SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2znw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		4 / 7 ASP A  82
SER A  18
SER A  74
ASN A  76
 None
 1.15A 1ig3A-2znwA:
undetectable
1ig3B-2znwA:
undetectable		 1ig3A-2znwA:
21.23
1ig3B-2znwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		4 / 8 LEU A  33
ALA A  25
ILE A   2
GLY A  99
 None
 0.85A 1sv9A-2znwA:
undetectable		 1sv9A-2znwA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		4 / 6 SER A 184
TYR A 169
GLN A   6
ASP A   1
 None
 1.37A 2cl5B-2znwA:
undetectable		 2cl5B-2znwA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		4 / 7 GLY A 171
GLY A 222
GLN A  89
PHE A  98
 None
1PG  A 243 ( 4.7A)
1PG  A 243 (-3.2A)
None
 0.92A 2qwxA-2znwA:
undetectable
2qwxB-2znwA:
undetectable		 2qwxA-2znwA:
20.61
2qwxB-2znwA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		4 / 6 SER A 184
TYR A 169
GLN A   6
ASP A   1
 None
 1.38A 2zvjA-2znwA:
undetectable		 2zvjA-2znwA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2znw SCFV10
(Mus
musculus;
synthetic
construct) 		3 / 3 TYR A  36
TYR A 169
GLY A 222
 None
None
1PG  A 243 ( 4.7A)
 0.71A 3eteB-2znwA:
undetectable
3eteD-2znwA:
undetectable
3eteF-2znwA:
undetectable		 3eteB-2znwA:
18.74
3eteD-2znwA:
18.74
3eteF-2znwA:
18.74