SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2zhl GALECTIN-9
(Homo
sapiens) 		5 / 11 LEU A 101
ALA A   8
VAL A  47
TYR A 144
LEU A 142
 None
 1.49A 1kt6A-2zhlA:
undetectable		 1kt6A-2zhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2zhl GALECTIN-9
(Homo
sapiens) 		5 / 11 LEU A 101
ALA A   8
VAL A  47
TYR A 144
LEU A 142
 None
 1.45A 1kt7A-2zhlA:
undetectable		 1kt7A-2zhlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2zhl GALECTIN-9
(Homo
sapiens) 		5 / 11 TYR A  10
GLY A  19
GLN A   7
ILE A 145
PHE A 147
 None
 1.45A 2dr2A-2zhlA:
undetectable		 2dr2A-2zhlA:
16.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 6 HIS A  61
ASN A  63
ARG A  44
TRP A  82
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1491 (-4.6A)
GAL  A1493 (-3.7A)
 1.10A 3galA-2zhlA:
23.0		 3galA-2zhlA:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2zhl GALECTIN-9
(Homo
sapiens) 		6 / 6 HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
 0.32A 3galA-2zhlA:
23.0		 3galA-2zhlA:
38.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2zhl GALECTIN-9
(Homo
sapiens) 		6 / 6 HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
 0.34A 3galB-2zhlA:
23.0		 3galB-2zhlA:
38.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2zhl GALECTIN-9
(Homo
sapiens) 		5 / 11 LEU A 101
ILE A 134
VAL A  47
PHE A  45
VAL A  15
 None
 1.09A 3w67A-2zhlA:
undetectable		 3w67A-2zhlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2zhl GALECTIN-9
(Homo
sapiens) 		5 / 12 LEU A 101
ILE A 134
VAL A  47
PHE A  45
VAL A  15
 None
 1.13A 3w68A-2zhlA:
undetectable		 3w68A-2zhlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 4 ASN A  63
SER A 139
ALA A  46
VAL A  47
 GAL  A1493 (-3.6A)
None
NAG  A1491 ( 3.9A)
None
 1.03A 4x1kC-2zhlA:
undetectable		 4x1kC-2zhlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2zhl GALECTIN-9
(Homo
sapiens) 		3 / 3 ASP A 100
SER A 146
TYR A 144
 None
 0.76A 5glmA-2zhlA:
undetectable		 5glmA-2zhlA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 6 SER A  54
GLY A  80
ASN A  79
ILE A  58
 None
 1.14A 5j4nA-2zhlA:
undetectable		 5j4nA-2zhlA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 4 ASN A  63
SER A 139
ALA A  46
VAL A  47
 GAL  A1493 (-3.6A)
None
NAG  A1491 ( 3.9A)
None
 0.93A 5nm5A-2zhlA:
undetectable		 5nm5A-2zhlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 6 PHE A  45
LEU A  38
ARG A  44
GLY A  42
 None
None
NAG  A1491 (-4.6A)
None
 0.75A 5o4yA-2zhlA:
undetectable		 5o4yA-2zhlA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 6 PHE A  45
LEU A  38
ARG A  44
GLY A  42
 None
None
NAG  A1491 (-4.6A)
None
 0.66A 5o4yF-2zhlA:
undetectable		 5o4yF-2zhlA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 7 HIS A  61
ASN A  63
ARG A  44
TRP A  82
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1491 (-4.6A)
GAL  A1493 (-3.7A)
 1.10A 6b8kA-2zhlA:
23.7		 6b8kA-2zhlA:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2zhl GALECTIN-9
(Homo
sapiens) 		7 / 7 HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
ARG A  87
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
NAG  A1494 (-4.0A)
 0.39A 6b8kA-2zhlA:
23.7		 6b8kA-2zhlA:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 2zhl GALECTIN-9
(Homo
sapiens) 		4 / 8 HIS A  61
ASN A  63
ARG A  44
TRP A  82
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1491 (-4.6A)
GAL  A1493 (-3.7A)
 1.07A 6b94A-2zhlA:
19.9		 6b94A-2zhlA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 2zhl GALECTIN-9
(Homo
sapiens) 		7 / 8 HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
ARG A  87
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
NAG  A1494 (-4.0A)
 0.41A 6b94A-2zhlA:
19.9		 6b94A-2zhlA:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_B_W9TB201_0
(GALECTIN-1)		 2zhl GALECTIN-9
(Homo
sapiens) 		7 / 10 HIS A  61
ASN A  63
ARG A  65
ASN A  75
TRP A  82
GLU A  85
ARG A  87
 GAL  A1493 ( 3.9A)
GAL  A1493 (-3.6A)
NAG  A1494 ( 2.8A)
GAL  A1493 (-3.9A)
GAL  A1493 (-3.7A)
NAG  A1494 ( 2.7A)
NAG  A1494 (-4.0A)
 0.43A 6b94A-2zhlA:
19.9
6b94B-2zhlA:
19.7		 6b94A-2zhlA:
32.29
6b94B-2zhlA:
32.29