404
ARG A 401
 None
 0.86A 3ur0B-2ze4A:
undetectable		 3ur0B-2ze4A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 9 VAL A 201
TRP A  46
LEU A  47
SER A 447
LEU A 485
 None
 1.47A 3w1wA-2ze4A:
0.0
3w1wB-2ze4A:
0.0		 3w1wA-2ze4A:
21.88
3w1wB-2ze4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLU A 317
GLU A 318
SER A 165
VAL A 274
TYR A 311
 None
 1.34A 3w2tA-2ze4A:
2.8		 3w2tA-2ze4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLU A 317
GLU A 318
SER A 165
VAL A 274
TYR A 311
 None
 1.35A 3w2tB-2ze4A:
undetectable		 3w2tB-2ze4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 PRO A 124
LEU A 164
VAL A 274
PRO A 462
PRO A 347
 None
 1.49A 4id5A-2ze4A:
undetectable		 4id5A-2ze4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 PRO A 124
LEU A 164
VAL A 274
PRO A 462
PRO A 347
 None
 1.49A 4kfbA-2ze4A:
undetectable		 4kfbA-2ze4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 6 ALA A 320
ILE A 455
GLY A 469
ILE A  12
 None
 0.81A 4r21A-2ze4A:
undetectable		 4r21A-2ze4A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 8 ARG A 352
ASP A 303
ASP A 308
ASP A 312
 None
 1.10A 4xqgA-2ze4A:
undetectable		 4xqgA-2ze4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 8 ARG A 352
ASP A 303
ASP A 308
ASP A 312
 None
 1.11A 4xqgB-2ze4A:
undetectable		 4xqgB-2ze4A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 7 ILE A  12
LEU A 321
TYR A 454
ILE A 267
 None
 0.80A 4y03A-2ze4A:
undetectable		 4y03A-2ze4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 ILE A 325
LEU A 324
GLU A 473
VAL A 367
LEU A 339
 None
 1.07A 4y0qA-2ze4A:
undetectable		 4y0qA-2ze4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 8 ALA A  79
PRO A 114
VAL A  83
ALA A 106
GLY A 103
 None
 1.38A 4zjzB-2ze4A:
undetectable		 4zjzB-2ze4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 8 TYR A 311
GLY A 273
TRP A 166
ALA A 123
 None
 0.90A 5albL-2ze4A:
undetectable		 5albL-2ze4A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 4 LEU A 422
TYR A 439
PRO A 374
ILE A 388
 None
 1.26A 5esgA-2ze4A:
undetectable		 5esgA-2ze4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 5 ALA A 213
TYR A 216
GLY A 384
LEU A 465
 None
 1.01A 5eslA-2ze4A:
undetectable		 5eslA-2ze4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 5 ALA A 307
PRO A 462
GLY A 183
LEU A 321
 None
 0.94A 5eslA-2ze4A:
undetectable		 5eslA-2ze4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 12 GLU A 317
GLU A 318
SER A 165
VAL A 274
TYR A 311
 None
 1.35A 6b1eB-2ze4A:
2.4		 6b1eB-2ze4A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 6 GLY A 207
ASN A  34
SER A 212
ARG A 211
 None
 1.23A 6dwdA-2ze4A:
undetectable
6dwdC-2ze4A:
undetectable		 6dwdA-2ze4A:
22.01
6dwdC-2ze4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		4 / 5 ILE A 184
GLN A  49
THR A  50
THR A 181
 None
 0.89A 6f3mD-2ze4A:
undetectable		 6f3mD-2ze4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ze4 PHOSPHOLIPASE D
(Streptomyces
antibioticus) 		5 / 10 TRP A  46
GLY A 207
ARG A  35
LEU A  36
LEU A 441
 None
 1.35A 6hqbA-2ze4A:
undetectable
6hqbJ-2ze4A:
undetectable		 6hqbA-2ze4A:
12.20
6hqbJ-2ze4A:
6.99