SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 8 THR A 108
ASP A  42
MET A 109
LEU A 286
 A  C  37 ( 2.9A)
A  C  37 ( 2.8A)
None
None
 1.07A 1lhvA-2zm5A:
undetectable		 1lhvA-2zm5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 6 ARG A 213
ALA A  20
ILE A 283
PRO A  18
 None
 1.15A 1oniH-2zm5A:
undetectable
1oniI-2zm5A:
undetectable		 1oniH-2zm5A:
22.18
1oniI-2zm5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 104
LEU A 103
ILE A 314
TYR A 195
 None
 1.15A 2hc4A-2zm5A:
undetectable		 2hc4A-2zm5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 5 GLN A 253
ALA A 274
GLN A 277
ARG A 281
 None
None
A  C  26 ( 3.4A)
A  C  38 ( 3.7A)
 1.31A 2z0aA-2zm5A:
undetectable		 2z0aA-2zm5A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 8 THR A 181
LEU A 172
ALA A 157
ALA A 156
 None
 0.98A 3ns1L-2zm5A:
undetectable		 3ns1L-2zm5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 7 LEU A 209
ALA A  20
GLY A  17
ILE A 202
 None
 0.85A 3spkB-2zm5A:
undetectable		 3spkB-2zm5A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 8 PRO A 204
GLN A 282
GLN A 220
ILE A 214
 None
 1.08A 4iilA-2zm5A:
undetectable		 4iilA-2zm5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  17
GLY A 106
ILE A 283
SER A  21
LEU A 210
 None
 1.00A 4iv0A-2zm5A:
2.8		 4iv0A-2zm5A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 106
 None
 1.04A 4j7xA-2zm5A:
3.2		 4j7xA-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 107
 None
 1.09A 4j7xA-2zm5A:
3.2		 4j7xA-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 106
 None
 1.06A 4j7xB-2zm5A:
3.3		 4j7xB-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 107
 None
 1.08A 4j7xB-2zm5A:
3.3		 4j7xB-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 106
 None
 1.03A 4j7xF-2zm5A:
3.1		 4j7xF-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 LEU A 115
PHE A  14
TRP A 289
MET A  16
GLY A 107
 None
 1.06A 4j7xF-2zm5A:
3.1		 4j7xF-2zm5A:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		3 / 3 LEU A 210
ILE A 214
ARG A 217
 None
 0.63A 4mk4B-2zm5A:
2.5		 4mk4B-2zm5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  17
GLY A 106
ILE A 283
SER A  21
LEU A 210
 None
 0.96A 4mwzA-2zm5A:
2.8		 4mwzA-2zm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 12 GLY A  17
GLY A 106
ILE A 283
SER A  21
LEU A 210
 None
 1.01A 4mwzB-2zm5A:
2.7		 4mwzB-2zm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 5 VAL A 268
TYR A  47
ILE A  72
THR A 108
 None
None
None
A  C  37 ( 2.9A)
 1.03A 4ze1A-2zm5A:
undetectable		 4ze1A-2zm5A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		5 / 10 GLU A  61
LEU A 286
THR A 108
PRO A  57
LEU A  45
 None
None
A  C  37 ( 2.9A)
None
A  C  37 ( 4.6A)
 1.44A 5mm4B-2zm5A:
undetectable		 5mm4B-2zm5A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE
(Escherichia
coli) 		4 / 6 GLN A 140
GLU A 143
ALA A 137
GLN A 136
 None
 1.28A 6f6jC-2zm5A:
undetectable
6f6jD-2zm5A:
undetectable		 6f6jC-2zm5A:
24.81
6f6jD-2zm5A:
24.81