SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zoa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 8 ASP A   8
ASP A  50
HIS A  81
HIS A 156
ILE A 170
 FE2  A 275 ( 3.1A)
FE2  A 276 (-2.7A)
MLI  A 277 (-4.3A)
FE2  A 276 (-3.6A)
None
 1.27A 1ei6C-2zoaA:
undetectable		 1ei6C-2zoaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 12 ILE A  77
LEU A 131
SER A 121
HIS A   5
ILE A 191
 None
 1.06A 1fmlB-2zoaA:
undetectable		 1fmlB-2zoaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 7 GLY A 194
HIS A 195
THR A 200
THR A 211
 None
FE2  A 276 ( 3.5A)
None
None
 0.87A 1gtnF-2zoaA:
undetectable
1gtnG-2zoaA:
undetectable		 1gtnF-2zoaA:
13.50
1gtnG-2zoaA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 7 GLY A 194
HIS A 195
THR A 200
THR A 211
 None
FE2  A 276 ( 3.5A)
None
None
 0.90A 1gtnJ-2zoaA:
undetectable
1gtnK-2zoaA:
undetectable		 1gtnJ-2zoaA:
13.50
1gtnK-2zoaA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 12 HIS A 156
HIS A 157
GLY A 129
ASP A  50
HIS A 195
 FE2  A 276 (-3.6A)
None
None
FE2  A 276 (-2.7A)
FE2  A 276 ( 3.5A)
 1.48A 1t69A-2zoaA:
undetectable		 1t69A-2zoaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		3 / 3 HIS A 197
HIS A 217
HIS A  10
 FE2  A 275 ( 3.6A)
None
FE2  A 275 ( 3.6A)
 0.49A 2ozrF-2zoaA:
undetectable		 2ozrF-2zoaA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 8 ILE A  51
SER A 121
ASP A   8
SER A  48
 None
None
FE2  A 275 ( 3.1A)
None
 1.01A 2zw9B-2zoaA:
2.1		 2zw9B-2zoaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 4 LEU A 212
PRO A 213
LEU A 238
ARG A 190
 None
 1.22A 3hcoB-2zoaA:
2.2		 3hcoB-2zoaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		3 / 3 HIS A 156
HIS A 195
HIS A 157
 FE2  A 276 (-3.6A)
FE2  A 276 ( 3.5A)
None
 0.76A 3mihA-2zoaA:
undetectable		 3mihA-2zoaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		3 / 3 HIS A 157
HIS A 156
HIS A 195
 None
FE2  A 276 (-3.6A)
FE2  A 276 ( 3.5A)
 0.57A 3mihA-2zoaA:
undetectable		 3mihA-2zoaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 12 LEU A 162
HIS A 156
GLY A 129
SER A 121
LEU A 160
 None
FE2  A 276 (-3.6A)
None
None
None
 1.32A 3okxA-2zoaA:
undetectable		 3okxA-2zoaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 12 LEU A 162
HIS A 156
GLY A 129
SER A 121
LEU A 160
 None
FE2  A 276 (-3.6A)
None
None
None
 1.33A 3okxB-2zoaA:
undetectable		 3okxB-2zoaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 5 LEU A 238
SER A 210
LEU A 212
PRO A 213
 None
 1.31A 3onnA-2zoaA:
undetectable		 3onnA-2zoaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		3 / 3 HIS A  10
SER A  13
GLU A  59
 FE2  A 275 ( 3.6A)
None
None
 0.89A 3s8pA-2zoaA:
undetectable		 3s8pA-2zoaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 12 LEU A  76
LEU A  94
ILE A  51
VAL A  32
ARG A  14
 None
 1.22A 4f4dA-2zoaA:
undetectable		 4f4dA-2zoaA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 11 ASP A 120
HIS A 195
HIS A 157
ASP A   8
GLY A 194
 None
FE2  A 276 ( 3.5A)
None
FE2  A 275 ( 3.1A)
None
 1.27A 4lxzB-2zoaA:
undetectable		 4lxzB-2zoaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 6 ILE A   6
ILE A  66
SER A  69
LEU A  74
 None
 0.94A 4m51A-2zoaA:
2.8		 4m51A-2zoaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		6 / 12 LEU A  74
ALA A  63
THR A 215
ILE A  66
VAL A  32
VAL A  31
 None
 1.33A 4nkxB-2zoaA:
undetectable		 4nkxB-2zoaA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 12 THR A 114
VAL A  45
ALA A   4
LEU A   3
HIS A 240
 None
 1.02A 5kocA-2zoaA:
undetectable		 5kocA-2zoaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 7 ASP A 168
PRO A 169
SER A 198
ASN A 196
 None
 1.16A 5l1fC-2zoaA:
2.3		 5l1fC-2zoaA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 6 ASP A  50
ASP A   8
HIS A  10
HIS A 197
HIS A 156
 FE2  A 276 (-2.7A)
FE2  A 275 ( 3.1A)
FE2  A 275 ( 3.6A)
FE2  A 275 ( 3.6A)
FE2  A 276 (-3.6A)
 1.13A 5ncdB-2zoaA:
2.6
5ncdC-2zoaA:
undetectable		 5ncdB-2zoaA:
22.18
5ncdC-2zoaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 4 ASP A  50
HIS A 156
HIS A 195
HIS A  81
 FE2  A 276 (-2.7A)
FE2  A 276 (-3.6A)
FE2  A 276 ( 3.5A)
MLI  A 277 (-4.3A)
 1.47A 5ncdD-2zoaA:
2.4		 5ncdD-2zoaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		5 / 6 ASP A  50
ASP A   8
HIS A  10
HIS A 197
HIS A 156
 FE2  A 276 (-2.7A)
FE2  A 275 ( 3.1A)
FE2  A 275 ( 3.6A)
FE2  A 275 ( 3.6A)
FE2  A 276 (-3.6A)
 1.10A 5nelA-2zoaA:
undetectable
5nelD-2zoaA:
undetectable		 5nelA-2zoaA:
22.18
5nelD-2zoaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 6 ASP A  50
HIS A  10
HIS A 197
HIS A 156
 FE2  A 276 (-2.7A)
FE2  A 275 ( 3.6A)
FE2  A 275 ( 3.6A)
FE2  A 276 (-3.6A)
 1.04A 5nelB-2zoaA:
2.5
5nelC-2zoaA:
undetectable		 5nelB-2zoaA:
22.18
5nelC-2zoaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 6 PHE A  11
VAL A  31
LEU A  70
LEU A  67
 None
 0.92A 6e43A-2zoaA:
undetectable		 6e43A-2zoaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 6 PHE A  11
VAL A  31
LEU A  70
LEU A  67
 None
 0.89A 6e43B-2zoaA:
undetectable		 6e43B-2zoaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 6 PHE A  11
VAL A  31
LEU A  70
LEU A  67
 None
 0.95A 6e43C-2zoaA:
undetectable		 6e43C-2zoaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		4 / 6 PHE A  11
VAL A  31
LEU A  70
LEU A  67
 None
 0.95A 6e43D-2zoaA:
undetectable		 6e43D-2zoaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 2zoa PHOSPHOHYDROLASE
(Klebsiella
aerogenes) 		3 / 3 HIS A 176
ASN A 174
LEU A 131
 None
 0.83A 6f7lB-2zoaA:
undetectable		 6f7lB-2zoaA:
19.95