SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zfd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		5 / 12 ASP A 166
GLU A 165
ASP A 161
ARG A 141
ILE B 315
 None
 1.16A 1s14A-2zfdA:
undetectable		 1s14A-2zfdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		4 / 7 LEU A 111
PHE A  94
LEU B 327
PHE A 126
 None
 1.05A 1wrlE-2zfdA:
10.1
1wrlF-2zfdA:
10.1		 1wrlE-2zfdA:
20.00
1wrlF-2zfdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		5 / 11 ILE B 316
ALA B 312
THR A 171
ARG A 189
LEU A 191
 None
 1.31A 2v0mD-2zfdB:
undetectable		 2v0mD-2zfdB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2zfd PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		5 / 12 LEU B 362
ILE B 374
MET B 372
LEU B 353
ARG B 348
 None
None
None
None
ACY  B   2 (-4.2A)
 1.18A 3gyqA-2zfdB:
undetectable
3gyqB-2zfdB:
undetectable		 3gyqA-2zfdB:
18.94
3gyqB-2zfdB:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		5 / 12 ASP A 166
GLU A 165
ASP A 161
ARG A 141
ILE B 315
 None
 1.15A 3lpsA-2zfdA:
undetectable		 3lpsA-2zfdA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		4 / 5 SER A 127
GLY B 318
GLU B 386
GLU B 398
 None
 1.37A 3raeB-2zfdA:
undetectable
3raeD-2zfdA:
undetectable		 3raeB-2zfdA:
19.76
3raeD-2zfdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
(Arabidopsis
thaliana) 		4 / 5 LEU A 198
LEU A 199
LEU A 193
SER A 190
 None
 0.91A 3vhuA-2zfdA:
undetectable		 3vhuA-2zfdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		3 / 3 TYR A 206
ARG B 332
SER B 325
 None
 1.06A 4khpI-2zfdA:
undetectable
4khpJ-2zfdA:
undetectable		 4khpI-2zfdA:
22.97
4khpJ-2zfdA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		5 / 12 PHE A  42
LEU A 207
PHE B 328
GLY A 103
PHE A  94
 None
 1.20A 4kykA-2zfdA:
undetectable
4kykB-2zfdA:
undetectable		 4kykA-2zfdA:
21.52
4kykB-2zfdA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2zfd CALCINEURIN B-LIKE
PROTEIN 2
PUTATIVE
UNCHARACTERIZED
PROTEIN T20L15_90
(Arabidopsis
thaliana) 		5 / 11 ASP A 166
GLU A 165
ASP A 161
ARG A 141
ILE B 315
 None
 1.14A 4urnB-2zfdA:
undetectable		 4urnB-2zfdA:
23.39