SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		3 / 3 SER A 575
GLU A 571
ASP A 474
 None
 0.83A 2avdB-2zkgA:
undetectable		 2avdB-2zkgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		4 / 6 PRO A 570
LEU A 506
ARG A 581
GLY A 485
 None
 0.98A 2hs2B-2zkgA:
undetectable		 2hs2B-2zkgA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		5 / 12 ILE A 454
VAL A 537
LEU A 584
TYR A 483
PHE A 481
 None
 1.49A 2no0A-2zkgA:
undetectable		 2no0A-2zkgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		5 / 12 ALA A 462
GLY A 456
HIS A 447
LEU A 515
TYR A 582
 None
 1.25A 3bxoA-2zkgA:
undetectable		 3bxoA-2zkgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		5 / 12 ALA A 462
GLY A 456
HIS A 447
LEU A 515
TYR A 582
 None
 1.32A 3bxoB-2zkgA:
undetectable		 3bxoB-2zkgA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		5 / 10 ASN A 509
GLY A 485
TYR A 483
GLY A 461
ALA A 462
 None
 1.38A 3pp7B-2zkgA:
undetectable		 3pp7B-2zkgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		4 / 8 VAL A 566
TYR A 568
TYR A 582
TRP A 580
 None
 1.16A 4q0bA-2zkgA:
undetectable		 4q0bA-2zkgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		3 / 3 VAL A 429
HIS A 447
VAL A 540
 None
 0.53A 5jmnC-2zkgA:
undetectable		 5jmnC-2zkgA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		3 / 3 GLU A 443
HIS A 450
ARG A 438
 None
 0.76A 5uunA-2zkgA:
undetectable		 5uunA-2zkgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		3 / 3 ARG A 558
ARG A 586
ARG A 601
 None
 0.96A 5vcgA-2zkgA:
undetectable		 5vcgA-2zkgA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2zkg E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Mus
musculus) 		3 / 3 TYR A 563
ASP A 588
ASP A 560
 None
 0.83A 5x6yA-2zkgA:
undetectable		 5x6yA-2zkgA:
13.13