SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 4 ARG A 456
ALA A 480
ALA A 353
GLU A 355
 None
 1.20A 1e7bA-2zpaA:
undetectable		 1e7bA-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 4 ARG A 456
ALA A 480
ALA A 353
GLU A 355
 None
 1.17A 1e7bB-2zpaA:
undetectable		 1e7bB-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 5 ARG A 456
ALA A 480
ALA A 353
GLU A 355
 None
 1.13A 1e7cA-2zpaA:
undetectable		 1e7cA-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 7 TRP A 359
LEU A 385
LEU A 372
LEU A 367
 None
 0.86A 1gtiA-2zpaA:
undetectable		 1gtiA-2zpaA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 GLY A 293
GLY A 297
PHE A 298
LEU A 299
 None
 0.71A 1jhvA-2zpaA:
undetectable		 1jhvA-2zpaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 SER A 374
GLY A 297
GLY A 293
GLN A 289
 None
 0.86A 1jr1B-2zpaA:
undetectable		 1jr1B-2zpaA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 5 LEU A 609
LEU A 612
LEU A 599
LEU A 601
 None
 1.03A 2ab2B-2zpaA:
undetectable		 2ab2B-2zpaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		5 / 9 LEU A 591
PHE A 584
LEU A 616
LEU A 602
ALA A 611
 None
 1.41A 2bxeA-2zpaA:
undetectable		 2bxeA-2zpaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 4 ASP A 338
LEU A 299
GLY A 295
ARG A 311
 None
 1.43A 2j2pD-2zpaA:
undetectable
2j2pE-2zpaA:
undetectable		 2j2pD-2zpaA:
17.05
2j2pE-2zpaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 4 ASP A 338
LEU A 300
GLY A 297
ARG A 311
 None
 1.44A 2j2pD-2zpaA:
undetectable
2j2pE-2zpaA:
undetectable		 2j2pD-2zpaA:
17.05
2j2pE-2zpaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		3 / 3 ARG A 431
ASN A 446
THR A 593
 None
 0.86A 2q63A-2zpaA:
undetectable		 2q63A-2zpaA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 7 GLN A 641
LEU A 612
LEU A 599
GLY A 596
 None
 0.88A 2qqcD-2zpaA:
undetectable
2qqcE-2zpaA:
undetectable		 2qqcD-2zpaA:
10.48
2qqcE-2zpaA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 PHE A  84
LEU A  22
LEU A 326
ALA A 333
 None
 0.79A 2vcvP-2zpaA:
undetectable		 2vcvP-2zpaA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		3 / 3 TRP A 501
VAL A 437
ARG A 433
 None
 0.80A 3b0wA-2zpaA:
undetectable		 3b0wA-2zpaA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 6 HIS A 162
GLN A  13
LEU A 160
LEU A  10
 None
 1.05A 3bgdA-2zpaA:
2.5		 3bgdA-2zpaA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		5 / 11 GLY A 375
ALA A 376
ILE A 461
GLY A 407
ILE A 405
 None
ACO  A 700 ( 4.5A)
ACO  A 700 (-4.1A)
None
None
 1.06A 3ebzB-2zpaA:
undetectable		 3ebzB-2zpaA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 ALA A 131
ILE A 130
ARG A 386
PRO A 392
 None
 1.03A 3fxrA-2zpaA:
undetectable		 3fxrA-2zpaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 PHE A  84
ALA A  86
ALA A  90
LEU A 326
 None
 0.74A 3l4dA-2zpaA:
undetectable		 3l4dA-2zpaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 PHE A  84
ALA A  86
ALA A  90
LEU A 326
 None
 0.74A 3l4dD-2zpaA:
undetectable		 3l4dD-2zpaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 6 THR A 593
CYH A 597
GLY A 596
ASP A 551
 None
 1.18A 3w9tE-2zpaA:
undetectable		 3w9tE-2zpaA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		3 / 3 ASN A 446
GLU A 544
ARG A 543
 None
 1.08A 3wxoA-2zpaA:
undetectable		 3wxoA-2zpaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 8 ASP A 551
SER A 594
ARG A 600
GLY A 445
 None
 0.94A 4af0A-2zpaA:
undetectable		 4af0A-2zpaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 7 PRO A 366
ASP A 362
SER A 361
TRP A 359
 None
 1.23A 4k7gB-2zpaA:
undetectable		 4k7gB-2zpaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 5 SER A  26
GLY A  27
ARG A 153
GLU A 110
 None
 1.06A 4r82A-2zpaA:
undetectable
4r82B-2zpaA:
undetectable		 4r82A-2zpaA:
15.15
4r82B-2zpaA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		3 / 3 SER A 100
ALA A  76
VAL A  77
 None
 0.61A 4x20C-2zpaA:
undetectable		 4x20C-2zpaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 6 ALA A 646
GLN A 647
LEU A 649
LEU A 609
 None
 1.26A 4xp3A-2zpaA:
undetectable		 4xp3A-2zpaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 5 ARG A 387
GLN A 394
PRO A 392
ASP A 125
 None
 1.46A 4z4hA-2zpaA:
undetectable		 4z4hA-2zpaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		3 / 3 ASP A 125
ARG A 379
ARG A 460
 None
 0.98A 5eajB-2zpaA:
undetectable		 5eajB-2zpaA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		5 / 12 LEU A 500
PHE A 503
LEU A 476
ALA A 376
LEU A 373
 ACO  A 700 ( 4.6A)
ACO  A 700 (-3.8A)
None
ACO  A 700 ( 4.5A)
None
 1.24A 5ienB-2zpaA:
undetectable		 5ienB-2zpaA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		5 / 12 PHE A 503
TRP A 504
ARG A 502
GLY A 498
THR A 497
 ACO  A 700 (-3.8A)
None
None
None
None
 1.20A 5o4yD-2zpaA:
undetectable
5o4yE-2zpaA:
undetectable		 5o4yD-2zpaA:
2.85
5o4yE-2zpaA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 6 PHE A 503
TRP A 504
ARG A 502
GLY A 498
 ACO  A 700 (-3.8A)
None
None
None
 0.88A 5o4yF-2zpaA:
undetectable		 5o4yF-2zpaA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		4 / 7 PHE A  84
ARG A 122
ASP A  85
SER A  93
 None
 1.22A 5uxcA-2zpaA:
2.4		 5uxcA-2zpaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		5 / 10 VAL A 260
LEU A 283
GLY A 204
LEU A 208
GLN A 211
 None
None
ADP  A 800 (-2.7A)
None
ADP  A 800 (-4.0A)
 1.22A 6czmE-2zpaA:
undetectable
6czmF-2zpaA:
undetectable		 6czmE-2zpaA:
21.16
6czmF-2zpaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2zpa UNCHARACTERIZED
PROTEIN YPFI
(Escherichia
coli) 		3 / 3 TRP A  49
ILE A  50
ASP A  79
 None
 0.74A 6i0y7-2zpaA:
undetectable		 6i0y7-2zpaA:
3.05