SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LH6_A_NIOA155_1 (LEGHEMOGLOBIN A (NICOTINATE MET))	2zfb	HEMOGLOBIN SUBUNIT ALPHA (Psittacula krameri)	4 / 7	PHE A 43 PHE A 46 VAL A 62 HIS A 87	HEM A 150 (-3.6A) HEM A 150 (-4.6A) HEM A 150 ( 3.9A) HEM A 150 (-3.3A)	0.91A	1lh6A-2zfbA: 12.8	1lh6A-2zfbA: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SMT_A_ACTA500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD3)	2zfb	HEMOGLOBIN SUBUNIT ALPHA (Psittacula krameri)	3 / 3	PHE A 46 SER A 52 GLN A 54	HEM A 150 (-4.6A) None None	0.76A	3smtA-2zfbA: 1.4	3smtA-2zfbA: 16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUD_D_ERMD1201_1 (5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA)	2zfb	HEMOGLOBIN SUBUNIT ALPHA (Psittacula krameri)	5 / 12	VAL A 62 PHE A 128 VAL A 109 LEU A 129 VAL A 132	HEM A 150 ( 3.9A) None None None None	1.23A	5tudD-2zfbA: undetectable	5tudD-2zfbA: 15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUI_B_CTCB405_0 (TETRACYCLINE DESTRUCTASE TET(50))	2zfb	HEMOGLOBIN SUBUNIT ALPHA (Psittacula krameri)	5 / 12	GLY A 133 PHE A 98 LEU A 83 GLY A 64 GLY A 102	None HEM A 150 (-4.2A) HEM A 150 (-4.6A) None None	1.10A	5tuiB-2zfbA: undetectable	5tuiB-2zfbA: 14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_H_PCFH604_0 (CYTOCHROME B-C1 COMPLEX SUBUNIT 8 CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL)	2zfb	HEMOGLOBIN SUBUNIT ALPHA (Psittacula krameri)	4 / 8	GLY A 19 GLY A 64 SER A 67 ALA A 70	None	0.69A	6hu9H-2zfbA: undetectable 6hu9e-2zfbA: undetectable	6hu9H-2zfbA: 20.14 6hu9e-2zfbA: 18.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LH6_A_NIOA155_1","LEGHEMOGLOBIN A (NICOTINATE MET)","2zfb","HEMOGLOBIN SUBUNIT ALPHA","Psittacula krameri",4,"PHE A  43;PHE A  46;VAL A  62;HIS A  87","HEM A 150 (-3.6A);HEM A 150 (-4.6A);HEM A 150 ( 3.9A);HEM A 150 (-3.3A)","0.91A","1lh6A-2zfbA:12.8","1lh6A-2zfbA:22.15"],["3SMT_A_ACTA500_0","HISTONE-LYSINE N-METHYLTRANSFERASE SETD3","2zfb","HEMOGLOBIN SUBUNIT ALPHA","Psittacula krameri",3,"PHE A  46;SER A  52;GLN A  54","HEM A 150 (-4.6A);None;None","0.76A","3smtA-2zfbA:1.4","3smtA-2zfbA:16.53"],["5TUD_D_ERMD1201_1","5-HYDROXYTRYPTAMINE RECEPTOR 2B,SOLUBLE CYTOCHROME B562 CHIMERA","2zfb","HEMOGLOBIN SUBUNIT ALPHA","Psittacula krameri",5,"VAL A  62;PHE A 128;VAL A 109;LEU A 129;VAL A 132","HEM A 150 ( 3.9A);None;None;None;None","1.23A","5tudD-2zfbA:undetectable","5tudD-2zfbA:15.05"],["5TUI_B_CTCB405_0","TETRACYCLINE DESTRUCTASE TET(50)","2zfb","HEMOGLOBIN SUBUNIT ALPHA","Psittacula krameri",5,"GLY A 133;PHE A  98;LEU A  83;GLY A  64;GLY A 102","None;HEM A 150 (-4.2A);HEM A 150 (-4.6A);None;None","1.10A","5tuiB-2zfbA:undetectable","5tuiB-2zfbA:14.63"],["6HU9_H_PCFH604_0","CYTOCHROME B-C1 COMPLEX SUBUNIT 8;CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL","2zfb","HEMOGLOBIN SUBUNIT ALPHA","Psittacula krameri",4,"GLY A  19;GLY A  64;SER A  67;ALA A  70","None","0.69A","6hu9H-2zfbA:undetectable;6hu9e-2zfbA:undetectable","6hu9H-2zfbA:20.14;6hu9e-2zfbA:18.71"]]