SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2Z0A_A_GLYA73_0 (NONSTRUCTURAL PROTEIN 1)	2zko	NON-STRUCTURAL PROTEIN 1 (Influenza A virus)	4 / 5	GLN A 10 ALA A 60 GLN A 63 ILE A 64	None	0.55A	2z0aA-2zkoA: 14.1	2z0aA-2zkoA: 89.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2Z0A_A_GLYA74_0 (NONSTRUCTURAL PROTEIN 1)	2zko	NON-STRUCTURAL PROTEIN 1 (Influenza A virus)	4 / 4	LYS A 20 LEU A 36 ARG A 37 GLN A 40	None	1.14A	2z0aA-2zkoA: 14.1	2z0aA-2zkoA: 89.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2Z0A_C_GLYC73_0 (NONSTRUCTURAL PROTEIN 1)	2zko	NON-STRUCTURAL PROTEIN 1 (Influenza A virus)	4 / 4	ASP A 12 ASP A 39 SER A 42 ARG A 46	GOL A 71 ( 3.8A) GOL A 71 (-3.5A) GOL A 71 (-2.4A) GOL A 71 (-3.8A)	0.20A	2z0aC-2zkoA: 14.2	2z0aC-2zkoA: 89.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_D_MTXD164_2 (DIHYDROFOLATE REDUCTASE)	2zko	NON-STRUCTURAL PROTEIN 1 (Influenza A virus)	3 / 3	ARG A 19 ILE A 54 THR A 49	GOL A 71 (-3.9A) None C D 4 ( 3.4A)	0.67A	3ia4D-2zkoA: undetectable	3ia4D-2zkoA: 18.29

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Z0A_A_GLYA73_0","NONSTRUCTURAL PROTEIN 1","2zko","NON-STRUCTURAL PROTEIN 1","Influenza A virus",4,"GLN A  10;ALA A  60;GLN A  63;ILE A  64","None","0.55A","2z0aA-2zkoA:14.1","2z0aA-2zkoA:89.61"],["2Z0A_A_GLYA74_0","NONSTRUCTURAL PROTEIN 1","2zko","NON-STRUCTURAL PROTEIN 1","Influenza A virus",4,"LYS A  20;LEU A  36;ARG A  37;GLN A  40","None","1.14A","2z0aA-2zkoA:14.1","2z0aA-2zkoA:89.61"],["2Z0A_C_GLYC73_0","NONSTRUCTURAL PROTEIN 1","2zko","NON-STRUCTURAL PROTEIN 1","Influenza A virus",4,"ASP A  12;ASP A  39;SER A  42;ARG A  46","GOL A  71 ( 3.8A);GOL A  71 (-3.5A);GOL A  71 (-2.4A);GOL A  71 (-3.8A)","0.20A","2z0aC-2zkoA:14.2","2z0aC-2zkoA:89.61"],["3IA4_D_MTXD164_2","DIHYDROFOLATE REDUCTASE","2zko","NON-STRUCTURAL PROTEIN 1","Influenza A virus",3,"ARG A  19;ILE A  54;THR A  49","GOL A  71 (-3.9A);None;  C D   4 ( 3.4A)","0.67A","3ia4D-2zkoA:undetectable","3ia4D-2zkoA:18.29"]]