SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zj9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
LYS A 315
GLY A 317
ALA A 318
 None
 0.43A 1i2wA-2zj9A:
13.8		 1i2wA-2zj9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 317
ALA A 318
 None
 0.40A 1i2wB-2zj9A:
5.3		 1i2wB-2zj9A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2zj9 AMPC
(Escherichia
coli) 		5 / 11 LEU A 357
VAL A 234
TYR A 325
PHE A 328
TRP A 312
 None
 1.44A 1klmA-2zj9A:
undetectable		 1klmA-2zj9A:
21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		7 / 10 GLN A 120
TYR A 150
ASN A 152
TYR A 221
LYS A 315
THR A 316
GLY A 317
 None
 0.31A 1kvlA-2zj9A:
62.1		 1kvlA-2zj9A:
97.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 10 GLY A  63
GLN A 120
ASN A 152
TYR A 221
THR A 316
GLY A 317
 None
 1.23A 1kvlA-2zj9A:
62.1		 1kvlA-2zj9A:
97.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2zj9 AMPC
(Escherichia
coli) 		3 / 3 TRP A  93
TYR A  92
LEU A 109
 None
 1.10A 1kxhA-2zj9A:
undetectable		 1kxhA-2zj9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.86A 2o4lB-2zj9A:
undetectable		 2o4lB-2zj9A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2zj9 AMPC
(Escherichia
coli) 		4 / 7 PHE A 158
ALA A  77
LEU A  73
PHE A 170
 None
 1.15A 2vcvA-2zj9A:
undetectable		 2vcvA-2zj9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 2zj9 AMPC
(Escherichia
coli) 		4 / 8 PHE A 158
LEU A 106
ARG A  80
GLY A  74
 None
 0.85A 2vdbA-2zj9A:
undetectable		 2vdbA-2zj9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 PHE A  69
MET A 174
THR A 176
VAL A 223
ILE A 189
 None
 1.30A 3elzA-2zj9A:
undetectable		 3elzA-2zj9A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
THR A 316
GLY A 317
 None
 0.40A 3huoA-2zj9A:
14.8		 3huoA-2zj9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 317
THR A 319
ARG A 349
 None
 1.00A 3mzeA-2zj9A:
14.6		 3mzeA-2zj9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 316
GLY A 317
THR A 319
 None
 0.73A 3mzeA-2zj9A:
14.6		 3mzeA-2zj9A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 2zj9 AMPC
(Escherichia
coli) 		5 / 10 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.90A 3oxwC-2zj9A:
undetectable		 3oxwC-2zj9A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 2zj9 AMPC
(Escherichia
coli) 		5 / 11 LEU A  62
ILE A 155
GLY A  71
VAL A  72
VAL A 223
 None
 0.83A 3oxxD-2zj9A:
undetectable		 3oxxD-2zj9A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
ASN A 152
LYS A 315
THR A 316
GLY A 317
ALA A 318
 None
 0.51A 3sh8A-2zj9A:
14.2		 3sh8A-2zj9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
LYS A  67
ASN A 152
LYS A 315
GLY A 317
ALA A 318
 None
 0.60A 3sh8B-2zj9A:
14.1		 3sh8B-2zj9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 2zj9 AMPC
(Escherichia
coli) 		5 / 9 LEU A  85
ALA A 162
GLY A 156
ILE A 155
LEU A 107
 None
 1.01A 3u7sA-2zj9A:
undetectable		 3u7sA-2zj9A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 GLN A 172
THR A 176
ILE A 189
ASN A 190
PHE A 179
 None
 1.33A 4c49B-2zj9A:
undetectable		 4c49B-2zj9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 2zj9 AMPC
(Escherichia
coli) 		5 / 10 ASN A 152
LYS A 315
THR A 316
GLY A 317
ALA A 318
 None
 0.35A 4fh2A-2zj9A:
15.2		 4fh2A-2zj9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
ASN A 152
LYS A 315
THR A 316
GLY A 317
ALA A 318
 None
 0.46A 4n9kA-2zj9A:
4.9		 4n9kA-2zj9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
ASN A 152
LYS A 315
THR A 316
GLY A 317
ALA A 318
 None
 0.50A 4n9kB-2zj9A:
5.1		 4n9kB-2zj9A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 2zj9 AMPC
(Escherichia
coli) 		4 / 8 ILE A 356
ILE A 336
ALA A 327
TRP A 354
 None
 0.96A 4ou1A-2zj9A:
undetectable		 4ou1A-2zj9A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM7_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 LYS A  67
ASN A 152
LYS A 315
GLY A 317
ALA A 318
 None
 0.50A 4pm7A-2zj9A:
14.9		 4pm7A-2zj9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM9_A_CE3A301_1
(BETA-LACTAMASE
CTX-M-14)		 2zj9 AMPC
(Escherichia
coli) 		5 / 12 ASN A 152
LYS A 315
THR A 316
GLY A 317
ALA A 318
 None
 0.44A 4pm9A-2zj9A:
14.9		 4pm9A-2zj9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2zj9 AMPC
(Escherichia
coli) 		3 / 3 GLU A 272
TRP A 312
ASN A 346
 IPA  A 362 (-4.3A)
None
None
 0.98A 5dv4A-2zj9A:
undetectable		 5dv4A-2zj9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 11 SER A  64
ASN A 152
LYS A 315
THR A 316
GLY A 317
ALA A 318
 None
 0.48A 5ghzA-2zj9A:
13.9		 5ghzA-2zj9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6C_A_9F2A301_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
ARG A 214
ARG A 349
LYS A 315
THR A 316
GLY A 317
 None
 1.11A 6b6cA-2zj9A:
14.3		 6b6cA-2zj9A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 2zj9 AMPC
(Escherichia
coli) 		6 / 12 SER A  64
ARG A 214
ARG A 349
LYS A 315
THR A 316
GLY A 317
 None
 1.13A 6b6eA-2zj9A:
14.0		 6b6eA-2zj9A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 2zj9 AMPC
(Escherichia
coli) 		4 / 6 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 IPA  A 362 ( 4.6A)
None
None
None
 1.04A 6brdB-2zj9A:
undetectable		 6brdB-2zj9A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2zj9 AMPC
(Escherichia
coli) 		3 / 3 TYR A 135
ALA A 160
LEU A 216
 None
 0.73A 6d9kF-2zj9A:
undetectable		 6d9kF-2zj9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2zj9 AMPC
(Escherichia
coli) 		4 / 5 PHE A  69
VAL A 191
MET A 230
VAL A  65
 None
 1.37A 6ekzA-2zj9A:
undetectable		 6ekzA-2zj9A:
11.27