SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ze5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 2ze5 ISOPENTENYL
TRANSFERASE
(Agrobacterium
tumefaciens) 		5 / 9 PRO A 193
SER A 190
LEU A 203
LEU A 187
ASP A 186
 None
 1.46A 1lbcB-2ze5A:
undetectable		 1lbcB-2ze5A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2ze5 ISOPENTENYL
TRANSFERASE
(Agrobacterium
tumefaciens) 		5 / 12 TYR A 211
GLY A  97
GLY A   8
LEU A 152
THR A  43
 None
 0.89A 1p91B-2ze5A:
undetectable		 1p91B-2ze5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 2ze5 ISOPENTENYL
TRANSFERASE
(Agrobacterium
tumefaciens) 		4 / 8 VAL A  35
GLY A  46
HIS A 214
TYR A 211
 AMP  A 401 ( 4.3A)
None
AMP  A 401 (-4.0A)
None
 1.01A 3af0A-2ze5A:
6.9		 3af0A-2ze5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2ze5 ISOPENTENYL
TRANSFERASE
(Agrobacterium
tumefaciens) 		5 / 9 LEU A 203
ASP A 173
GLY A  44
ILE A 204
ILE A 207
 None
AMP  A 401 (-4.0A)
None
None
None
 1.10A 3s56B-2ze5A:
undetectable		 3s56B-2ze5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2ze5 ISOPENTENYL
TRANSFERASE
(Agrobacterium
tumefaciens) 		3 / 4 ARG A  87
GLY A  92
GLU A  90
 None
 0.68A 4z2dB-2ze5A:
undetectable
4z2dC-2ze5A:
undetectable		 4z2dB-2ze5A:
18.50
4z2dC-2ze5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2ze5 ISOPENTENYL
TRANSFERASE
(Agrobacterium
tumefaciens) 		4 / 8 GLU A  50
ARG A  57
THR A  56
ILE A  19
 None
 1.02A 6a4iA-2ze5A:
undetectable		 6a4iA-2ze5A:
21.45