SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 7 GLY A 220
ARG A 223
ILE A 165
GLY A 185
 None
 0.75A 11gsB-2zqqA:
undetectable		 11gsB-2zqqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 GLY A 217
GLU A 189
LEU A 212
ARG A 146
GLY A 185
 None
 1.49A 1i7qA-2zqqA:
undetectable		 1i7qA-2zqqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 ILE A 214
GLY A 217
GLU A 189
ARG A 146
GLY A 185
 None
 1.45A 1i7qA-2zqqA:
undetectable		 1i7qA-2zqqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 ILE A 214
GLY A 217
GLU A 189
ARG A 146
GLY A 186
 None
 1.12A 1i7qA-2zqqA:
undetectable		 1i7qA-2zqqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		3 / 3 ASP A 265
TYR A 268
GLU A 132
 None
 0.74A 1vm1A-2zqqA:
undetectable		 1vm1A-2zqqA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 ALA A 193
GLY A 185
GLY A 187
ILE A 165
LEU A 182
 None
 1.11A 1x1aA-2zqqA:
undetectable		 1x1aA-2zqqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 ARG A 146
PHE A 137
ALA A 141
ILE A  94
ILE A 129
 None
 1.27A 2bjfA-2zqqA:
undetectable		 2bjfA-2zqqA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 GLY A 185
GLU A 189
ARG A 146
GLY A 218
GLU A 209
 None
 1.37A 2fn1A-2zqqA:
undetectable		 2fn1A-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 ILE A 161
GLY A 185
GLU A 189
GLY A 218
GLU A 209
 None
 1.38A 2fn1A-2zqqA:
undetectable		 2fn1A-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 GLY A 185
GLU A 189
ARG A 146
GLY A 218
GLU A 209
 None
 1.40A 2fn1B-2zqqA:
undetectable		 2fn1B-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 ILE A 161
GLY A 185
GLU A 189
GLY A 218
GLU A 209
 None
 1.37A 2fn1B-2zqqA:
undetectable		 2fn1B-2zqqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 6 LEU A 107
ILE A  94
ILE A 254
LEU A 192
 None
 0.83A 2xkwB-2zqqA:
undetectable		 2xkwB-2zqqA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 GLY A 206
LEU A 182
ASP A 244
LEU A 243
GLU A 189
 None
 1.20A 2zw9B-2zqqA:
undetectable		 2zw9B-2zqqA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		3 / 3 ASP A 273
LEU A 274
GLN A 281
 None
 0.80A 3g4lA-2zqqA:
undetectable		 3g4lA-2zqqA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 8 GLY A 220
ARG A 223
ILE A 165
GLY A 185
 None
 0.73A 3n9jB-2zqqA:
undetectable		 3n9jB-2zqqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 5 LEU A 192
LEU A 207
GLY A 206
GLY A 185
 None
 0.76A 3si7C-2zqqA:
undetectable
3si7D-2zqqA:
undetectable		 3si7C-2zqqA:
20.55
3si7D-2zqqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 GLY A 220
ILE A 228
VAL A 251
MET A 205
LEU A 188
 None
 1.14A 4a81A-2zqqA:
undetectable		 4a81A-2zqqA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 9 LEU A 118
VAL A 164
LEU A 107
ILE A 168
GLY A  93
 None
 1.12A 4kukA-2zqqA:
undetectable		 4kukA-2zqqA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 ALA A 267
GLY A 181
LEU A 182
ALA A 178
GLU A 189
 None
 1.07A 4lg1A-2zqqA:
undetectable		 4lg1A-2zqqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 LEU A  77
THR A 175
ILE A 129
LEU A 190
ILE A 168
 None
 1.12A 4nx7A-2zqqA:
undetectable		 4nx7A-2zqqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 11 LEU A 224
GLY A 252
LEU A 243
ARG A 241
SER A 239
 None
 1.18A 4zbqA-2zqqA:
undetectable		 4zbqA-2zqqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 5 SER A 255
ARG A 226
GLU A 298
ARG A 197
 None
 0.87A 5cdqA-2zqqA:
undetectable
5cdqB-2zqqA:
undetectable
5cdqC-2zqqA:
undetectable		 5cdqA-2zqqA:
21.89
5cdqB-2zqqA:
23.27
5cdqC-2zqqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 5 SER A 255
ARG A 226
GLU A 298
ARG A 197
 None
 0.85A 5cdqR-2zqqA:
undetectable
5cdqS-2zqqA:
undetectable
5cdqT-2zqqA:
undetectable		 5cdqR-2zqqA:
21.89
5cdqS-2zqqA:
23.27
5cdqT-2zqqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		4 / 8 THR A 303
GLY A 304
ALA A 306
GLY A 296
 None
 0.60A 5vw9A-2zqqA:
undetectable		 5vw9A-2zqqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 10 LEU A 107
ILE A 165
LEU A 184
ALA A 139
GLU A  76
 None
 1.16A 5y7pG-2zqqA:
undetectable		 5y7pG-2zqqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens) 		5 / 12 LEU A 224
GLY A 187
GLY A 185
ILE A 165
LEU A 192
 None
 0.99A 6ecxA-2zqqA:
undetectable		 6ecxA-2zqqA:
23.74