SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zgi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		5 / 12 ALA A  76
GLY A  32
GLY A  33
LEU A  79
LEU A  70
 None
 0.97A 1ya4A-2zgiA:
undetectable		 1ya4A-2zgiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		4 / 5 LEU A 100
PRO A 101
LEU A 104
ARG A 110
 None
 0.79A 2qd4A-2zgiA:
undetectable		 2qd4A-2zgiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		3 / 3 ASP A  59
PHE A  62
LEU A  66
 None
 0.66A 2zi9A-2zgiA:
undetectable		 2zi9A-2zgiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		4 / 4 LEU A 100
PRO A 101
LEU A 104
ARG A 110
 None
 0.90A 3hcoA-2zgiA:
undetectable		 3hcoA-2zgiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		5 / 12 GLY A 160
VAL A 111
ALA A 136
LEU A 180
LEU A 150
 None
None
None
PLP  A 248 (-4.4A)
None
 1.05A 3p2kC-2zgiA:
undetectable		 3p2kC-2zgiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		4 / 4 LEU A 149
GLY A 148
GLY A 160
THR A 163
 None
 0.81A 3si7A-2zgiA:
undetectable		 3si7A-2zgiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		4 / 5 LEU A 149
GLY A 148
GLY A 160
THR A 163
 None
 0.81A 3si7C-2zgiA:
undetectable
3si7D-2zgiA:
undetectable		 3si7C-2zgiA:
21.60
3si7D-2zgiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		3 / 3 SER A 161
TYR A 130
PRO A 165
 None
 0.96A 4kanA-2zgiA:
undetectable		 4kanA-2zgiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		3 / 3 LEU A 100
PRO A 101
ARG A 110
 None
 0.65A 4klrB-2zgiA:
undetectable		 4klrB-2zgiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		5 / 10 PRO A  35
ALA A  94
GLU A  67
PHE A  83
LEU A  42
 None
 1.31A 4la0A-2zgiA:
undetectable		 4la0A-2zgiA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		3 / 3 SER A 161
TYR A 130
PRO A 165
 None
 0.95A 4lbgA-2zgiA:
undetectable		 4lbgA-2zgiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		3 / 3 SER A 161
TYR A 130
PRO A 165
 None
 0.95A 4lbgB-2zgiA:
undetectable		 4lbgB-2zgiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		4 / 5 GLY A 217
ARG A 162
GLU A 147
PHE A 146
 PLP  A 248 (-3.5A)
None
None
None
 1.29A 4r82A-2zgiA:
undetectable
4r82B-2zgiA:
undetectable		 4r82A-2zgiA:
21.83
4r82B-2zgiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2zgi PUTATIVE
4-AMINO-4-DEOXYCHORI
SMATE LYASE
(Thermus
thermophilus) 		3 / 3 ARG A 112
ARG A 110
ARG A 141
 None
 0.69A 5vcgA-2zgiA:
undetectable		 5vcgA-2zgiA:
20.33