SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.19A 1dhfA-2ziiA:
undetectable		 1dhfA-2ziiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.11A 1dhfB-2ziiA:
undetectable		 1dhfB-2ziiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 291
ALA A 332
ALA A 105
ARG A 107
GLU A 103
 None
 1.20A 2j0dA-2ziiA:
undetectable		 2j0dA-2ziiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.16A 2w3aB-2ziiA:
undetectable		 2w3aB-2ziiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.17A 2w3bB-2ziiA:
undetectable		 2w3bB-2ziiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		3 / 3 SER A 282
GLU A 266
ASP A 278
 None
 0.84A 2zthA-2ziiA:
undetectable		 2zthA-2ziiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.07A 3n0hA-2ziiA:
undetectable		 3n0hA-2ziiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 220
VAL A 224
MET A  76
VAL A 229
LEU A 225
 None
 0.97A 3ogpB-2ziiA:
undetectable		 3ogpB-2ziiA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.08A 3s3vA-2ziiA:
undetectable		 3s3vA-2ziiA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 261
ALA A 262
ILE A 160
LEU A  69
VAL A  73
 None
 0.75A 3u7sB-2ziiA:
undetectable		 3u7sB-2ziiA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 247
TYR A 294
VAL A 334
PHE A 296
 None
 1.14A 4a97E-2ziiA:
undetectable		 4a97E-2ziiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 261
GLY A 258
VAL A 264
CYH A  99
 None
 0.88A 4c5nA-2ziiA:
undetectable		 4c5nA-2ziiA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 333
LEU A 123
ARG A 126
ILE A 112
 None
 0.54A 4em2A-2ziiA:
2.9		 4em2A-2ziiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 265
LEU A 269
LEU A 272
ILE A 256
VAL A 306
 None
 1.22A 4f4dB-2ziiA:
undetectable		 4f4dB-2ziiA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 228
MET A  76
LEU A 255
ILE A 249
 None
 1.11A 4okxA-2ziiA:
undetectable		 4okxA-2ziiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 340
ARG A 126
ASP A 122
VAL A 334
 None
 1.09A 4xqeA-2ziiA:
undetectable		 4xqeA-2ziiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 340
ARG A 126
ASP A 122
VAL A 334
 None
 1.10A 4xqeB-2ziiA:
undetectable		 4xqeB-2ziiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 340
ARG A 126
ASP A 122
VAL A 334
 None
 1.09A 4xqgA-2ziiA:
undetectable		 4xqgA-2ziiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 340
ARG A 126
ASP A 122
VAL A 334
 None
 1.10A 4xqgB-2ziiA:
undetectable		 4xqgB-2ziiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		3 / 3 SER A 282
GLU A 266
ASP A 278
 None
 0.86A 4xudA-2ziiA:
undetectable		 4xudA-2ziiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2zii VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 11 MET A  70
LEU A 184
LEU A 140
ILE A 100
LEU A 147
 None
 1.03A 4zowA-2ziiA:
undetectable		 4zowA-2ziiA:
24.02