SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 5 VAL A 342
CYH A 332
ALA A 323
CYH A 320
None
1.12A 1mz9D-2zfuA:
undetectable
1mz9D-2zfuA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 GLY A 316
GLY A 318
LEU A 335
ASP A 346
CYH A 363
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.4A)
0.93A 1x1aA-2zfuA:
12.9
1x1aA-2zfuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
3 / 3 ARG A 298
VAL A 415
GLY A 386
None
0.66A 2avvE-2zfuA:
undetectable
2avvE-2zfuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 11 SER A 263
GLY A 261
SER A 260
LEU A 366
ASP A 346
SAH  A 900 (-4.2A)
None
None
None
SAH  A 900 (-3.6A)
0.99A 2c2bE-2zfuA:
0.7
2c2bF-2zfuA:
0.5
2c2bE-2zfuA:
18.84
2c2bF-2zfuA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 5 PHE A 374
PHE A 362
LEU A 388
PHE A 412
SAH  A 900 (-4.3A)
None
None
None
1.36A 2y69C-2zfuA:
undetectable
2y69J-2zfuA:
undetectable
2y69C-2zfuA:
19.85
2y69J-2zfuA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 5 PHE A 374
PHE A 362
LEU A 388
PHE A 412
SAH  A 900 (-4.3A)
None
None
None
1.36A 3abmP-2zfuA:
undetectable
3abmW-2zfuA:
undetectable
3abmP-2zfuA:
19.85
3abmW-2zfuA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 5 PHE A 374
PHE A 362
LEU A 388
PHE A 412
SAH  A 900 (-4.3A)
None
None
None
1.33A 3ag3C-2zfuA:
undetectable
3ag3J-2zfuA:
undetectable
3ag3C-2zfuA:
19.85
3ag3J-2zfuA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 GLY A 318
LEU A 322
LEU A 335
ASP A 346
MET A 347
SAH  A 900 ( 3.7A)
None
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.75A 3g2oB-2zfuA:
12.4
3g2oB-2zfuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 GLY A 318
LEU A 335
ASP A 346
MET A 347
SER A 365
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
SAH  A 900 (-4.7A)
0.95A 3g2oB-2zfuA:
12.4
3g2oB-2zfuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
3 / 3 ASP A 334
PHE A 270
SER A 263
SAH  A 900 (-2.7A)
None
SAH  A 900 (-4.2A)
0.79A 3i5uB-2zfuA:
11.6
3i5uB-2zfuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
3 / 3 GLY A 318
ASP A 334
ASP A 346
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
SAH  A 900 (-3.6A)
0.36A 3ou7C-2zfuA:
10.2
3ou7C-2zfuA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 TYR A 280
GLY A 318
LEU A 335
ASP A 346
MET A 347
None
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.98A 3pfgA-2zfuA:
11.6
3pfgA-2zfuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 7 ILE A 326
LEU A 322
VAL A 381
SER A 356
None
0.97A 3r9vA-2zfuA:
undetectable
3r9vB-2zfuA:
undetectable
3r9vA-2zfuA:
22.66
3r9vB-2zfuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 6 LEU A 352
VAL A 350
PHE A 315
VAL A 357
None
1.12A 3soaA-2zfuA:
undetectable
3soaA-2zfuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 LEU A 375
PHE A 403
VAL A 407
PHE A 397
GLN A 449
None
1.32A 4c9wA-2zfuA:
undetectable
4c9wA-2zfuA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 11 PHE A 284
ASP A 314
GLY A 316
GLY A 318
ASP A 334
SAH  A 900 (-3.7A)
SAH  A 900 ( 4.6A)
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
0.68A 4dcmA-2zfuA:
12.1
4dcmA-2zfuA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 GLY A 316
GLY A 318
LEU A 335
MET A 347
SER A 365
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-4.7A)
0.46A 4f84A-2zfuA:
12.7
4f84A-2zfuA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 TYR A 280
GLY A 316
GLY A 318
LEU A 335
ASP A 346
None
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
0.91A 4krhA-2zfuA:
11.1
4krhA-2zfuA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 11 GLY A 316
ASP A 334
LEU A 335
ASP A 346
MET A 347
SAH  A 900 (-3.5A)
SAH  A 900 (-2.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.52A 4pghA-2zfuA:
7.5
4pghA-2zfuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 11 GLY A 318
ASP A 334
LEU A 335
ASP A 346
MET A 347
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.92A 4pghA-2zfuA:
7.5
4pghA-2zfuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
6 / 12 ASP A 314
GLY A 316
ASP A 334
LEU A 335
ASP A 346
MET A 347
SAH  A 900 ( 4.6A)
SAH  A 900 (-3.5A)
SAH  A 900 (-2.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.65A 4pghB-2zfuA:
10.5
4pghB-2zfuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 11 GLY A 316
ASP A 334
LEU A 335
ASP A 346
MET A 347
SAH  A 900 (-3.5A)
SAH  A 900 (-2.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.58A 4pghC-2zfuA:
11.2
4pghC-2zfuA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
3 / 3 MET A 367
ASP A 334
PHE A 333
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
None
0.72A 4xeyA-2zfuA:
undetectable
4xeyA-2zfuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
3 / 3 MET A 367
ASP A 334
PHE A 333
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
None
0.69A 4xeyB-2zfuA:
1.1
4xeyB-2zfuA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 SER A 286
TRP A 291
LEU A 364
TYR A 280
ASN A 255
None
None
SAH  A 900 (-4.9A)
None
None
1.35A 5dsgB-2zfuA:
undetectable
5dsgB-2zfuA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 4 ASP A 314
GLY A 318
ASP A 334
ASP A 346
SAH  A 900 ( 4.6A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
SAH  A 900 (-3.6A)
0.53A 5e72A-2zfuA:
10.9
5e72A-2zfuA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 7 VAL A 390
LEU A 388
LEU A 366
LEU A 448
None
0.69A 5jq7A-2zfuA:
undetectable
5jq7A-2zfuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 11 LEU A 388
GLU A 355
GLY A 385
LEU A 375
ALA A 378
None
1.07A 5o96A-2zfuA:
undetectable
5o96B-2zfuA:
undetectable
5o96A-2zfuA:
24.00
5o96B-2zfuA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
3 / 3 ARG A 298
PHE A 362
LEU A 322
None
0.70A 5veuA-2zfuA:
undetectable
5veuA-2zfuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 5 PHE A 374
PHE A 362
LEU A 388
PHE A 412
SAH  A 900 (-4.3A)
None
None
None
1.34A 5wauC-2zfuA:
undetectable
5wauJ-2zfuA:
undetectable
5wauC-2zfuA:
19.85
5wauJ-2zfuA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
4 / 5 PHE A 374
PHE A 362
LEU A 388
PHE A 412
SAH  A 900 (-4.3A)
None
None
None
1.34A 5xdqC-2zfuA:
undetectable
5xdqJ-2zfuA:
undetectable
5xdqC-2zfuA:
19.85
5xdqJ-2zfuA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
6 / 11 GLY A 316
GLY A 318
ASP A 334
LEU A 335
ASP A 346
MET A 347
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
SAH  A 900 (-2.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
0.50A 6i5zD-2zfuA:
10.1
6i5zD-2zfuA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)
5 / 12 ASP A 314
GLY A 316
GLY A 318
ALA A 336
ASP A 346
SAH  A 900 ( 4.6A)
SAH  A 900 (-3.5A)
SAH  A 900 ( 3.7A)
None
SAH  A 900 (-3.6A)
1.05A 6nj9K-2zfuA:
3.1
6nj9K-2zfuA:
20.05