SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 10 LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
 None
 1.16A 1fkoA-2znsA:
undetectable		 1fkoA-2znsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 6 TYR A 718
VAL A 730
ILE A 727
LEU A 659
 None
 0.97A 1j96A-2znsA:
undetectable		 1j96A-2znsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 7 TYR A 718
VAL A 730
ILE A 727
LEU A 659
 None
 0.93A 1j96B-2znsA:
undetectable		 1j96B-2znsA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_A_CYZA330_1
(GLUTAMINE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 12 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.81A 1lbcA-2znsA:
37.7
1lbcC-2znsA:
37.9		 1lbcA-2znsA:
52.87
1lbcC-2znsA:
52.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_B_CYZB329_1
(GLUTAMINE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 9 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.90A 1lbcB-2znsA:
37.8		 1lbcB-2znsA:
52.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LBC_C_CYZC331_1
(GLUTAMINE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 12 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.84A 1lbcA-2znsA:
37.7
1lbcC-2znsA:
37.9		 1lbcA-2znsA:
52.87
1lbcC-2znsA:
52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 11 LEU A 770
ILE A 767
VAL A 751
GLY A 750
LEU A 456
 None
 1.20A 2bxeA-2znsA:
undetectable		 2bxeA-2znsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 LEU A 770
ILE A 767
VAL A 751
GLY A 750
LEU A 456
 None
 1.19A 2bxeB-2znsA:
undetectable		 2bxeB-2znsA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 6 GLY A 475
GLY A 673
MET A 676
ASN A 484
 None
GLU  A 301 (-3.2A)
None
None
 1.00A 3e9rA-2znsA:
undetectable		 3e9rA-2znsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 6 GLY A 475
GLY A 673
MET A 676
ASN A 484
 None
GLU  A 301 (-3.2A)
None
None
 0.99A 3e9rC-2znsA:
undetectable		 3e9rC-2znsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 LEU A 460
LEU A 452
LEU A 453
LEU A 497
LEU A 770
 None
 1.11A 3erdA-2znsA:
undetectable		 3erdA-2znsA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_A_CYZA265_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 11 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.84A 3h6tA-2znsA:
37.2
3h6tC-2znsA:
37.4		 3h6tA-2znsA:
52.87
3h6tC-2znsA:
52.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_B_CYZB265_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 9 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.84A 3h6tB-2znsA:
37.5		 3h6tB-2znsA:
52.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H6T_C_CYZC265_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 11 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.76A 3h6tA-2znsA:
37.2
3h6tC-2znsA:
37.3		 3h6tA-2znsA:
52.87
3h6tC-2znsA:
52.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 LEU A 460
LEU A 452
LEU A 453
LEU A 497
LEU A 770
 None
 1.12A 3hm1A-2znsA:
undetectable		 3hm1A-2znsA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 12 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.90A 3iltB-2znsA:
35.4
3iltE-2znsA:
35.4		 3iltB-2znsA:
51.92
3iltE-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 10 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.82A 3iltB-2znsA:
35.4
3iltE-2znsA:
35.4		 3iltB-2znsA:
51.92
3iltE-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 11 ILE A 504
PRO A 517
SER A 746
LYS A 747
GLY A 748
 None
 0.64A 3iluB-2znsA:
37.5
3iluE-2znsA:
37.9		 3iluB-2znsA:
51.92
3iluE-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 8 TYR A 448
PRO A 517
MET A 519
LEU A 776
LYS A 780
 None
 0.33A 3lsfH-2znsA:
37.4		 3lsfH-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 7 TYR A 448
MET A 519
LEU A 776
LYS A 780
 None
 0.45A 3lslA-2znsA:
37.3
3lslD-2znsA:
36.9		 3lslA-2znsA:
51.92
3lslD-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 8 ILE A 504
PRO A 517
SER A 746
GLY A 748
 None
 0.25A 3lslA-2znsA:
37.4
3lslD-2znsA:
37.0		 3lslA-2znsA:
51.92
3lslD-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 7 TYR A 448
MET A 519
LEU A 776
LYS A 780
 None
 0.43A 3lslA-2znsA:
37.3
3lslD-2znsA:
36.9		 3lslA-2znsA:
51.92
3lslD-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 8 ILE A 504
PRO A 517
SER A 746
GLY A 748
 None
 0.23A 3lslA-2znsA:
37.4
3lslD-2znsA:
37.0		 3lslA-2znsA:
51.92
3lslD-2znsA:
51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 6 TYR A 448
MET A 519
LEU A 776
LYS A 780
 None
 0.40A 3lslG-2znsA:
36.9		 3lslG-2znsA:
51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
 None
 1.09A 3mecA-2znsA:
undetectable		 3mecA-2znsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		3 / 3 GLY A 475
GLY A 673
THR A 677
 None
GLU  A 301 (-3.2A)
None
 0.41A 3si7B-2znsA:
undetectable		 3si7B-2znsA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 9 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.81A 3tkdA-2znsA:
19.7		 3tkdA-2znsA:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 5 ILE A 504
PRO A 517
LYS A 747
GLY A 748
 None
 0.18A 3tkdB-2znsA:
37.7		 3tkdB-2znsA:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 5 ILE A 504
PRO A 517
LYS A 747
GLY A 748
 None
 0.17A 3tkdA-2znsA:
19.7		 3tkdA-2znsA:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 5 PRO A 517
SER A 746
LYS A 747
GLY A 748
 None
 0.67A 3tkdA-2znsA:
19.7		 3tkdA-2znsA:
53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		6 / 9 LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.81A 3tkdB-2znsA:
37.7		 3tkdB-2znsA:
53.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 LEU A 721
GLY A 742
ILE A 523
ILE A 727
ASP A 654
 None
 0.91A 3uj6A-2znsA:
undetectable		 3uj6A-2znsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		3 / 3 VAL A 751
ALA A 500
PHE A 518
 None
 0.92A 4w5nA-2znsA:
undetectable		 4w5nA-2znsA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 TYR A 464
THR A 418
LEU A 460
ILE A 420
THR A 764
 None
 1.18A 5ewjC-2znsA:
undetectable
5ewjD-2znsA:
undetectable		 5ewjC-2znsA:
20.39
5ewjD-2znsA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		4 / 8 SER A 674
THR A 503
THR A 505
ILE A 523
 GLU  A 301 (-3.2A)
GLU  A 301 (-3.9A)
None
None
 0.92A 5jhdE-2znsA:
undetectable
5jhdG-2znsA:
undetectable		 5jhdE-2znsA:
20.30
5jhdG-2znsA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		3 / 3 GLU A 728
TYR A 729
ARG A 733
 None
 0.75A 5uunA-2znsA:
undetectable		 5uunA-2znsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 12 GLN A 739
SER A 524
GLU A 723
LEU A 743
PHE A 678
 None
None
GLU  A 301 ( 2.8A)
None
None
 1.50A 5vlmA-2znsA:
undetectable		 5vlmA-2znsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 10 LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
 None
 1.11A 6bsgA-2znsA:
undetectable		 6bsgA-2znsA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 11 PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.85A 6dlzA-2znsA:
32.3
6dlzD-2znsA:
31.6		 6dlzA-2znsA:
14.51
6dlzD-2znsA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens) 		5 / 11 PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
 None
 0.84A 6dm1A-2znsA:
32.3
6dm1D-2znsA:
31.6		 6dm1A-2znsA:
14.51
6dm1D-2znsA:
14.51