SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.89A 1v55N-2zgkA:
undetectable
1v55W-2zgkA:
undetectable		 1v55N-2zgkA:
15.56
1v55W-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 PHE A  93
ARG A  63
THR A  46
LEU A  47
 None
 1.02A 2eikA-2zgkA:
undetectable
2eikJ-2zgkA:
undetectable		 2eikA-2zgkA:
15.56
2eikJ-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.81A 2einA-2zgkA:
undetectable
2einJ-2zgkA:
undetectable		 2einA-2zgkA:
15.56
2einJ-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 6 ILE A 115
ARG A  63
THR A  46
LEU A  47
 None
 1.01A 2einN-2zgkA:
undetectable
2einW-2zgkA:
undetectable		 2einN-2zgkA:
15.56
2einW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		5 / 12 THR A  12
ASN A  48
THR A  45
ALA A 151
VAL A  20
 None
 1.11A 2nniA-2zgkA:
undetectable		 2nniA-2zgkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 6 ARG A  85
ASN A  43
ASN A 116
LEU A  33
 None
 1.08A 2nyrA-2zgkA:
undetectable		 2nyrA-2zgkA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.90A 3abkA-2zgkA:
undetectable
3abkJ-2zgkA:
undetectable		 3abkA-2zgkA:
15.56
3abkJ-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.91A 3abmN-2zgkA:
undetectable
3abmW-2zgkA:
undetectable		 3abmN-2zgkA:
15.56
3abmW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.88A 3ag3N-2zgkA:
undetectable
3ag3W-2zgkA:
undetectable		 3ag3N-2zgkA:
15.56
3ag3W-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.92A 3asoN-2zgkA:
undetectable
3asoW-2zgkA:
undetectable		 3asoN-2zgkA:
15.56
3asoW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 6 ASN A  43
ARG A  63
TRP A  80
GLU A  83
 None
 1.13A 3galA-2zgkA:
16.3		 3galA-2zgkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		5 / 6 HIS A  59
ARG A  63
ASN A  72
TRP A  80
GLU A  83
 None
 0.63A 3galA-2zgkA:
16.3		 3galA-2zgkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		5 / 6 HIS A  59
ARG A  63
ASN A  72
TRP A  80
GLU A  83
 None
 0.66A 3galB-2zgkA:
15.8		 3galB-2zgkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 6 VAL A 120
PHE A  71
VAL A 104
PHE A  62
 None
 1.07A 3soaA-2zgkA:
undetectable		 3soaA-2zgkA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 VAL A 149
ILE A   8
LEU A  58
LEU A  49
 None
 1.00A 4l1wA-2zgkA:
undetectable		 4l1wA-2zgkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 VAL A 149
ILE A   8
LEU A  58
LEU A  49
 None
 0.97A 4xo7A-2zgkA:
undetectable		 4xo7A-2zgkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 ILE A  60
PHE A  71
VAL A 102
ILE A 115
 None
 0.80A 4zzbC-2zgkA:
undetectable
4zzbD-2zgkA:
undetectable		 4zzbC-2zgkA:
20.13
4zzbD-2zgkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.92A 5b1bN-2zgkA:
undetectable
5b1bW-2zgkA:
undetectable		 5b1bN-2zgkA:
15.56
5b1bW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.92A 5b3sN-2zgkA:
undetectable
5b3sW-2zgkA:
undetectable		 5b3sN-2zgkA:
15.56
5b3sW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 7 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.91A 5iy5N-2zgkA:
undetectable
5iy5W-2zgkA:
undetectable		 5iy5N-2zgkA:
15.56
5iy5W-2zgkA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 8 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.91A 5zcpN-2zgkA:
undetectable
5zcpW-2zgkA:
undetectable		 5zcpN-2zgkA:
15.56
5zcpW-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		5 / 7 ASN A  43
ARG A  63
TRP A  80
GLU A  83
ARG A  85
 None
 1.05A 6b8kA-2zgkA:
16.1		 6b8kA-2zgkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		6 / 7 HIS A  59
ARG A  63
ASN A  72
TRP A  80
GLU A  83
ARG A  85
 None
 0.56A 6b8kA-2zgkA:
16.1		 6b8kA-2zgkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		6 / 8 HIS A  59
ARG A  63
ASN A  72
TRP A  80
GLU A  83
ARG A  85
 None
 0.74A 6b94A-2zgkA:
15.0		 6b94A-2zgkA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		6 / 10 HIS A  59
ARG A  63
ASN A  72
TRP A  80
GLU A  83
ARG A  85
 None
 0.77A 6b94A-2zgkA:
15.0
6b94B-2zgkA:
14.4		 6b94A-2zgkA:
19.75
6b94B-2zgkA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 4 ARG A  63
GLU A  66
GLU A  83
ARG A  85
 None
 0.70A 6fk2A-2zgkA:
16.1		 6fk2A-2zgkA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2zgk ANTI-TUMOR LECTIN
(Agrocybe
aegerita) 		4 / 4 ARG A  85
GLU A  83
GLU A  66
ARG A  63
 None
 1.00A 6fk2A-2zgkA:
16.1		 6fk2A-2zgkA:
26.35