SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 10 ASP A 181
GLY A 183
GLY A  27
LEU A 186
ALA A 214
 None
 1.11A 1x7pA-2zghA:
undetectable
1x7pB-2zghA:
undetectable		 1x7pA-2zghA:
23.00
1x7pB-2zghA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 11 HIS A  74
PRO A  75
TRP A 223
LYS A 226
VAL A 227
 None
 0.61A 2h9tH-2zghA:
32.2		 2h9tH-2zghA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2zgh GRANZYME M
(Homo
sapiens) 		6 / 12 GLY A 126
GLY A  28
GLY A 183
GLY A 180
THR A  38
LEU A  37
 None
 1.44A 2oxtD-2zghA:
undetectable		 2oxtD-2zghA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 11 HIS A  41
LEU A 186
GLY A 184
VAL A  29
ALA A 214
 None
 1.09A 2yy8A-2zghA:
undetectable
2yy8B-2zghA:
undetectable		 2yy8A-2zghA:
21.32
2yy8B-2zghA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 11 HIS A  74
PRO A  75
TRP A 223
LYS A 226
VAL A 227
 None
 0.64A 3bf6H-2zghA:
32.1		 3bf6H-2zghA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zgh GRANZYME M
(Homo
sapiens) 		3 / 3 GLY A 184
GLY A 180
GLY A  27
 None
 0.36A 3bogC-2zghA:
undetectable		 3bogC-2zghA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2zgh GRANZYME M
(Homo
sapiens) 		4 / 7 LEU A 107
GLN A  91
LEU A  54
VAL A  29
 None
 0.74A 3g8iA-2zghA:
undetectable		 3g8iA-2zghA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 9 VAL A  31
ILE A 224
ALA A  88
VAL A 197
VAL A 217
 None
 0.89A 3me6C-2zghA:
undetectable		 3me6C-2zghA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 9 VAL A  31
ILE A 224
ALA A  88
VAL A 197
VAL A 217
 None
 0.90A 3me6D-2zghA:
undetectable		 3me6D-2zghA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2zgh GRANZYME M
(Homo
sapiens) 		5 / 12 MET A  15
ASP A 181
ILE A   2
SER A 121
ARG A 192
 None
 1.46A 4djfB-2zghA:
undetectable		 4djfB-2zghA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zgh GRANZYME M
(Homo
sapiens) 		4 / 5 GLY A  27
LEU A 194
LEU A  87
LEU A  92
 None
 0.81A 4o8fA-2zghA:
undetectable		 4o8fA-2zghA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zgh GRANZYME M
(Homo
sapiens) 		3 / 3 THR A 215
HIS A  32
LEU A 107
 None
 0.74A 5axdA-2zghA:
undetectable		 5axdA-2zghA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zgh GRANZYME M
(Homo
sapiens) 		3 / 3 THR A 215
HIS A  32
LEU A 107
 None
 0.75A 5axdC-2zghA:
undetectable		 5axdC-2zghA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2zgh GRANZYME M
(Homo
sapiens) 		4 / 6 SER A  61
GLY A 126
ARG A 139
GLY A 124
 None
None
SO4  A 241 (-3.9A)
None
 0.92A 5cdnC-2zghA:
undetectable
5cdnD-2zghA:
undetectable		 5cdnC-2zghA:
17.49
5cdnD-2zghA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2zgh GRANZYME M
(Homo
sapiens) 		4 / 6 SER A  61
GLY A 126
ARG A 139
GLY A 124
 None
None
SO4  A 241 (-3.9A)
None
 0.94A 5cdnT-2zghA:
undetectable
5cdnU-2zghA:
undetectable		 5cdnT-2zghA:
17.49
5cdnU-2zghA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 2zgh GRANZYME M
(Homo
sapiens) 		4 / 6 HIS A  41
LEU A 198
PRO A 177
SER A 201
 None
 1.32A 5syjA-2zghA:
undetectable		 5syjA-2zghA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 2zgh GRANZYME M
(Homo
sapiens) 		4 / 6 HIS A  41
LEU A 198
PRO A 177
SER A 201
 None
 1.32A 5syjB-2zghA:
undetectable		 5syjB-2zghA:
16.57