SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_1
(ALCOHOL
DEHYDROGENASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 4 GLU A  67
MET A 143
LEU A   6
SER A   5
 None
 1.21A 1ee2B-2zi8A:
0.0		 1ee2B-2zi8A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 107
ILE A 105
LEU A 164
VAL A 117
 None
 0.86A 1fslA-2zi8A:
undetectable		 1fslA-2zi8A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 190
ALA A 203
LEU A 205
SER A 149
 None
 0.88A 1tz8C-2zi8A:
undetectable
1tz8D-2zi8A:
undetectable		 1tz8C-2zi8A:
17.94
1tz8D-2zi8A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 249
TYR A 256
SER A 288
 SDT  A 702 (-2.9A)
None
None
 0.92A 2gvcB-2zi8A:
undetectable		 2gvcB-2zi8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 249
TYR A 256
SER A 288
 SDT  A 702 (-2.9A)
None
None
 0.93A 2gvcE-2zi8A:
undetectable		 2gvcE-2zi8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 145
HIS A 200
VAL A 147
HIS A 215
 FE2  A 701 ( 3.3A)
SDT  A 702 (-4.0A)
None
FE2  A 701 ( 3.3A)
 0.92A 2wkoF-2zi8A:
undetectable		 2wkoF-2zi8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 202
ILE A 265
ASP A 264
LEU A   9
LEU A  51
 None
 1.07A 3cjtG-2zi8A:
undetectable		 3cjtG-2zi8A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 202
ILE A 265
ASP A 264
LEU A   9
LEU A  51
 None
 1.09A 3cjtK-2zi8A:
undetectable		 3cjtK-2zi8A:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 4 ILE A 213
PHE A 263
ILE A  11
THR A 209
 None
 1.14A 3ia4A-2zi8A:
undetectable		 3ia4A-2zi8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.96A 4a97C-2zi8A:
undetectable		 4a97C-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.93A 4a97D-2zi8A:
undetectable		 4a97D-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.90A 4a97G-2zi8A:
undetectable		 4a97G-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 136
VAL A 218
MET A 257
ILE A 265
 None
 0.96A 4a97I-2zi8A:
undetectable		 4a97I-2zi8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 113
LEU A   6
PHE A 204
 None
 0.57A 4dajB-2zi8A:
undetectable		 4dajB-2zi8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  52
VAL A  53
GLU A  12
GLY A  38
ALA A  35
 None
 1.18A 4fwdA-2zi8A:
undetectable		 4fwdA-2zi8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.69A 4ir0A-2zi8A:
8.3
4ir0B-2zi8A:
8.7		 4ir0A-2zi8A:
20.00
4ir0B-2zi8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.63A 4ir0A-2zi8A:
8.2
4ir0B-2zi8A:
8.7		 4ir0A-2zi8A:
20.00
4ir0B-2zi8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.62A 4jd1A-2zi8A:
8.4
4jd1B-2zi8A:
7.8		 4jd1A-2zi8A:
20.00
4jd1B-2zi8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.75A 4jd1A-2zi8A:
8.4
4jd1B-2zi8A:
7.8		 4jd1A-2zi8A:
20.00
4jd1B-2zi8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.62A 4jh3A-2zi8A:
8.1
4jh3B-2zi8A:
8.2		 4jh3A-2zi8A:
17.55
4jh3B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.61A 4jh3A-2zi8A:
8.0
4jh3B-2zi8A:
8.2		 4jh3A-2zi8A:
17.55
4jh3B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.60A 4jh4A-2zi8A:
8.1
4jh4B-2zi8A:
8.0		 4jh4A-2zi8A:
17.55
4jh4B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.60A 4jh4A-2zi8A:
8.1
4jh4B-2zi8A:
8.0		 4jh4A-2zi8A:
17.55
4jh4B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.61A 4jh5A-2zi8A:
8.1
4jh5B-2zi8A:
8.0		 4jh5A-2zi8A:
17.55
4jh5B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.61A 4jh5A-2zi8A:
8.1
4jh5B-2zi8A:
8.0		 4jh5A-2zi8A:
17.55
4jh5B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.63A 4jh6A-2zi8A:
8.2
4jh6B-2zi8A:
8.1		 4jh6A-2zi8A:
17.55
4jh6B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.63A 4jh6A-2zi8A:
8.2
4jh6B-2zi8A:
8.1		 4jh6A-2zi8A:
17.55
4jh6B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 215
TYR A 256
GLU A 266
HIS A 145
ALA A 203
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
FE2  A 701 ( 3.3A)
None
 0.62A 4jh8A-2zi8A:
8.1
4jh8B-2zi8A:
8.1		 4jh8A-2zi8A:
17.55
4jh8B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 145
ALA A 203
HIS A 215
TYR A 256
GLU A 266
 FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 3.3A)
None
FE2  A 701 ( 2.8A)
 0.61A 4jh8A-2zi8A:
8.1
4jh8B-2zi8A:
8.1		 4jh8A-2zi8A:
17.55
4jh8B-2zi8A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		3 / 3 CYH A  68
ASN A  70
LYS A   1
 None
 1.28A 4k50A-2zi8A:
undetectable		 4k50A-2zi8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2zi8 PROBABLE
BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE BPHC
(Mycobacterium
tuberculosis) 		3 / 4 ARG A  10
GLY A  65
GLU A 116
 None
 0.59A 4z2dB-2zi8A:
undetectable
4z2dC-2zi8A:
undetectable		 4z2dB-2zi8A:
21.82
4z2dC-2zi8A:
21.04