SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 8 ARG A 342
LEU A 352
VAL A 443
GLY A 444
 None
 1.05A 1hrkA-2zj4A:
3.7		 1hrkA-2zj4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		3 / 3 ARG A 501
THR A 383
VAL A 386
 None
 0.98A 1hxbA-2zj4A:
undetectable		 1hxbA-2zj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 12 ILE A 505
ALA A 488
ILE A 646
LEU A 512
PRO A 513
 None
 1.15A 1jolB-2zj4A:
undetectable		 1jolB-2zj4A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 LEU A 484
VAL A 443
VAL A 461
GLY A 460
LEU A 370
 None
 1.40A 1lwfA-2zj4A:
undetectable		 1lwfA-2zj4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 ILE A 634
ILE A 592
PRO A 615
VAL A 588
ILE A 589
 None
 1.07A 2avoA-2zj4A:
undetectable		 2avoA-2zj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 7 ARG A 501
ASP A 595
ASP A 641
TYR A 546
 None
 1.12A 2e5dA-2zj4A:
undetectable
2e5dB-2zj4A:
undetectable		 2e5dA-2zj4A:
21.48
2e5dB-2zj4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 7 ASP A 641
TYR A 546
ARG A 501
ASP A 595
 None
 1.10A 2e5dA-2zj4A:
undetectable
2e5dB-2zj4A:
undetectable		 2e5dA-2zj4A:
21.48
2e5dB-2zj4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		3 / 3 ARG A 501
THR A 383
VAL A 386
 None
 0.92A 2qakA-2zj4A:
undetectable		 2qakA-2zj4A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 ILE A 634
ILE A 592
PRO A 615
VAL A 588
ILE A 589
 None
 1.16A 2r5qA-2zj4A:
undetectable		 2r5qA-2zj4A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 ILE A 634
ILE A 592
PRO A 615
VAL A 588
ILE A 589
 None
 1.17A 2r5qC-2zj4A:
undetectable		 2r5qC-2zj4A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 ILE A 634
ILE A 592
PRO A 615
VAL A 588
ILE A 589
 None
 0.98A 3d1yB-2zj4A:
undetectable		 3d1yB-2zj4A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 6 LEU A 368
ALA A 488
LEU A 390
THR A 391
 None
 1.04A 3rozA-2zj4A:
3.7		 3rozA-2zj4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		3 / 3 TYR A 598
LEU A 552
ARG A 544
 None
 0.67A 3sufB-2zj4A:
undetectable		 3sufB-2zj4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 5 PHE A 487
ALA A 488
THR A 391
LEU A 370
 None
 1.02A 3t3zC-2zj4A:
undetectable		 3t3zC-2zj4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 11 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.87A 4e47A-2zj4A:
undetectable		 4e47A-2zj4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 11 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.85A 4e47B-2zj4A:
undetectable		 4e47B-2zj4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 11 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.90A 4e47C-2zj4A:
undetectable		 4e47C-2zj4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 11 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.86A 4jdsB-2zj4A:
undetectable		 4jdsB-2zj4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 11 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.90A 4jdsC-2zj4A:
undetectable		 4jdsC-2zj4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 12 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.85A 4jlgA-2zj4A:
undetectable		 4jlgA-2zj4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		3 / 3 PRO A 467
ASN A 447
HIS A 462
 None
 0.84A 4ma3H-2zj4A:
undetectable
4ma3L-2zj4A:
undetectable		 4ma3H-2zj4A:
19.23
4ma3L-2zj4A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 8 ILE A 463
GLN A 480
THR A 425
THR A 428
 None
None
AGP  A   1 (-3.1A)
None
 0.82A 4n16A-2zj4A:
undetectable		 4n16A-2zj4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 12 THR A 474
GLU A 553
GLU A 468
LYS A 675
ASP A 666
 None
None
None
AGP  A   1 ( 4.9A)
None
 1.50A 4njjA-2zj4A:
0.7		 4njjA-2zj4A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 11 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.84A 5ayfA-2zj4A:
undetectable		 5ayfA-2zj4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 6 ALA A 660
GLN A 325
SER A 321
ASP A 668
 None
 1.02A 5c6pA-2zj4A:
undetectable		 5c6pA-2zj4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 12 LEU A 419
ILE A 362
VAL A 443
GLY A 444
ILE A 445
 None
 0.73A 5j2tC-2zj4A:
3.9		 5j2tC-2zj4A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 ILE A 634
ILE A 592
PRO A 615
VAL A 588
ILE A 589
 None
 0.97A 5kr2D-2zj4A:
undetectable		 5kr2D-2zj4A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		4 / 8 LEU A 529
LYS A 635
ILE A 627
THR A 633
 None
 1.05A 5ljbA-2zj4A:
undetectable		 5ljbA-2zj4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 12 GLU A 553
ALA A 476
SER A 473
GLY A 380
LEU A 419
 None
 1.19A 5m5cB-2zj4A:
3.8		 5m5cB-2zj4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 10 GLU A 553
ALA A 476
SER A 473
GLY A 380
LEU A 419
 None
 1.22A 5m5cE-2zj4A:
4.0		 5m5cE-2zj4A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1
(Homo
sapiens) 		5 / 9 ILE A 463
ALA A 465
GLY A 466
GLY A 470
ASN A 447
 None
 0.81A 6nm4B-2zj4A:
undetectable		 6nm4B-2zj4A:
18.84