SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
2zec TRYPTASE BETA 2
(Homo
sapiens)
7 / 8 HIS A  59
ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
None
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.50A 1aq7A-2zecA:
32.4
1aq7A-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
6 / 9 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.52A 1bcuH-2zecA:
33.7
1bcuH-2zecA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 9 HIS A  59
ASP A 203
SER A 209
TRP A 229
GLY A 240
None
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
0.43A 1dwcH-2zecA:
33.2
1dwcH-2zecA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
7 / 12 HIS A  59
ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
None
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.55A 1etrH-2zecA:
33.3
1etrH-2zecA:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
2zec TRYPTASE BETA 2
(Homo
sapiens)
7 / 8 ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.43A 1f5lA-2zecA:
34.0
1f5lA-2zecA:
35.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 8 ASP A 106
PHE A  98
SER A 209
ALA A 108
None
None
11N  A   1 (-3.3A)
None
1.05A 1rqpC-2zecA:
undetectable
1rqpC-2zecA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 8 ASP A 106
PHE A  98
SER A 209
ALA A 108
None
None
11N  A   1 (-3.3A)
None
1.04A 1rqpA-2zecA:
undetectable
1rqpA-2zecA:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
6 / 6 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.36A 1tnlA-2zecA:
32.7
1tnlA-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 GLY A  45
GLY A 211
LEU A 213
GLY A 225
LYS A  26
None
1.19A 1y4lA-2zecA:
undetectable
1y4lA-2zecA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 7 GLY A  46
GLY A 211
VAL A  73
LEU A 110
None
0.76A 2oa1B-2zecA:
undetectable
2oa1B-2zecA:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
6 / 6 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.36A 2otvA-2zecA:
32.9
2otvA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
2zec TRYPTASE BETA 2
(Homo
sapiens)
7 / 12 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
TYR A 242
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
None
0.38A 2p16A-2zecA:
32.9
2p16A-2zecA:
34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
2zec TRYPTASE BETA 2
(Homo
sapiens)
7 / 8 ASP A 203
SER A 204
GLN A 206
SER A 209
VAL A 227
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
None
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.36A 2vinA-2zecA:
34.4
2vinA-2zecA:
35.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
8 / 12 ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 232
GLY A 240
TYR A 242
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.8A)
11N  A   1 (-3.6A)
None
0.47A 2w26A-2zecA:
32.9
2w26A-2zecA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
3 / 3 GLY A 211
GLY A 207
GLY A  45
None
0.41A 3bogC-2zecA:
undetectable
3bogC-2zecA:
15.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
7 / 11 HIS A  59
ASP A 203
SER A 204
SER A 209
TRP A 229
GLY A 230
GLY A 240
None
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.33A 3gy3A-2zecA:
12.7
3gy3A-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 LEU A 110
GLY A  45
GLY A  46
SER A 204
ASP A 106
None
None
None
11N  A   1 (-3.5A)
None
1.09A 3i5uB-2zecA:
undetectable
3i5uB-2zecA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 LEU A  33
ALA A  57
TRP A 229
GLY A  46
ALA A 101
None
1.21A 3ou6C-2zecA:
undetectable
3ou6C-2zecA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 LEU A  33
ALA A  57
TRP A 229
GLY A  46
ALA A 101
None
1.24A 3ou7C-2zecA:
undetectable
3ou7C-2zecA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.92A 3pghC-2zecA:
undetectable
3pghC-2zecA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.83A 3rr3A-2zecA:
undetectable
3rr3A-2zecA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.83A 3rr3B-2zecA:
undetectable
3rr3B-2zecA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
6 / 6 SER A 204
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.41A 3rxfA-2zecA:
13.5
3rxfA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 5 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
0.35A 3rxhA-2zecA:
32.8
3rxhA-2zecA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 LEU A  71
GLY A 211
GLY A 210
LEU A 110
GLY A 146
None
1.04A 3vaqA-2zecA:
undetectable
3vaqA-2zecA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 LEU A  71
GLY A 211
GLY A 210
LEU A 110
GLY A 146
None
1.06A 3vasA-2zecA:
undetectable
3vasA-2zecA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 LEU A  71
GLY A 211
GLY A 210
LEU A 110
GLY A 146
None
1.05A 3vasB-2zecA:
undetectable
3vasB-2zecA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
3 / 3 TRP A 141
TRP A  27
THR A 143
None
1.49A 4bboB-2zecA:
undetectable
4bboB-2zecA:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 5 HIS A  59
GLN A 206
GLY A 207
SER A 209
None
None
None
11N  A   1 (-3.3A)
0.32A 4fu8A-2zecA:
34.2
4fu8A-2zecA:
35.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 HIS A  59
ASP A 203
VAL A 227
TRP A 229
GLY A 240
None
11N  A   1 (-2.6A)
None
None
11N  A   1 (-3.6A)
0.37A 4hfpD-2zecA:
33.1
4hfpD-2zecA:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 VAL A 245
GLY A  46
ILE A 107
LEU A 109
LEU A  48
None
1.03A 4qdjA-2zecA:
undetectable
4qdjA-2zecA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 HIS A  59
VAL A 227
TRP A 229
GLY A 230
GLY A 240
None
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.48A 4rn6B-2zecA:
28.0
4rn6B-2zecA:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 5 PHE A  98
PRO A  96
VAL A  94
ALA A 105
None
0.89A 4w5oA-2zecA:
undetectable
4w5oA-2zecA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 5 PHE A  98
PRO A  96
VAL A  94
ALA A 105
None
0.90A 4z4cA-2zecA:
undetectable
4z4cA-2zecA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 5 PHE A  98
PRO A  96
VAL A  94
ALA A 105
None
0.91A 4z4dA-2zecA:
undetectable
4z4dA-2zecA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 5 PHE A  98
PRO A  96
VAL A  94
ALA A 105
None
0.90A 4z4eA-2zecA:
undetectable
4z4eA-2zecA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
3 / 3 THR A 124
HIS A 254
LEU A 109
None
0.79A 5axdA-2zecA:
undetectable
5axdA-2zecA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
3 / 3 THR A 124
HIS A 254
LEU A 109
None
0.80A 5axdC-2zecA:
undetectable
5axdC-2zecA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
6 / 12 GLY A 146
GLY A  46
GLY A 210
GLY A 207
THR A  56
VAL A  54
None
1.26A 5eiwC-2zecA:
undetectable
5eiwC-2zecA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 VAL A  61
VAL A  54
VAL A 226
GLY A 211
LEU A  33
None
0.90A 5iktA-2zecA:
undetectable
5iktA-2zecA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
2zec TRYPTASE BETA 2
(Homo
sapiens)
4 / 6 PHE A  98
PRO A  96
VAL A  94
ALA A 105
None
0.91A 5t7bA-2zecA:
undetectable
5t7bA-2zecA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 GLY A 146
GLY A 210
GLY A  45
GLY A 144
PHE A  98
None
0.92A 5vimA-2zecA:
undetectable
5vimA-2zecA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)
2zec TRYPTASE BETA 2
(Homo
sapiens)
5 / 12 GLY A 146
GLY A 210
GLY A  45
GLY A 144
PHE A  98
None
0.93A 5vimB-2zecA:
undetectable
5vimB-2zecA:
19.06