SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		5 / 11 ASP H  62
GLY H  65
LEU H  80
PHE H  69
TYR H  90
 None
GOL  H 214 ( 3.7A)
None
None
None
 1.14A 2azyA-2zpkH:
undetectable		 2azyA-2zpkH:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.36A 3nloA-2zpkH:
undetectable
3nloB-2zpkH:
undetectable		 3nloA-2zpkH:
18.36
3nloB-2zpkH:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 6 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.36A 3nlyA-2zpkH:
undetectable
3nlyB-2zpkH:
undetectable		 3nlyA-2zpkH:
20.10
3nlyB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 8 ILE H  77
TYR H  79
SER H  70
THR H  17
 None
 0.56A 3pwwA-2zpkH:
undetectable		 3pwwA-2zpkH:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.30A 4ctrA-2zpkH:
undetectable
4ctrB-2zpkH:
undetectable		 4ctrA-2zpkH:
20.10
4ctrB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.32A 4cttA-2zpkH:
undetectable
4cttB-2zpkH:
undetectable		 4cttA-2zpkH:
20.10
4cttB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5F_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.32A 4k5fA-2zpkH:
undetectable
4k5fB-2zpkH:
undetectable		 4k5fA-2zpkH:
20.10
4k5fB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 6 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.32A 4ugzA-2zpkH:
undetectable
4ugzB-2zpkH:
undetectable		 4ugzA-2zpkH:
20.10
4ugzB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.33A 4uh0A-2zpkH:
undetectable
4uh0B-2zpkH:
undetectable		 4uh0A-2zpkH:
20.10
4uh0B-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 6 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.31A 4uh3A-2zpkH:
undetectable
4uh3B-2zpkH:
undetectable		 4uh3A-2zpkH:
20.10
4uh3B-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.33A 4uppA-2zpkH:
undetectable
4uppB-2zpkH:
undetectable		 4uppA-2zpkH:
20.10
4uppB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.34A 5adaA-2zpkH:
undetectable
5adaB-2zpkH:
undetectable		 5adaA-2zpkH:
20.10
5adaB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		3 / 3 SER H 203
ALA H 198
VAL H 197
 None
 0.57A 5eypA-2zpkH:
undetectable		 5eypA-2zpkH:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.25A 5unuA-2zpkH:
undetectable
5unuB-2zpkH:
undetectable		 5unuA-2zpkH:
20.10
5unuB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.30A 5unwA-2zpkH:
undetectable
5unwB-2zpkH:
undetectable		 5unwA-2zpkH:
20.10
5unwB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 PHE H  69
GLU H  95
VAL H  37
TRP H  47
 None
 1.27A 5unwA-2zpkH:
undetectable
5unwB-2zpkH:
undetectable		 5unwA-2zpkH:
20.10
5unwB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.23A 5unxA-2zpkH:
undetectable
5unxB-2zpkH:
undetectable		 5unxA-2zpkH:
20.10
5unxB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 6 PHE H  69
GLU H  95
VAL H  37
TRP H  47
 None
 1.24A 5unxA-2zpkH:
undetectable
5unxB-2zpkH:
undetectable		 5unxA-2zpkH:
20.10
5unxB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.28A 5unyA-2zpkH:
undetectable
5unyB-2zpkH:
undetectable		 5unyA-2zpkH:
20.10
5unyB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 PHE H  69
GLU H  95
VAL H  37
TRP H  47
 None
 1.29A 5uo3A-2zpkH:
undetectable
5uo3B-2zpkH:
undetectable		 5uo3A-2zpkH:
19.71
5uo3B-2zpkH:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.34A 5vusA-2zpkH:
undetectable
5vusB-2zpkH:
undetectable		 5vusA-2zpkH:
20.10
5vusB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  69
GLU H  95
 None
 1.34A 5vuuA-2zpkH:
undetectable
5vuuB-2zpkH:
undetectable		 5vuuA-2zpkH:
20.10
5vuuB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV0_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)
(Mus
musculus) 		4 / 6 PHE H  69
GLU H  95
VAL H  37
TRP H  47
 None
 1.33A 5vv0A-2zpkH:
undetectable
5vv0B-2zpkH:
undetectable		 5vv0A-2zpkH:
19.71
5vv0B-2zpkH:
19.71