SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 220
GLY A 153
ASP A 152
 None
 0.59A 1kf6A-2zo4A:
undetectable
1kf6B-2zo4A:
undetectable		 1kf6A-2zo4A:
22.54
1kf6B-2zo4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 ASP A  74
GLY A  77
ILE A  66
PHE A  82
ALA A  34
 ZN  A 319 (-2.8A)
None
None
None
None
 1.31A 1oltA-2zo4A:
undetectable		 1oltA-2zo4A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 11 ASP A  74
HIS A  75
HIS A 171
ASP A 190
HIS A 233
 ZN  A 319 (-2.8A)
ZN  A 319 (-3.2A)
ZN  A 318 (-3.3A)
ZN  A 319 ( 2.4A)
ZN  A 319 (-3.3A)
 0.52A 2q0jB-2zo4A:
21.9		 2q0jB-2zo4A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 171
HIS A  70
HIS A 175
 ZN  A 318 (-3.3A)
ZN  A 318 (-3.4A)
None
 0.74A 3ag4A-2zo4A:
undetectable		 3ag4A-2zo4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 HIS A 175
GLU A  95
HIS A  71
 None
 0.72A 3ba0A-2zo4A:
undetectable		 3ba0A-2zo4A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 ASN A 199
THR A 292
PHE A 276
VAL A 196
LEU A 193
 None
 1.42A 3elzC-2zo4A:
undetectable		 3elzC-2zo4A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A  45
LEU A  40
VAL A  63
ILE A  66
LEU A  24
 None
 0.94A 3h0aA-2zo4A:
undetectable		 3h0aA-2zo4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 172
GLY A 174
GLY A  99
ALA A 191
HIS A  75
 None
None
None
None
ZN  A 319 (-3.2A)
 1.15A 3ou6B-2zo4A:
undetectable		 3ou6B-2zo4A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 172
GLY A 174
GLY A  99
ALA A 191
HIS A  75
 None
None
None
None
ZN  A 319 (-3.2A)
 1.16A 3ou7B-2zo4A:
undetectable		 3ou7B-2zo4A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 6 GLU A  95
PRO A 210
ARG A  98
GLY A 174
 None
 1.43A 3oxvA-2zo4A:
undetectable		 3oxvA-2zo4A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 309
PRO A 311
GLY A 121
THR A 122
 None
 0.80A 3tajA-2zo4A:
undetectable		 3tajA-2zo4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 137
VAL A 141
HIS A  70
ASP A 190
ASP A  74
 None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
ZN  A 319 (-2.8A)
 1.41A 3ximA-2zo4A:
undetectable		 3ximA-2zo4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_B_SORB397_0
(D-XYLOSE ISOMERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 137
VAL A 141
HIS A  70
ASP A 190
ASP A  74
 None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
ZN  A 319 (-2.8A)
 1.46A 3ximB-2zo4A:
undetectable		 3ximB-2zo4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_C_SORC397_0
(D-XYLOSE ISOMERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 137
VAL A 141
HIS A  70
ASP A 190
ASP A  74
 None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
ZN  A 319 (-2.8A)
 1.41A 3ximC-2zo4A:
undetectable		 3ximC-2zo4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 137
VAL A 141
HIS A  70
ASP A 190
ASP A  74
 None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
ZN  A 319 (-2.8A)
 1.41A 3ximD-2zo4A:
undetectable		 3ximD-2zo4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		6 / 10 HIS A  70
HIS A  72
ASP A  74
HIS A 171
ASN A 199
HIS A 233
 ZN  A 318 (-3.4A)
ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
None
ZN  A 319 (-3.3A)
 0.88A 4c1dB-2zo4A:
19.8		 4c1dB-2zo4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 11 HIS A  70
HIS A  72
ASP A  74
ASN A 199
HIS A 233
 ZN  A 318 (-3.4A)
ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
None
ZN  A 319 (-3.3A)
 0.62A 4c1fA-2zo4A:
20.2
4c1fB-2zo4A:
19.6		 4c1fA-2zo4A:
20.30
4c1fB-2zo4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 11 HIS A  70
HIS A  72
ASP A  74
HIS A 171
HIS A 233
 ZN  A 318 (-3.4A)
ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
ZN  A 319 (-3.3A)
 0.66A 4c1fA-2zo4A:
20.2
4c1fB-2zo4A:
19.6		 4c1fA-2zo4A:
20.30
4c1fB-2zo4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 9 HIS A  70
HIS A  72
ASP A  74
HIS A 171
HIS A 233
 ZN  A 318 (-3.4A)
ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
ZN  A 319 (-3.3A)
 0.62A 4c1hA-2zo4A:
21.0		 4c1hA-2zo4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 5 GLY A 189
THR A  38
VAL A  22
ASP A 190
 None
None
None
ZN  A 319 ( 2.4A)
 0.94A 4eohA-2zo4A:
undetectable		 4eohA-2zo4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  72
ASP A  74
ASN A 199
HIS A 233
 ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
None
ZN  A 319 (-3.3A)
 0.76A 4exsB-2zo4A:
18.9		 4exsB-2zo4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  72
ASP A  74
HIS A 171
HIS A 233
 ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
ZN  A 319 (-3.3A)
 0.64A 4exsB-2zo4A:
18.9		 4exsB-2zo4A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 5 TYR A 230
LEU A 192
ASP A 239
GLU A 194
 None
 1.26A 4nkvA-2zo4A:
undetectable		 4nkvA-2zo4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 PHE A 178
ARG A 162
ALA A 155
LEU A 156
 None
 0.85A 4rkuA-2zo4A:
undetectable
4rkuJ-2zo4A:
undetectable		 4rkuA-2zo4A:
17.72
4rkuJ-2zo4A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 7 PHE A 178
ARG A 162
ALA A 155
LEU A 156
 None
 0.78A 4xk8A-2zo4A:
undetectable		 4xk8A-2zo4A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  72
ASP A  74
HIS A 171
ASN A 199
 ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
None
 0.94A 5a5zA-2zo4A:
18.9		 5a5zA-2zo4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  72
ASP A  74
HIS A 171
HIS A 233
 ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
ZN  A 319 (-3.3A)
 0.69A 5a5zA-2zo4A:
18.9		 5a5zA-2zo4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		6 / 11 HIS A  70
HIS A  72
ASP A  74
HIS A  75
HIS A 171
HIS A 233
 ZN  A 318 (-3.4A)
ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 319 (-3.2A)
ZN  A 318 (-3.3A)
ZN  A 319 (-3.3A)
 0.38A 5ayaA-2zo4A:
20.0		 5ayaA-2zo4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 GLU A  95
HIS A  71
ASP A 190
 None
None
ZN  A 319 ( 2.4A)
 0.87A 5c0oG-2zo4A:
undetectable		 5c0oG-2zo4A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 191
GLY A 189
GLY A 232
LEU A 180
GLU A 181
 None
 1.07A 5c0oH-2zo4A:
undetectable		 5c0oH-2zo4A:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 8 GLU A  95
HIS A 175
GLY A 170
HIS A  70
ASP A 190
 None
None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
 1.32A 5f8yA-2zo4A:
undetectable		 5f8yA-2zo4A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 8 GLU A  95
HIS A 175
GLY A 170
HIS A  70
ASP A 190
 None
None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
 1.30A 5f8yB-2zo4A:
undetectable		 5f8yB-2zo4A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 190
HIS A 171
HIS A  70
HIS A 233
 ZN  A 319 ( 2.4A)
ZN  A 318 (-3.3A)
ZN  A 318 (-3.4A)
ZN  A 319 (-3.3A)
 0.91A 5ncdA-2zo4A:
undetectable
5ncdD-2zo4A:
undetectable		 5ncdA-2zo4A:
20.96
5ncdD-2zo4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 6 ASP A 190
HIS A 171
HIS A  70
HIS A 233
 ZN  A 319 ( 2.4A)
ZN  A 318 (-3.3A)
ZN  A 318 (-3.4A)
ZN  A 319 (-3.3A)
 0.90A 5ncdB-2zo4A:
undetectable
5ncdC-2zo4A:
undetectable		 5ncdB-2zo4A:
20.96
5ncdC-2zo4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 ASP A 190
HIS A 171
HIS A  70
HIS A 233
 ZN  A 319 ( 2.4A)
ZN  A 318 (-3.3A)
ZN  A 318 (-3.4A)
ZN  A 319 (-3.3A)
 0.87A 5nekD-2zo4A:
undetectable		 5nekD-2zo4A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 10 LEU A 192
GLY A 235
VAL A 228
LEU A 186
ALA A 188
 None
 1.18A 5o96E-2zo4A:
undetectable
5o96F-2zo4A:
undetectable		 5o96E-2zo4A:
22.73
5o96F-2zo4A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_D_SORD397_0
(D-XYLOSE ISOMERASE)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 137
VAL A 141
HIS A  70
ASP A 190
ASP A  74
 None
None
ZN  A 318 (-3.4A)
ZN  A 319 ( 2.4A)
ZN  A 319 (-2.8A)
 1.46A 5ximD-2zo4A:
undetectable		 5ximD-2zo4A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 8 HIS A  72
ASP A  74
HIS A 171
HIS A 233
 ZN  A 318 (-3.3A)
ZN  A 319 (-2.8A)
ZN  A 318 (-3.3A)
ZN  A 319 (-3.3A)
 0.70A 5zj8A-2zo4A:
19.1		 5zj8A-2zo4A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		3 / 3 ALA A 229
VAL A  36
TYR A  25
 None
 0.68A 5zmqH-2zo4A:
undetectable		 5zmqH-2zo4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN
(Thermus
thermophilus) 		4 / 5 HIS A 100
HIS A  92
LEU A 156
VAL A 165
 None
 1.15A 6bc9A-2zo4A:
undetectable		 6bc9A-2zo4A:
13.03