SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		4 / 8 PHE A 243
GLU A 264
ASP A  28
PRO A  49
 None
 0.83A 1hmyA-2zieA:
4.9		 1hmyA-2zieA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 ARG A  85
GLU A  82
PHE A 128
VAL A 263
VAL A  32
 None
 1.38A 1x70A-2zieA:
undetectable		 1x70A-2zieA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		4 / 7 LEU A 240
ASP A 241
LEU A 250
GLY A 247
 None
 0.98A 2qqcD-2zieA:
undetectable
2qqcE-2zieA:
undetectable		 2qqcD-2zieA:
19.71
2qqcE-2zieA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 261
SER A  40
PHE A  36
HIS A  25
SER A  35
 None
 1.48A 2xpwA-2zieA:
0.0		 2xpwA-2zieA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 PHE A 220
PRO A 242
VAL A  44
LEU A  93
ILE A  95
 None
 1.42A 2xrlA-2zieA:
undetectable		 2xrlA-2zieA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		10 / 12 ALA A  29
PRO A  49
PRO A 219
PHE A 220
GLY A 245
THR A 246
THR A 248
GLU A 264
LEU A 265
VAL A 266
 None
 0.72A 2zifA-2zieA:
39.6		 2zifA-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		11 / 12 ALA A  29
SER A  47
PRO A  49
PHE A 220
PHE A 243
GLY A 245
THR A 246
THR A 248
GLU A 264
LEU A 265
VAL A 266
 None
 0.44A 2zifA-2zieA:
39.6		 2zifA-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		8 / 12 SER A  47
PRO A  49
PHE A 220
GLY A 245
THR A 249
GLU A 264
LEU A 265
VAL A 266
 None
 1.39A 2zifA-2zieA:
39.6		 2zifA-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ALA A  29
PRO A 219
PHE A 220
GLY A 245
LEU A 265
VAL A 266
TYR A 269
 None
 0.92A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		10 / 12 ALA A  29
SER A  47
PRO A  49
PHE A 220
PHE A 243
GLY A 245
THR A 246
LEU A 265
VAL A 266
TYR A 269
 None
 0.38A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		3 / 3 ASP A  28
THR A 248
GLU A 264
 None
 0.47A 2zifB-2zieA:
38.4		 2zifB-2zieA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 PRO A 242
THR A  46
LEU A  76
ILE A 119
LEU A 126
 None
 1.24A 3a50E-2zieA:
undetectable		 3a50E-2zieA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 222
ALA A 244
ALA A 252
VAL A 229
LEU A  87
 None
 1.22A 3b0wB-2zieA:
undetectable		 3b0wB-2zieA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 ARG A  85
GLU A  82
PHE A 128
VAL A 263
VAL A  32
 None
 1.33A 3bjmB-2zieA:
3.1		 3bjmB-2zieA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 GLY A 245
GLU A 264
ASP A  28
ALA A  29
PRO A  49
 None
 0.91A 3fuuA-2zieA:
4.3		 3fuuA-2zieA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		3 / 3 GLY A 245
GLY A 247
THR A 249
 None
 0.38A 3si7B-2zieA:
undetectable		 3si7B-2zieA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		4 / 5 LEU A 192
ARG A 227
ARG A 230
ARG A 202
 None
 1.41A 3ticA-2zieA:
undetectable		 3ticA-2zieA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		4 / 8 TRP A  80
ARG A 122
LEU A  76
GLU A  75
 None
 1.35A 3zmdA-2zieA:
undetectable
3zmdB-2zieA:
undetectable		 3zmdA-2zieA:
20.66
3zmdB-2zieA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 ARG A  85
GLU A  82
PHE A 128
VAL A 263
VAL A  32
 None
 1.45A 4ffwB-2zieA:
undetectable		 4ffwB-2zieA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 9 PHE A 243
SER A  47
VAL A  83
VAL A  79
LEU A  93
 None
 1.17A 4wnvA-2zieA:
undetectable		 4wnvA-2zieA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		8 / 12 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
THR A 248
GLU A 264
TYR A 269
 None
 0.69A 5hfjA-2zieA:
19.6		 5hfjA-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 ALA A  29
PRO A  49
GLY A 245
THR A 248
TYR A 269
 None
 0.83A 5hfjB-2zieA:
20.1		 5hfjB-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 ALA A  29
PRO A  49
PHE A 243
GLY A 245
TYR A 269
 None
 0.50A 5hfjB-2zieA:
20.1		 5hfjB-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
THR A 248
TYR A 269
 None
 0.73A 5hfjC-2zieA:
20.2		 5hfjC-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ASP A  28
ALA A  29
PHE A 243
GLY A 245
THR A 248
GLU A 264
TYR A 269
 None
 0.79A 5hfjD-2zieA:
20.0		 5hfjD-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
GLU A 264
TYR A 269
 None
 0.63A 5hfjD-2zieA:
20.0		 5hfjD-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		6 / 12 ASP A  28
ALA A  29
LYS A 219
PHE A 243
GLY A 245
GLU A 264
 None
 1.46A 5hfjE-2zieA:
20.4		 5hfjE-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ASP A  28
ALA A  29
PHE A 243
GLY A 245
THR A 248
GLU A 264
TYR A 269
 None
 0.67A 5hfjE-2zieA:
20.4		 5hfjE-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
GLU A 264
TYR A 269
 None
 0.63A 5hfjF-2zieA:
20.1		 5hfjF-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		6 / 12 ALA A  29
PRO A  49
PHE A 243
GLY A 245
THR A 248
TYR A 269
 None
 0.70A 5hfjG-2zieA:
19.9		 5hfjG-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		7 / 12 ASP A  28
ALA A  29
PRO A  49
PHE A 243
GLY A 245
THR A 248
TYR A 269
 None
 0.72A 5hfjH-2zieA:
20.1		 5hfjH-2zieA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 11 PHE A 243
GLY A 245
GLU A 264
ASP A  28
PRO A  49
 None
 0.63A 5hjiA-2zieA:
3.5		 5hjiA-2zieA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 VAL A  32
HIS A  25
LEU A  24
LEU A 250
ARG A 259
 None
 1.38A 5hnxB-2zieA:
2.5		 5hnxB-2zieA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		3 / 3 PHE A  72
ASP A  74
LEU A  63
 None
 0.77A 5uhcC-2zieA:
undetectable		 5uhcC-2zieA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 9 VAL A  79
LEU A  33
GLY A 262
THR A  46
VAL A  44
 None
 1.34A 6czmA-2zieA:
undetectable
6czmB-2zieA:
undetectable		 6czmA-2zieA:
23.06
6czmB-2zieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 9 VAL A  79
LEU A  33
GLY A 262
THR A  46
VAL A  44
 None
 1.31A 6czmB-2zieA:
undetectable
6czmC-2zieA:
undetectable		 6czmB-2zieA:
23.06
6czmC-2zieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 9 VAL A  79
LEU A  33
GLY A 262
THR A  46
VAL A  44
 None
 1.32A 6czmD-2zieA:
undetectable
6czmE-2zieA:
undetectable		 6czmD-2zieA:
23.06
6czmE-2zieA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 2zie PUTATIVE
MODIFICATION
METHYLASE
(Thermus
thermophilus) 		5 / 12 ILE A  95
LEU A  73
ASP A  99
GLY A  98
ALA A 117
 None
 1.26A 6r2eH-2zieA:
undetectable		 6r2eH-2zieA:
23.31