SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zmf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		3 / 3 TYR A 362
VAL A 385
THR A 363
 CMP  A2001 ( 4.3A)
None
None
 0.75A 2ygnA-2zmfA:
undetectable		 2ygnA-2zmfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		5 / 12 ASN A 342
VAL A 385
ALA A 278
ILE A 343
THR A 364
 None
None
None
None
CMP  A2001 (-2.8A)
 1.24A 3dl9B-2zmfA:
undetectable		 3dl9B-2zmfA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		5 / 12 LEU A 289
ILE A 372
CYH A 408
LEU A 271
PHE A 401
 None
 1.15A 3ko0K-2zmfA:
undetectable
3ko0L-2zmfA:
undetectable
3ko0S-2zmfA:
undetectable
3ko0T-2zmfA:
undetectable		 3ko0K-2zmfA:
17.86
3ko0L-2zmfA:
17.86
3ko0S-2zmfA:
17.86
3ko0T-2zmfA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		5 / 12 LEU A 271
LEU A 289
ILE A 372
CYH A 408
PHE A 401
 None
 1.15A 3ko0K-2zmfA:
undetectable
3ko0L-2zmfA:
undetectable
3ko0M-2zmfA:
undetectable
3ko0N-2zmfA:
undetectable		 3ko0K-2zmfA:
17.86
3ko0L-2zmfA:
17.86
3ko0M-2zmfA:
17.86
3ko0N-2zmfA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2zmf CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens) 		3 / 3 ASN A 366
ALA A 392
LYS A 387
 None
 0.77A 3runA-2zmfA:
undetectable		 3runA-2zmfA:
18.62