SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 10 GLY Y  54
ALA Y 289
ASN Y 302
ALA Y 301
ILE Y 285
 None
 0.98A 1likA-2zqpY:
undetectable		 1likA-2zqpY:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		3 / 3 SER Y  63
THR Y  36
GLN Y 161
 None
 0.65A 2fk8A-2zqpY:
undetectable		 2fk8A-2zqpY:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 12 VAL Y 157
PHE Y  67
PHE Y  56
LEU Y  48
ALA Y 133
 None
 1.25A 3apvA-2zqpY:
undetectable		 3apvA-2zqpY:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 12 VAL Y 157
PHE Y  67
PHE Y  56
LEU Y  48
ALA Y 133
 None
 1.26A 3apvB-2zqpY:
undetectable		 3apvB-2zqpY:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 4 ILE Y  58
ARG Y  69
ILE Y  59
THR Y 307
 None
 0.89A 3ia4C-2zqpY:
undetectable		 3ia4C-2zqpY:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 11 LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
SER Y  71
 None
 1.46A 3ko0C-2zqpY:
undetectable
3ko0D-2zqpY:
undetectable
3ko0E-2zqpY:
undetectable
3ko0F-2zqpY:
undetectable		 3ko0C-2zqpY:
11.03
3ko0D-2zqpY:
11.03
3ko0E-2zqpY:
11.03
3ko0F-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 11 SER Y  71
LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
 None
 1.35A 3ko0C-2zqpY:
undetectable
3ko0D-2zqpY:
undetectable
3ko0E-2zqpY:
undetectable
3ko0F-2zqpY:
undetectable		 3ko0C-2zqpY:
11.03
3ko0D-2zqpY:
11.03
3ko0E-2zqpY:
11.03
3ko0F-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 5 PHE Y 129
PHE Y 286
PHE Y 134
PHE Y  56
 None
 1.34A 3ko0F-2zqpY:
undetectable
3ko0G-2zqpY:
undetectable		 3ko0F-2zqpY:
11.03
3ko0G-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 5 PHE Y 134
PHE Y  56
PHE Y 129
PHE Y 286
 None
 1.32A 3ko0F-2zqpY:
undetectable
3ko0G-2zqpY:
undetectable		 3ko0F-2zqpY:
11.03
3ko0G-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 11 LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
SER Y  71
 None
 1.38A 3ko0E-2zqpY:
undetectable
3ko0F-2zqpY:
undetectable
3ko0G-2zqpY:
undetectable
3ko0H-2zqpY:
undetectable		 3ko0E-2zqpY:
11.03
3ko0F-2zqpY:
11.03
3ko0G-2zqpY:
11.03
3ko0H-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 11 SER Y  71
LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
 None
 1.46A 3ko0K-2zqpY:
undetectable
3ko0L-2zqpY:
undetectable
3ko0M-2zqpY:
undetectable
3ko0N-2zqpY:
undetectable		 3ko0K-2zqpY:
11.03
3ko0L-2zqpY:
11.03
3ko0M-2zqpY:
11.03
3ko0N-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 11 LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
SER Y  71
 None
 1.45A 3ko0O-2zqpY:
undetectable
3ko0P-2zqpY:
undetectable
3ko0Q-2zqpY:
undetectable
3ko0R-2zqpY:
undetectable		 3ko0O-2zqpY:
11.03
3ko0P-2zqpY:
11.03
3ko0Q-2zqpY:
11.03
3ko0R-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 11 SER Y  71
LEU Y  61
SER Y  63
PHE Y  62
ILE Y 192
 None
 1.43A 3ko0Q-2zqpY:
undetectable
3ko0R-2zqpY:
undetectable
3ko0S-2zqpY:
undetectable
3ko0T-2zqpY:
undetectable		 3ko0Q-2zqpY:
11.03
3ko0R-2zqpY:
11.03
3ko0S-2zqpY:
11.03
3ko0T-2zqpY:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 7 VAL Y  39
LEU Y 135
GLN Y 161
LEU Y  75
 None
 0.93A 3qeoB-2zqpY:
undetectable		 3qeoB-2zqpY:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 8 PRO Y 382
ILE Y 385
TRP Y 196
ILE Y 224
 None
 1.06A 3sfeB-2zqpY:
undetectable
3sfeC-2zqpY:
1.6		 3sfeB-2zqpY:
19.13
3sfeC-2zqpY:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 9 ILE Y  77
ALA Y 172
ILE Y 120
ILE Y 165
THR Y 184
 None
 1.21A 3tq8A-2zqpY:
undetectable		 3tq8A-2zqpY:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		3 / 3 PHE Y 331
LYS Y 102
SER Y 101
 None
 1.12A 3tyeB-2zqpY:
undetectable		 3tyeB-2zqpY:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 12 ILE Y 403
GLY Y 406
ALA Y 232
VAL Y 271
ILE Y 274
 None
 1.12A 4rvgA-2zqpY:
undetectable		 4rvgA-2zqpY:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 7 GLY Y  65
TYR Y  28
SER Y  63
ASN Y  66
 None
 1.08A 4ws0A-2zqpY:
undetectable		 4ws0A-2zqpY:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 4 GLY Y  38
VAL Y 157
PHE Y  73
ILE Y  72
 None
 0.78A 4xv2B-2zqpY:
undetectable		 4xv2B-2zqpY:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 7 THR Y 411
LEU Y  25
VAL Y  18
THR Y  21
 None
 1.00A 5e4dA-2zqpY:
undetectable
5e4dB-2zqpY:
undetectable		 5e4dA-2zqpY:
18.75
5e4dB-2zqpY:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 7 VAL Y 407
THR Y 411
VAL Y  18
THR Y  21
 None
 1.04A 5e4dA-2zqpY:
undetectable
5e4dB-2zqpY:
undetectable		 5e4dA-2zqpY:
18.75
5e4dB-2zqpY:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 12 ILE Y 314
PRO Y 284
PHE Y 304
ASN Y 302
GLY Y 311
 None
 1.24A 5il1A-2zqpY:
undetectable		 5il1A-2zqpY:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 7 GLY Y  57
GLY Y  53
PHE Y 134
LEU Y 130
GLU Y 195
 None
 1.41A 5izfA-2zqpY:
undetectable		 5izfA-2zqpY:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 12 ILE Y 314
PRO Y 284
PHE Y 304
ASN Y 302
GLY Y 311
 None
 1.21A 5k7uA-2zqpY:
undetectable		 5k7uA-2zqpY:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		6 / 10 ILE Y 283
ILE Y 280
THR Y  82
ILE Y  85
ILE Y  86
ILE Y  89
 None
 1.38A 5murE-2zqpY:
undetectable		 5murE-2zqpY:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 10 VAL Y  39
ILE Y  44
LEU Y  48
ARG Y 141
GLY Y 136
 None
 1.09A 5mxbA-2zqpY:
undetectable		 5mxbA-2zqpY:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 8 TYR Y  80
ILE Y  81
THR Y 184
ILE Y 187
 None
 0.91A 5mzrE-2zqpY:
undetectable		 5mzrE-2zqpY:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 12 MET Y  78
GLY Y 191
VAL Y 193
ARG Y  69
GLN Y 282
 None
 1.35A 5uc3B-2zqpY:
undetectable		 5uc3B-2zqpY:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 7 THR Y 323
TYR Y 324
VAL Y 329
PRO Y 333
 None
 0.93A 6cduA-2zqpY:
undetectable
6cduE-2zqpY:
undetectable		 6cduA-2zqpY:
19.30
6cduE-2zqpY:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 8 VAL Y 329
PRO Y 333
THR Y 323
TYR Y 324
 None
 0.92A 6cduD-2zqpY:
undetectable
6cduE-2zqpY:
undetectable		 6cduD-2zqpY:
19.30
6cduE-2zqpY:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		4 / 7 VAL Y 329
PRO Y 333
THR Y 323
TYR Y 324
 None
 0.94A 6cduH-2zqpY:
undetectable
6cduI-2zqpY:
undetectable		 6cduH-2zqpY:
19.30
6cduI-2zqpY:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT
(Thermus
thermophilus) 		5 / 10 ILE Y 320
LEU Y 402
LEU Y 373
GLY Y 371
ASN Y 267
 None
 1.36A 6r2eB-2zqpY:
undetectable		 6r2eB-2zqpY:
21.02