SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ALA A 160
ASP A 162
GLY A 154
ILE A 153
VAL A 128
 None
 1.16A 1hpvB-2zk7A:
undetectable		 1hpvB-2zk7A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 TYR A 108
VAL A 146
SER A 148
SER A 131
LEU A 245
 None
 1.39A 1rk3A-2zk7A:
undetectable		 1rk3A-2zk7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 ARG A  26
SER A  73
TYR A  71
 None
 0.58A 1x70A-2zk7A:
4.2		 1x70A-2zk7A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 TYR A 108
VAL A 146
SER A 148
SER A 131
LEU A 245
 None
 1.38A 2zlcA-2zk7A:
undetectable		 2zlcA-2zk7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A  14
ALA A  22
ASP A  53
VAL A  54
VAL A 103
 None
 1.04A 3dmfA-2zk7A:
6.1		 3dmfA-2zk7A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 LEU A   5
GLU A  30
SER A 228
PHE A 225
 None
 1.41A 3i9jB-2zk7A:
undetectable		 3i9jB-2zk7A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 TYR A 108
VAL A 146
SER A 148
SER A 131
LEU A 245
 None
 1.39A 3vt3A-2zk7A:
undetectable		 3vt3A-2zk7A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 TYR A 108
VAL A 146
SER A 148
SER A 131
LEU A 245
 None
 1.35A 3vt7A-2zk7A:
undetectable		 3vt7A-2zk7A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASN A 170
ILE A 159
SER A 126
ALA A 164
 None
 0.89A 4eyzA-2zk7A:
undetectable		 4eyzA-2zk7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASN A 170
ILE A 159
SER A 126
ALA A 164
 None
 0.88A 4eyzB-2zk7A:
undetectable		 4eyzB-2zk7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 VAL A  28
GLY A  31
LYS A  33
 None
 0.76A 4k50A-2zk7A:
undetectable		 4k50A-2zk7A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ASN A  56
VAL A  60
ILE A 101
ILE A 100
SER A 148
 None
 1.47A 4xueA-2zk7A:
8.0		 4xueA-2zk7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2zk7 GLUCOSE
1-DEHYDROGENASE
RELATED PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ALA A  62
ILE A  35
LEU A  37
ILE A  11
ILE A  74
 None
 0.99A 5nunA-2zk7A:
undetectable		 5nunA-2zk7A:
17.02