SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A 148
ILE A 179
LYS A 178
THR A 156
 None
None
SO4  A 503 ( 3.4A)
None
 0.93A 1sbrA-2zkiA:
undetectable		 1sbrA-2zkiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 6 PRO A 143
GLY A 145
PRO A 160
GLY A 162
 None
 0.87A 2jklB-2zkiA:
undetectable		 2jklB-2zkiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 PRO A 143
GLY A 145
PRO A 160
GLY A 162
 None
 0.86A 2jklD-2zkiA:
undetectable		 2jklD-2zkiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 PRO A 143
GLY A 145
PRO A 160
GLY A 162
 None
 0.85A 2jklE-2zkiA:
undetectable		 2jklE-2zkiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		3 / 3 LYS A  22
ARG A  38
VAL A   9
 None
SO4  A 502 (-3.2A)
None
 1.11A 2r2vC-2zkiA:
undetectable
2r2vD-2zkiA:
undetectable		 2r2vC-2zkiA:
10.66
2r2vD-2zkiA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  86
GLY A  88
LEU A  93
GLY A  77
SER A  78
 None
 1.03A 3g2oA-2zkiA:
undetectable		 3g2oA-2zkiA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A  86
GLY A  88
LEU A  93
GLY A  77
SER A  78
 None
 0.98A 3g2oB-2zkiA:
undetectable		 3g2oB-2zkiA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A 186
GLY A  32
ALA A  33
PRO A 109
 None
 0.82A 4eyrB-2zkiA:
undetectable		 4eyrB-2zkiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 4 ILE A 179
ASP A 173
ARG A 181
THR A 156
 None
None
SO4  A 505 ( 2.9A)
None
 1.24A 4nx6A-2zkiA:
undetectable		 4nx6A-2zkiA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 4 ILE A 179
ASP A 173
ARG A 181
THR A 156
 None
None
SO4  A 505 ( 2.9A)
None
 1.24A 4nx7A-2zkiA:
undetectable		 4nx7A-2zkiA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 5 GLY A 157
THR A 156
HIS A 123
GLY A 167
 None
 0.82A 4v20A-2zkiA:
undetectable		 4v20A-2zkiA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 5 ILE A 187
VAL A 142
ILE A 140
VAL A 190
 None
 0.62A 4xdtA-2zkiA:
undetectable		 4xdtA-2zkiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A  25
GLY A  27
ILE A 187
ARG A 181
LEU A  20
 None
None
None
SO4  A 505 ( 2.9A)
None
 0.99A 5fa8A-2zkiA:
undetectable		 5fa8A-2zkiA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 7 GLY A 162
ALA A 163
GLY A 184
ILE A 187
 None
 0.59A 5kqyB-2zkiA:
undetectable		 5kqyB-2zkiA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN
(Sulfurisphaera
tokodaii) 		4 / 8 GLY A 162
ALA A 163
GLY A 184
ILE A 187
 None
 0.59A 5kr1B-2zkiA:
undetectable		 5kr1B-2zkiA:
18.84