SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 4 ILE X 371
MET X 420
VAL X 536
GLY X 363
 None
 1.34A 1e06B-2zkmX:
undetectable		 1e06B-2zkmX:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		5 / 9 LEU X 769
LEU X 795
ILE X 793
ARG X 762
ILE X 764
 None
 1.10A 2f7aB-2zkmX:
undetectable		 2f7aB-2zkmX:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 PHE X 203
PHE X 170
PHE X 174
 None
 0.86A 2od9A-2zkmX:
undetectable		 2od9A-2zkmX:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 LEU X 448
PRO X 449
LEU X 318
 None
 0.61A 2po5B-2zkmX:
3.6		 2po5B-2zkmX:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 LEU X 448
PRO X 449
LEU X 318
 None
 0.54A 2po7B-2zkmX:
2.4		 2po7B-2zkmX:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 PHE X 203
PHE X 170
PHE X 174
 None
 0.86A 2qqgA-2zkmX:
undetectable		 2qqgA-2zkmX:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 6 LYS X 124
GLU X 128
LEU X  96
THR X  98
 None
 1.02A 2roxB-2zkmX:
2.8		 2roxB-2zkmX:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 7 ILE X 460
LEU X 405
PHE X 407
THR X 426
 None
 1.21A 2zxwN-2zkmX:
undetectable
2zxwW-2zkmX:
undetectable		 2zxwN-2zkmX:
20.22
2zxwW-2zkmX:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_B_FOLB270_0
(PTERIDINE REDUCTASE)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		5 / 11 SER X 560
CYH X 621
PHE X 588
TYR X 591
GLU X 574
 None
 1.49A 3bmcB-2zkmX:
0.2		 3bmcB-2zkmX:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_D_FOLD270_0
(PTERIDINE REDUCTASE)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		5 / 12 SER X 560
CYH X 621
PHE X 588
TYR X 591
GLU X 574
 None
 1.35A 3bmcD-2zkmX:
0.7		 3bmcD-2zkmX:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 ASN X  92
ASP X  83
GLN X  79
 None
 0.73A 3eeyC-2zkmX:
3.4		 3eeyC-2zkmX:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 ASN X  92
ASP X  83
GLN X  79
 None
 0.73A 3eeyD-2zkmX:
undetectable		 3eeyD-2zkmX:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 ASN X  92
ASP X  83
GLN X  79
 None
 0.72A 3eeyE-2zkmX:
undetectable		 3eeyE-2zkmX:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 LEU X 190
PRO X 191
LEU X 185
 None
 0.42A 3hcrA-2zkmX:
3.6		 3hcrA-2zkmX:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 LEU X 448
PRO X 449
LEU X 318
 None
 0.46A 3hcrA-2zkmX:
3.6		 3hcrA-2zkmX:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		5 / 12 VAL X 108
ILE X 763
GLY X 760
SER X 780
ALA X 640
 None
 0.96A 3sufD-2zkmX:
undetectable		 3sufD-2zkmX:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 7 ASP X 381
GLY X 363
THR X 373
PHE X 383
 None
 1.17A 3vnsA-2zkmX:
3.1		 3vnsA-2zkmX:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 6 ARG X 748
ILE X 682
VAL X 684
LEU X 791
 None
 1.11A 4em2A-2zkmX:
undetectable		 4em2A-2zkmX:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 8 VAL X 701
VAL X 684
ILE X 793
LEU X 769
 None
 0.91A 4jq1B-2zkmX:
7.6		 4jq1B-2zkmX:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 8 TYR X  16
VAL X  13
LEU X  38
LEU X  47
 None
 1.01A 4jtrA-2zkmX:
7.5		 4jtrA-2zkmX:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 LYS X 461
ILE X 404
ILE X 323
 None
 0.58A 4y0qA-2zkmX:
undetectable		 4y0qA-2zkmX:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		5 / 11 LEU X 131
VAL X 134
LEU X  17
GLY X  44
LEU X  47
 None
 1.16A 4zbqA-2zkmX:
undetectable		 4zbqA-2zkmX:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 4 LEU X 215
ARG X 218
ILE X 725
PHE X 689
 None
 1.32A 5kirB-2zkmX:
undetectable		 5kirB-2zkmX:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		3 / 3 ARG X  65
PHE X  72
LEU X 131
 None
 0.68A 5veuA-2zkmX:
undetectable		 5veuA-2zkmX:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2zkm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-2
(Homo
sapiens) 		4 / 5 HIS X 327
ASP X 607
GLY X 334
ASN X 627
 None
 1.21A 5x7pB-2zkmX:
2.2		 5x7pB-2zkmX:
19.70