SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FC6_C_REAC501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	2zon	CYTOCHROME C551 (Achromobacter xylosoxidans)	5 / 12	VAL G 79 ALA G 85 ALA G 86 LEU G 34 VAL G 55	HEM G 200 ( 4.5A) None None None HEM G 200 ( 4.8A)	1.00A	3fc6C-2zonG: undetectable	3fc6C-2zonG: 17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVN_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2zon	CYTOCHROME C551 (Achromobacter xylosoxidans)	5 / 12	SER G 18 THR G 74 ALA G 78 GLY G 67 ALA G 19	None None HEM G 200 ( 3.9A) None None	1.25A	4qvnV-2zonG: undetectable 4qvnb-2zonG: undetectable	4qvnV-2zonG: 18.81 4qvnb-2zonG: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVN_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	2zon	CYTOCHROME C551 (Achromobacter xylosoxidans)	5 / 12	SER G 18 THR G 74 ALA G 78 GLY G 67 ALA G 19	None None HEM G 200 ( 3.9A) None None	1.25A	4qvnH-2zonG: undetectable 4qvnN-2zonG: undetectable	4qvnH-2zonG: 18.81 4qvnN-2zonG: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_B_BO2B201_0 (PROTEASOME SUBUNIT BETA TYPE-1 PROTEASOME SUBUNIT BETA TYPE-2)	2zon	CYTOCHROME C551 (Achromobacter xylosoxidans)	5 / 12	SER G 18 THR G 74 ALA G 78 GLY G 67 ALA G 19	None None HEM G 200 ( 3.9A) None None	1.22A	6hwdV-2zonG: undetectable 6hwdb-2zonG: undetectable	6hwdV-2zonG: 21.78 6hwdb-2zonG: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_N_BO2N201_0 (PROTEASOME SUBUNIT BETA TYPE-1 PROTEASOME SUBUNIT BETA TYPE-2)	2zon	CYTOCHROME C551 (Achromobacter xylosoxidans)	5 / 12	SER G 18 THR G 74 ALA G 78 GLY G 67 ALA G 19	None None HEM G 200 ( 3.9A) None None	1.22A	6hwdH-2zonG: undetectable 6hwdN-2zonG: undetectable	6hwdH-2zonG: 21.78 6hwdN-2zonG: 22.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3FC6_C_REAC501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","2zon","CYTOCHROME C551","Achromobacter xylosoxidans",5,"VAL G  79;ALA G  85;ALA G  86;LEU G  34;VAL G  55","HEM G 200 ( 4.5A);None;None;None;HEM G 200 ( 4.8A)","1.00A","3fc6C-2zonG:undetectable","3fc6C-2zonG:17.99"],["4QVN_B_BO2B201_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-1","2zon","CYTOCHROME C551","Achromobacter xylosoxidans",5,"SER G  18;THR G  74;ALA G  78;GLY G  67;ALA G  19","None;None;HEM G 200 ( 3.9A);None;None","1.25A","4qvnV-2zonG:undetectable;4qvnb-2zonG:undetectable","4qvnV-2zonG:18.81;4qvnb-2zonG:22.63"],["4QVN_N_BO2N201_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-1","2zon","CYTOCHROME C551","Achromobacter xylosoxidans",5,"SER G  18;THR G  74;ALA G  78;GLY G  67;ALA G  19","None;None;HEM G 200 ( 3.9A);None;None","1.25A","4qvnH-2zonG:undetectable;4qvnN-2zonG:undetectable","4qvnH-2zonG:18.81;4qvnN-2zonG:22.63"],["6HWD_B_BO2B201_0","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2","2zon","CYTOCHROME C551","Achromobacter xylosoxidans",5,"SER G  18;THR G  74;ALA G  78;GLY G  67;ALA G  19","None;None;HEM G 200 ( 3.9A);None;None","1.22A","6hwdV-2zonG:undetectable;6hwdb-2zonG:undetectable","6hwdV-2zonG:21.78;6hwdb-2zonG:22.34"],["6HWD_N_BO2N201_0","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2","2zon","CYTOCHROME C551","Achromobacter xylosoxidans",5,"SER G  18;THR G  74;ALA G  78;GLY G  67;ALA G  19","None;None;HEM G 200 ( 3.9A);None;None","1.22A","6hwdH-2zonG:undetectable;6hwdN-2zonG:undetectable","6hwdH-2zonG:21.78;6hwdN-2zonG:22.34"]]