SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 PHE A 421
LEU A 437
LEU A 233
LEU A 459
 None
 1.00A 2bfpC-2zl5A:
undetectable		 2bfpC-2zl5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 LEU A 272
ARG A 269
PRO A 412
VAL A 409
 None
 1.20A 2qd2A-2zl5A:
undetectable		 2qd2A-2zl5A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		6 / 12 PRO A 317
ILE A 299
LEU A 301
ASN A 267
ILE A 330
THR A 341
 None
 1.40A 3a50D-2zl5A:
undetectable		 3a50D-2zl5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 ILE A 299
LEU A 301
ASN A 267
ILE A 330
THR A 341
 None
 1.14A 3a51C-2zl5A:
undetectable		 3a51C-2zl5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 GLY A 296
GLY A 367
GLY A 365
 None
 0.41A 3bogC-2zl5A:
undetectable		 3bogC-2zl5A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 ILE A 392
PRO A 393
HIS A 404
GLY A 278
 None
ACT  A 521 (-4.6A)
None
None
 0.92A 3em0B-2zl5A:
undetectable		 3em0B-2zl5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 7 LEU A 238
VAL A 277
ILE A 442
MET A 422
 None
 1.29A 3ik3A-2zl5A:
undetectable		 3ik3A-2zl5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 7 LEU A 238
VAL A 277
ILE A 442
MET A 422
 None
 1.32A 3ik3B-2zl5A:
undetectable		 3ik3B-2zl5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 6 PHE A 352
PHE A 320
THR A 347
VAL A 345
 None
None
ACT  A 521 ( 4.5A)
None
 1.23A 3lb3A-2zl5A:
undetectable		 3lb3A-2zl5A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 6 PHE A 352
PHE A 320
THR A 347
VAL A 345
 None
None
ACT  A 521 ( 4.5A)
None
 1.25A 3lb3B-2zl5A:
undetectable		 3lb3B-2zl5A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		5 / 10 ILE A 290
TYR A 343
ILE A 299
ARG A 291
MET A 332
 None
 1.38A 3ohtA-2zl5A:
undetectable
3ohtB-2zl5A:
undetectable		 3ohtA-2zl5A:
20.97
3ohtB-2zl5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 7 ILE A 330
LEU A 373
LYS A 391
GLY A 324
 None
None
ACT  A 521 (-2.9A)
ACT  A 521 (-3.4A)
 1.06A 4hc3A-2zl5A:
undetectable		 4hc3A-2zl5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 7 LEU A 272
ARG A 269
PRO A 412
VAL A 409
 None
 1.03A 4klrA-2zl5A:
undetectable		 4klrA-2zl5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		5 / 11 GLY A 325
GLY A 324
ILE A 376
GLY A 384
GLN A 386
 ACT  A 521 (-3.3A)
ACT  A 521 (-3.4A)
None
None
None
 1.15A 4qoiA-2zl5A:
undetectable
4qoiB-2zl5A:
undetectable		 4qoiA-2zl5A:
20.54
4qoiB-2zl5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		4 / 6 VAL A 345
HIS A 329
CYH A 326
LEU A 373
 None
 1.35A 5hrqH-2zl5A:
undetectable
5hrqK-2zl5A:
undetectable
5hrqL-2zl5A:
undetectable		 5hrqH-2zl5A:
9.45
5hrqK-2zl5A:
6.44
5hrqL-2zl5A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2zl5 58 KD CAPSID PROTEIN
(Norwalk
virus) 		5 / 10 LEU A 304
ASP A 305
ILE A 359
PRO A 354
GLY A 357
 ACT  A 520 ( 4.0A)
None
None
None
None
 1.31A 6dm0B-2zl5A:
undetectable
6dm0C-2zl5A:
undetectable		 6dm0B-2zl5A:
15.16
6dm0C-2zl5A:
15.16