SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 LEU A 348
ALA A 341
LEU A 255
ALA A 259
ILE A 291
 None
None
None
ADP  A 501 ( 4.6A)
None
 0.88A 1fk6A-2zkjA:
undetectable		 1fk6A-2zkjA:
12.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		4 / 8 LEU A  65
TYR A  92
HIS A 127
ARG A 166
 None
 0.71A 2bu8A-2zkjA:
47.0		 2bu8A-2zkjA:
65.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.07A 2j7xA-2zkjA:
undetectable		 2j7xA-2zkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 GLU A 373
LEU A  35
ARG A  64
ILE A 179
GLY A  44
 None
 1.29A 2j7xA-2zkjA:
undetectable		 2j7xA-2zkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 LEU A 172
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.28A 2j7xA-2zkjA:
undetectable		 2j7xA-2zkjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		3 / 3 LEU A 334
PRO A 335
ARG A 261
 ADP  A 501 (-4.0A)
None
ADP  A 501 (-3.7A)
 0.59A 2qd5A-2zkjA:
undetectable		 2qd5A-2zkjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.07A 2yjaB-2zkjA:
undetectable		 2yjaB-2zkjA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 VAL A 298
GLY A 297
GLY A 355
THR A 358
LEU A 350
 ADP  A 501 (-4.7A)
ADP  A 501 ( 4.6A)
None
ADP  A 501 (-3.8A)
None
 1.34A 3dh0A-2zkjA:
undetectable		 3dh0A-2zkjA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		4 / 6 ILE A 372
ILE A 362
GLY A 346
VAL A 244
 None
 0.98A 3n3iA-2zkjA:
undetectable		 3n3iA-2zkjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.09A 3q95B-2zkjA:
undetectable		 3q95B-2zkjA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		4 / 7 LEU A 287
LEU A 282
PRO A 238
ILE A 239
 None
 0.90A 3s56B-2zkjA:
undetectable		 3s56B-2zkjA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 GLU A 373
LEU A  35
ARG A  64
ILE A 179
GLY A  44
 None
 1.29A 4j26A-2zkjA:
undetectable		 4j26A-2zkjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 LEU A 172
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.30A 4j26A-2zkjA:
undetectable		 4j26A-2zkjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 11 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.06A 4pxmB-2zkjA:
undetectable		 4pxmB-2zkjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 11 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.02A 5dxbB-2zkjA:
undetectable		 5dxbB-2zkjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 GLU A 373
ARG A  64
ILE A 179
GLY A  44
LEU A  41
 None
 1.03A 5gtrA-2zkjA:
undetectable		 5gtrA-2zkjA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 THR A  82
VAL A  85
VAL A  88
ASP A 143
PHE A 162
 None
 1.21A 6iblA-2zkjA:
2.1		 6iblA-2zkjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2zkj [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 4
(Homo
sapiens) 		5 / 12 THR A  82
VAL A  85
VAL A  88
ASP A 143
PHE A 162
 None
 1.21A 6iblB-2zkjA:
undetectable		 6iblB-2zkjA:
21.93