SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 9 THR A 127
LEU A 169
ILE A 160
ASP A 157
ILE A 193
 None
 1.10A 1gebA-2zleA:
undetectable		 1gebA-2zleA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 6 ASP A 355
LEU A 351
GLY A 350
ILE A 393
 None
 0.79A 1mt1G-2zleA:
undetectable
1mt1J-2zleA:
undetectable		 1mt1G-2zleA:
9.53
1mt1J-2zleA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 7 ILE A 393
ASP A 355
LEU A 351
GLY A 350
 None
 0.80A 1mt1H-2zleA:
undetectable
1mt1K-2zleA:
undetectable		 1mt1H-2zleA:
13.17
1mt1K-2zleA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 8 ASP A 355
LEU A 351
GLY A 350
ILE A 393
 None
 0.85A 1n13A-2zleA:
undetectable
1n13F-2zleA:
undetectable		 1n13A-2zleA:
9.53
1n13F-2zleA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 GLU A 138
GLY A 167
GLY A 131
ILE A 160
ILE A 179
 None
 1.02A 1x1aA-2zleA:
undetectable		 1x1aA-2zleA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 MET A 286
LEU A 292
ILE A 222
SER A 312
SER A 252
 None
 1.46A 1xotB-2zleA:
undetectable		 1xotB-2zleA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 7 ILE A 393
ASP A 355
LEU A 351
GLY A 350
 None
 0.83A 2qqcD-2zleA:
undetectable
2qqcE-2zleA:
undetectable		 2qqcD-2zleA:
13.17
2qqcE-2zleA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 8 ILE A 393
ASP A 355
LEU A 351
GLY A 350
 None
 0.85A 2qqcH-2zleA:
undetectable
2qqcK-2zleA:
undetectable		 2qqcH-2zleA:
13.17
2qqcK-2zleA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 11 ALA A 116
GLU A 175
VAL A 202
GLY A 174
VAL A  64
 None
 1.24A 2uxpB-2zleA:
undetectable		 2uxpB-2zleA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 11 ALA A 116
GLU A 175
VAL A 202
ILE A 113
VAL A  64
 None
 1.16A 2uxpB-2zleA:
undetectable		 2uxpB-2zleA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 ILE A 130
GLY A 166
ALA A 168
LEU A 169
ILE A 183
 None
 1.00A 3mb5A-2zleA:
undetectable		 3mb5A-2zleA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 10 ILE A 154
ALA A 196
LEU A 176
THR A 111
ILE A  19
 None
 1.11A 3prsA-2zleA:
undetectable		 3prsA-2zleA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 9 GLY A 258
ALA A 257
GLY A 221
ILE A 222
VAL A 305
 None
 0.90A 3u7sB-2zleA:
undetectable		 3u7sB-2zleA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 VAL A 145
ASN A 152
ASN A 180
LEU A 169
ILE A 177
 None
 1.47A 4kukA-2zleA:
undetectable		 4kukA-2zleA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 ASN A  66
ILE A  99
GLY A 167
ALA A 168
VAL A 202
 None
 1.12A 4nkvA-2zleA:
undetectable		 4nkvA-2zleA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 ASN A  66
ILE A  99
GLY A 167
ALA A 168
VAL A 202
 None
 1.16A 4nkvC-2zleA:
undetectable		 4nkvC-2zleA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 ASN A  66
ILE A  99
GLY A 167
ALA A 168
VAL A 202
 None
 1.15A 4nkvD-2zleA:
undetectable		 4nkvD-2zleA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 ILE A 197
GLY A 167
ALA A 168
ILE A  56
VAL A 202
 None
 0.95A 4nkxB-2zleA:
undetectable		 4nkxB-2zleA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 7 LEU A 169
ILE A  56
ILE A 113
VAL A  54
 None
 0.85A 4ojbA-2zleA:
undetectable		 4ojbA-2zleA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 9 ALA A 129
SER A 118
GLY A 178
ALA A 196
VAL A 145
 None
 1.25A 4r1zA-2zleA:
undetectable		 4r1zA-2zleA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2zle PROTEASE DO
(Escherichia
coli) 		3 / 3 MET A  90
GLN A 208
TYR A 212
 None
 0.99A 4udcA-2zleA:
undetectable		 4udcA-2zleA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2zle PROTEASE DO
(Escherichia
coli) 		4 / 7 LEU A 292
LEU A 294
GLU A 308
LEU A 220
 None
 0.76A 4wg0L-2zleA:
undetectable
4wg0M-2zleA:
undetectable		 4wg0L-2zleA:
3.13
4wg0M-2zleA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 2zle PROTEASE DO
(Escherichia
coli) 		3 / 3 ASN A 324
SER A 320
SER A 319
 None
 0.67A 5gsnA-2zleA:
undetectable		 5gsnA-2zleA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 LEU A  50
ALA A  49
VAL A  21
ILE A 179
ALA A 168
 None
 1.05A 5n5dB-2zleA:
undetectable		 5n5dB-2zleA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2zle PROTEASE DO
(Escherichia
coli) 		5 / 12 ILE A 104
ILE A 102
ALA A 100
ILE A 179
ALA A 168
 None
 1.13A 5vceA-2zleA:
undetectable		 5vceA-2zleA:
21.05