SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zet'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		5 / 12 THR A  41
GLY A  21
GLY A  19
GLY A  77
ASP A 136
 GTP  A 203 ( 3.4A)
GTP  A 203 (-3.0A)
GTP  A 203 (-3.3A)
GTP  A 203 (-3.3A)
GTP  A 203 (-2.7A)
 1.04A 2b25A-2zetA:
undetectable		 2b25A-2zetA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		5 / 12 ALA A  14
LEU A  15
LEU A  13
ILE A  10
LEU A 177
 None
 1.11A 2jfaA-2zetA:
undetectable		 2jfaA-2zetA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 2zet MELANOPHILIN
RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		4 / 6 ASP A   7
ARG C  35
ILE C 115
ARG C 111
 None
 1.40A 3ckzA-2zetA:
undetectable		 3ckzA-2zetA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		5 / 12 LEU A  96
LEU A  12
ALA A  92
LEU A 117
THR A  85
 None
 1.34A 3gwuA-2zetA:
undetectable		 3gwuA-2zetA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2zet MELANOPHILIN
RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		6 / 11 VAL C 137
VAL C  18
GLY A  43
ALA A  76
LEU C 141
LEU C   5
 None
 1.45A 3sm2B-2zetC:
undetectable		 3sm2B-2zetC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		4 / 5 LEU A  12
LEU A 177
ILE A 181
ARG A 184
 None
 0.88A 4klrA-2zetA:
4.5		 4klrA-2zetA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2zet MELANOPHILIN
(Mus
musculus) 		4 / 4 LEU C  59
SER C  54
LEU C  86
LEU C  68
 None
 1.10A 4n09A-2zetC:
undetectable		 4n09A-2zetC:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 2zet MELANOPHILIN
(Mus
musculus) 		4 / 5 LEU C  59
SER C  54
LEU C  86
LEU C  68
 None
 1.11A 4n09B-2zetC:
undetectable		 4n09B-2zetC:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zet MELANOPHILIN
RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		4 / 5 ILE C 115
ASP A 127
GLU A 186
VAL A  68
 None
 1.24A 4nkxC-2zetC:
undetectable		 4nkxC-2zetC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zet MELANOPHILIN
RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		4 / 5 ILE C 115
ASP A 127
GLU A 186
VAL A  68
 None
 1.27A 4nkxD-2zetC:
undetectable		 4nkxD-2zetC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		3 / 3 PHE A  25
ILE A 131
ASP A  17
 None
 0.69A 5cswA-2zetA:
undetectable		 5cswA-2zetA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		3 / 3 PHE A  25
ILE A 131
ASP A  17
 None
 0.75A 5cswB-2zetA:
undetectable		 5cswB-2zetA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		4 / 7 LEU A  97
ILE A  44
THR A  85
TRP A  73
 None
 1.45A 5ljcA-2zetA:
undetectable		 5ljcA-2zetA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		5 / 10 VAL A  51
LEU A  70
LEU A  72
LEU A 177
LEU A 178
 None
 0.74A 6f6nA-2zetA:
undetectable
6f6nB-2zetA:
undetectable		 6f6nA-2zetA:
17.92
6f6nB-2zetA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2zet RAS-RELATED PROTEIN
RAB-27B
(Mus
musculus) 		4 / 6 VAL A  51
LEU A  70
LEU A  72
LEU A 177
 None
 0.66A 6f6sA-2zetA:
undetectable
6f6sB-2zetA:
undetectable		 6f6sA-2zetA:
17.92
6f6sB-2zetA:
13.88