SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 10 ALA A 551
ILE A 586
ASP A 608
LEU A 654
ILE A 663
 None
None
None
None
7PE  A   1 (-4.7A)
 0.98A 1yi4A-2zmcA:
23.2		 1yi4A-2zmcA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 5 LEU A 764
THR A 728
HIS A 788
LEU A 785
 None
 0.87A 3ce6D-2zmcA:
undetectable		 3ce6D-2zmcA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 6 VAL A 539
LYS A 553
LEU A 654
ASP A 664
 None
7PE  A   1 (-2.6A)
None
None
 0.78A 3cs9D-2zmcA:
21.7		 3cs9D-2zmcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 12 THR A 637
ILE A 643
GLY A 642
HIS A 641
LEU A 662
 None
 1.17A 3eeyD-2zmcA:
undetectable		 3eeyD-2zmcA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 12 GLU A 545
TYR A 589
VAL A 601
TYR A 525
VAL A 520
 None
 1.42A 3g0bB-2zmcA:
3.0		 3g0bB-2zmcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 12 GLU A 545
TYR A 589
VAL A 601
TYR A 525
VAL A 520
 None
 1.41A 3g0bC-2zmcA:
3.0		 3g0bC-2zmcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 12 GLU A 545
TYR A 589
VAL A 601
TYR A 525
VAL A 520
 None
 1.40A 3g0bD-2zmcA:
3.4		 3g0bD-2zmcA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 GLY A 532
VAL A 539
ALA A 551
LYS A 553
ILE A 586
LEU A 654
 None
None
None
7PE  A   1 (-2.6A)
None
None
 1.07A 3ohtA-2zmcA:
6.5		 3ohtA-2zmcA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 GLY A 532
VAL A 539
ALA A 551
LYS A 553
LEU A 575
ILE A 586
 None
None
None
7PE  A   1 (-2.6A)
None
None
 0.78A 3ohtA-2zmcA:
6.5		 3ohtA-2zmcA:
28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 8 VAL A 539
LYS A 553
ILE A 586
ILE A 663
 None
7PE  A   1 (-2.6A)
None
7PE  A   1 (-4.7A)
 0.65A 3warA-2zmcA:
21.1		 3warA-2zmcA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 None
None
None
7PE  A   1 (-3.4A)
None
None
 0.79A 4bkjA-2zmcA:
22.7		 4bkjA-2zmcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 12 VAL A 539
ALA A 551
ILE A 586
MET A 600
LEU A 654
ASP A 664
 None
None
None
7PE  A   1 (-3.4A)
None
None
 0.70A 4bkjB-2zmcA:
22.7		 4bkjB-2zmcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIX_A_NIMA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 4 LEU A 648
ALA A 634
ILE A 638
LYS A 649
 None
 1.39A 4eixA-2zmcA:
undetectable		 4eixA-2zmcA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 11 VAL A 539
ALA A 551
LYS A 553
ASP A 608
LEU A 654
ILE A 663
 None
None
7PE  A   1 (-2.6A)
None
None
7PE  A   1 (-4.7A)
 0.76A 4iaaA-2zmcA:
22.9		 4iaaA-2zmcA:
26.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 8 ALA A 668
GLU A 571
ILE A 572
ILE A 593
 7PE  A   1 ( 4.0A)
7PE  A   1 (-3.7A)
None
None
 0.91A 4kttB-2zmcA:
undetectable		 4kttB-2zmcA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 7 VAL A 539
ALA A 551
MET A 602
ASP A 608
LEU A 654
 None
None
7PE  A   1 ( 4.3A)
None
None
 0.96A 4l9iA-2zmcA:
8.7		 4l9iA-2zmcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		6 / 8 GLY A 534
VAL A 539
ALA A 551
LYS A 553
MET A 602
ASP A 608
 None
None
None
7PE  A   1 (-2.6A)
7PE  A   1 ( 4.3A)
None
 0.79A 4l9iB-2zmcA:
21.9		 4l9iB-2zmcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 8 VAL A 539
ALA A 551
MET A 602
ASP A 608
LEU A 654
 None
None
7PE  A   1 ( 4.3A)
None
None
 1.04A 4l9iB-2zmcA:
21.9		 4l9iB-2zmcA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		5 / 10 GLY A 532
VAL A 539
ALA A 551
ILE A 586
MET A 602
 None
None
None
None
7PE  A   1 ( 4.3A)
 0.82A 5lw1E-2zmcA:
23.0		 5lw1E-2zmcA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 2zmc DUAL SPECIFICITY
PROTEIN KINASE TTK
(Homo
sapiens) 		4 / 7 VAL A 539
LYS A 553
ILE A 586
ILE A 663
 None
7PE  A   1 (-2.6A)
None
7PE  A   1 (-4.7A)
 0.59A 5ywmX-2zmcA:
21.0		 5ywmX-2zmcA:
13.05