SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 5 ASP A 305
HIS A 309
HIS A 347
HIS A 356
ZN  A 415 (-2.3A)
ZN  A 415 (-3.5A)
ZN  A 414 (-3.5A)
ZN  A 415 (-3.5A)
0.48A 1ei6A-2zktA:
17.6
1ei6A-2zktA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 8 ASP A  13
ASP A 305
HIS A 309
HIS A 347
HIS A 356
ZN  A 414 (-2.2A)
ZN  A 415 (-2.3A)
ZN  A 415 (-3.5A)
ZN  A 414 (-3.5A)
ZN  A 415 (-3.5A)
0.53A 1ei6C-2zktA:
17.5
1ei6C-2zktA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 LEU A  12
LEU A  15
HIS A 300
LEU A   9
HIS A  64
None
1.37A 1ie9A-2zktA:
undetectable
1ie9A-2zktA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 ALA A  84
PHE A  82
GLY A  86
ALA A  97
LEU A  91
None
0.97A 1mjqC-2zktA:
undetectable
1mjqD-2zktA:
undetectable
1mjqC-2zktA:
13.40
1mjqD-2zktA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 10 ALA A  97
LEU A  91
ALA A  84
PHE A  82
GLY A  86
None
1.01A 1mjqG-2zktA:
undetectable
1mjqH-2zktA:
undetectable
1mjqG-2zktA:
13.40
1mjqH-2zktA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 ALA A  84
PHE A  82
GLY A  86
ALA A  97
LEU A  91
None
0.98A 1mjqI-2zktA:
undetectable
1mjqJ-2zktA:
undetectable
1mjqI-2zktA:
13.40
1mjqJ-2zktA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 ILE A  11
MET A 400
LEU A 363
ILE A 341
ILE A  10
None
1.02A 1rx2A-2zktA:
undetectable
1rx2A-2zktA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 10 LEU A  15
GLY A 345
LEU A  12
ILE A  10
LEU A 364
None
1.11A 2f8dB-2zktA:
undetectable
2f8dB-2zktA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
3 / 3 SER A 357
THR A 344
GLN A  49
None
0.70A 2fk8A-2zktA:
undetectable
2fk8A-2zktA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 11 GLY A 345
PHE A 298
HIS A  64
HIS A 347
ILE A  11
None
None
None
ZN  A 414 (-3.5A)
None
1.41A 2y7kA-2zktA:
undetectable
2y7kA-2zktA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 9 GLY A 367
ILE A 399
PHE A  68
PHE A 238
PHE A 296
None
1.46A 3ko0A-2zktA:
undetectable
3ko0C-2zktA:
undetectable
3ko0A-2zktA:
12.71
3ko0C-2zktA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 10 GLY A   7
PHE A 296
GLY A 367
ILE A 399
PHE A 238
None
1.40A 3ko0L-2zktA:
undetectable
3ko0N-2zktA:
undetectable
3ko0L-2zktA:
12.71
3ko0N-2zktA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 8 GLY A 367
PHE A 238
GLY A   7
PHE A 296
None
0.86A 3ko0O-2zktA:
undetectable
3ko0Q-2zktA:
undetectable
3ko0O-2zktA:
12.71
3ko0Q-2zktA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 8 GLY A 368
PHE A 238
GLY A   7
PHE A 296
None
0.96A 3ko0O-2zktA:
undetectable
3ko0Q-2zktA:
undetectable
3ko0O-2zktA:
12.71
3ko0Q-2zktA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 6 ASN A 355
HIS A 309
PRO A 350
ASP A  13
None
ZN  A 415 (-3.5A)
None
ZN  A 414 (-2.2A)
0.91A 3oi8A-2zktA:
undetectable
3oi8A-2zktA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 6 ASN A 355
HIS A 309
PRO A 350
ASP A 346
None
ZN  A 415 (-3.5A)
None
ZN  A 414 (-2.8A)
1.07A 3oi8A-2zktA:
undetectable
3oi8A-2zktA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 5 VAL A  87
ILE A 250
PHE A 298
PHE A  68
None
1.09A 3owxB-2zktA:
1.9
3owxB-2zktA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 ILE A  11
MET A 400
LEU A 363
ILE A 341
ILE A  10
None
1.06A 3ql3A-2zktA:
undetectable
3ql3A-2zktA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 6 TYR A 231
PHE A  81
PRO A 232
LEU A  85
None
1.29A 3tgvB-2zktA:
undetectable
3tgvB-2zktA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 6 TYR A 231
PHE A  81
PRO A 232
LEU A  85
None
1.19A 3tgvD-2zktA:
undetectable
3tgvD-2zktA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 6 ASP A 359
GLY A  16
ASP A  17
THR A  27
None
1.13A 3vqrA-2zktA:
undetectable
3vqrA-2zktA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 5 ASP A 359
GLY A  16
ASP A  17
THR A  27
None
1.14A 3vqrB-2zktA:
undetectable
3vqrB-2zktA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 LEU A  12
ALA A 259
PHE A  68
MET A 400
LEU A 388
None
1.39A 4iaqA-2zktA:
undetectable
4iaqA-2zktA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 7 ILE A 234
THR A  75
PHE A  82
ASP A  90
None
1.09A 4iarA-2zktA:
undetectable
4iarA-2zktA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 10 ILE A  45
ALA A  41
LEU A   9
ILE A 365
THR A 375
None
1.17A 4km0A-2zktA:
2.8
4km0A-2zktA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 9 VAL A 262
ALA A 261
GLY A 248
PHE A 264
GLY A 257
None
1.35A 4mmbA-2zktA:
undetectable
4mmbA-2zktA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 5 PHE A 298
PHE A 264
LEU A  85
PRO A 232
None
1.30A 4o8zA-2zktA:
undetectable
4o8zA-2zktA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 THR A 344
ILE A 396
GLN A  49
ILE A  11
PHE A 298
None
1.24A 4rp8C-2zktA:
undetectable
4rp8C-2zktA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 11 LEU A 331
PHE A 378
LEU A   9
LEU A 336
ALA A 366
None
1.00A 4wnuA-2zktA:
undetectable
4wnuA-2zktA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 5 GLY A 227
ARG A  79
GLY A  80
GLU A  83
None
1.15A 4z2eB-2zktA:
undetectable
4z2eC-2zktA:
undetectable
4z2eB-2zktA:
22.99
4z2eC-2zktA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 8 ALA A  97
VAL A 163
GLY A 229
ALA A 228
GLY A 227
None
1.44A 4zjzB-2zktA:
undetectable
4zjzB-2zktA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 8 LEU A 403
ILE A 341
GLY A  44
LEU A 388
None
0.72A 5eseA-2zktA:
undetectable
5eseA-2zktA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
4 / 6 ASP A  13
GLY A  14
ASP A 346
LYS A 302
ZN  A 414 (-2.2A)
None
ZN  A 414 (-2.8A)
ZN  A 415 ( 4.5A)
1.18A 5hp1C-2zktA:
undetectable
5hp1C-2zktA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 ALA A 251
PHE A 301
VAL A 255
LEU A 315
LEU A 319
None
1.46A 5x23A-2zktA:
undetectable
5x23A-2zktA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 HIS A 347
LEU A 254
HIS A  64
ASP A  13
ASP A 305
ZN  A 414 (-3.5A)
None
None
ZN  A 414 (-2.2A)
ZN  A 415 (-2.3A)
1.21A 6n91A-2zktA:
undetectable
6n91A-2zktA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii)
5 / 12 HIS A 347
LEU A 254
HIS A  64
ASP A  13
ASP A 305
ZN  A 414 (-3.5A)
None
None
ZN  A 414 (-2.2A)
ZN  A 415 (-2.3A)
1.22A 6n91B-2zktA:
undetectable
6n91B-2zktA:
11.65