SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 4 HIS A 165
LEU A 408
LEU A 414
LEU A 463
 None
 1.09A 1a4lD-2zj8A:
undetectable		 1a4lD-2zj8A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 PHE A 436
GLU A 160
VAL A 161
ILE A 136
PHE A 425
 None
 1.08A 1c9hA-2zj8A:
undetectable		 1c9hA-2zj8A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 8 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.02A 1d4yB-2zj8A:
undetectable		 1d4yB-2zj8A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 681
VAL A 654
LEU A 651
ALA A 694
 None
 0.88A 1fiqC-2zj8A:
undetectable		 1fiqC-2zj8A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 519
ALA A 574
ASN A 511
ILE A 515
THR A 573
 None
 1.27A 1j3jA-2zj8A:
undetectable		 1j3jA-2zj8A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 4 HIS A 517
ALA A 574
PHE A 516
GLY A 514
 None
 1.29A 1mj2B-2zj8A:
undetectable		 1mj2B-2zj8A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 4 HIS A 517
ALA A 574
PHE A 516
GLY A 514
 None
 1.34A 1mj2D-2zj8A:
undetectable		 1mj2D-2zj8A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 4 HIS A 517
ALA A 574
PHE A 516
GLY A 514
 None
 1.31A 1mjoB-2zj8A:
0.6		 1mjoB-2zj8A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 460
VAL A 430
ILE A 433
GLU A 411
LEU A 419
 None
 1.09A 1mrqA-2zj8A:
undetectable		 1mrqA-2zj8A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 4 ILE A  94
LEU A  96
VAL A  98
ALA A 101
 None
 0.92A 1mz9A-2zj8A:
undetectable		 1mz9A-2zj8A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 128
SER A 127
TYR A 490
LEU A 142
ALA A 122
 None
 1.08A 1pxxC-2zj8A:
undetectable		 1pxxC-2zj8A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 160
SER A 176
GLY A 151
SER A 406
ILE A 150
 None
 1.11A 1q8jB-2zj8A:
2.4		 1q8jB-2zj8A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 LYS A 615
ILE A 515
THR A 495
 None
 0.81A 1rx3A-2zj8A:
undetectable		 1rx3A-2zj8A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 11 TYR A 427
PHE A 436
GLU A 160
VAL A 161
PHE A 425
 None
 1.31A 2dg3A-2zj8A:
undetectable		 2dg3A-2zj8A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 9 LEU A 185
LEU A 189
ILE A 172
LEU A 159
ILE A 150
 None
 1.29A 2f78B-2zj8A:
undetectable		 2f78B-2zj8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 9 LEU A 185
LEU A 189
ILE A 172
LEU A 159
ILE A 150
 None
 1.28A 2f7aA-2zj8A:
undetectable		 2f7aA-2zj8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.94A 2f81B-2zj8A:
undetectable		 2f81B-2zj8A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.96A 2ienB-2zj8A:
undetectable		 2ienB-2zj8A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 9 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.96A 2o4pB-2zj8A:
undetectable		 2o4pB-2zj8A:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.00A 2pymA-2zj8A:
undetectable		 2pymA-2zj8A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 11 LEU A  65
HIS A  62
LEU A  37
VAL A   8
ILE A  55
 None
 1.20A 2uxoB-2zj8A:
2.0		 2uxoB-2zj8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 PHE A 316
ALA A 338
ALA A 240
LEU A 257
VAL A 261
 None
 1.42A 2wuzA-2zj8A:
undetectable		 2wuzA-2zj8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 PHE A 316
ALA A 338
ALA A 240
LEU A 257
VAL A 261
 None
 1.41A 2wuzB-2zj8A:
undetectable		 2wuzB-2zj8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 164
LEU A 167
GLN A 445
ILE A 179
 None
 0.94A 3cldB-2zj8A:
undetectable		 3cldB-2zj8A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 248
ARG A 247
GLY A 598
PRO A 597
 None
 1.10A 3hcrA-2zj8A:
3.7		 3hcrA-2zj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 ASP A 599
ARG A 602
ARG A 248
 None
 0.76A 3k37A-2zj8A:
undetectable		 3k37A-2zj8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.12A 3mwsB-2zj8A:
undetectable		 3mwsB-2zj8A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.97A 3ndtC-2zj8A:
undetectable		 3ndtC-2zj8A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 460
LEU A 463
PRO A 479
ILE A 469
 None
 0.96A 3s56B-2zj8A:
undetectable		 3s56B-2zj8A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.02A 3tkgB-2zj8A:
undetectable		 3tkgB-2zj8A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 681
VAL A 654
LEU A 651
ALA A 694
 None
 0.80A 3uniB-2zj8A:
undetectable		 3uniB-2zj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 537
LEU A 538
TYR A 593
GLU A 534
 None
 1.16A 3zmdA-2zj8A:
5.8
3zmdB-2zj8A:
6.0		 3zmdA-2zj8A:
14.16
3zmdB-2zj8A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 ARG A 634
GLU A 616
LYS A 619
ARG A 485
 None
 1.24A 4bqfB-2zj8A:
undetectable		 4bqfB-2zj8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.87A 4dqfB-2zj8A:
undetectable		 4dqfB-2zj8A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 LYS A 615
ILE A 515
THR A 495
 None
 0.82A 4gh8A-2zj8A:
undetectable		 4gh8A-2zj8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 150
ILE A 360
VAL A 195
LEU A  43
ILE A 147
 None
 0.86A 4km2A-2zj8A:
undetectable		 4km2A-2zj8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 ILE A 342
MET A 365
ARG A 368
 None
 0.94A 4lnwA-2zj8A:
undetectable		 4lnwA-2zj8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 ILE A 342
MET A 365
ARG A 368
 None
 0.95A 4lnxA-2zj8A:
undetectable		 4lnxA-2zj8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  32
ALA A  59
ILE A 194
ALA A  42
ILE A  46
 None
 0.91A 4o2bD-2zj8A:
undetectable		 4o2bD-2zj8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.90A 4qgiB-2zj8A:
undetectable		 4qgiB-2zj8A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 TYR A 639
ARG A 634
LYS A 638
 None
 1.23A 4wq5B-2zj8A:
undetectable		 4wq5B-2zj8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 4 ARG A  97
GLY A  95
GLU A  92
 None
 0.61A 4z2dB-2zj8A:
1.9
4z2dC-2zj8A:
2.4		 4z2dB-2zj8A:
21.22
4z2dC-2zj8A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 PHE A 516
THR A 573
ASN A 582
LEU A 633
ARG A 636
 None
 1.41A 4z7fC-2zj8A:
undetectable		 4z7fC-2zj8A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.85A 5eckA-2zj8A:
undetectable		 5eckA-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.92A 5eckD-2zj8A:
undetectable		 5eckD-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.88A 5eclA-2zj8A:
2.1		 5eclA-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.88A 5eclD-2zj8A:
undetectable		 5eclD-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 6 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.98A 5ecoA-2zj8A:
undetectable		 5ecoA-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 7 ALA A 326
THR A 327
VAL A 244
HIS A 300
 None
 0.82A 5ecoD-2zj8A:
1.7		 5ecoD-2zj8A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 419
LEU A 482
ASN A 466
ALA A 496
ILE A 617
 None
 1.18A 5eypB-2zj8A:
undetectable		 5eypB-2zj8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 PHE A 436
GLU A 160
VAL A 161
ILE A 136
PHE A 425
 None
 1.00A 5hkgA-2zj8A:
undetectable		 5hkgA-2zj8A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.06A 5kqyA-2zj8A:
undetectable		 5kqyA-2zj8A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.03A 5kr1A-2zj8A:
undetectable		 5kr1A-2zj8A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 11 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.93A 5kr2B-2zj8A:
undetectable		 5kr2B-2zj8A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 11 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.12A 5lg3A-2zj8A:
undetectable		 5lg3A-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.09A 5lg3B-2zj8A:
3.2		 5lg3B-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.13A 5lg3C-2zj8A:
3.3		 5lg3C-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.10A 5lg3D-2zj8A:
3.3		 5lg3D-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.12A 5lg3F-2zj8A:
undetectable		 5lg3F-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.12A 5lg3G-2zj8A:
undetectable		 5lg3G-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 10 ILE A 673
PHE A 667
VAL A 654
THR A 691
ILE A 687
 None
 1.12A 5lg3H-2zj8A:
undetectable		 5lg3H-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 9 ILE A 673
PHE A 667
VAL A 654
ILE A 687
 None
 0.84A 5lg3I-2zj8A:
3.4		 5lg3I-2zj8A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 GLU A 544
ARG A 656
LEU A 578
GLU A 588
TYR A 593
 None
 1.50A 5mqtC-2zj8A:
2.9		 5mqtC-2zj8A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 7 ILE A 491
LEU A 518
PHE A 551
THR A 573
 None
 0.94A 5vc0A-2zj8A:
undetectable		 5vc0A-2zj8A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A  32
ALA A  59
ILE A 194
ALA A  42
ILE A  46
 None
 0.92A 5xiwB-2zj8A:
undetectable		 5xiwB-2zj8A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 8 LEU A 304
ILE A 334
LEU A 257
ALA A 254
 None
 0.77A 5y7pC-2zj8A:
undetectable		 5y7pC-2zj8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 1.07A 6dgxB-2zj8A:
undetectable		 6dgxB-2zj8A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 681
ALA A 661
GLY A 655
VAL A 692
ILE A 687
 None
 0.83A 6dilB-2zj8A:
undetectable		 6dilB-2zj8A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		3 / 3 VAL A 312
GLU A 313
ILE A 321
 None
 0.66A 6f7lB-2zj8A:
undetectable		 6f7lB-2zj8A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2zj8 PUTATIVE SKI2-TYPE
HELICASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 189
ILE A 117
MET A 166
GLY A 168
 None
 0.90A 6hd6A-2zj8A:
undetectable		 6hd6A-2zj8A:
7.84