SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 8 GLU A 233
ILE A   7
LEU A   2
GLU A  23
VAL A  30
 None
 1.38A 1a29A-2zr2A:
undetectable		 1a29A-2zr2A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 PHE A 212
VAL A 309
VAL A 372
ILE A 358
TYR A 338
 None
None
AMP  A1001 (-4.8A)
None
None
 1.26A 1fm4A-2zr2A:
undetectable		 1fm4A-2zr2A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ALA A 407
SER A 229
TRP A 319
LEU A 207
 None
 1.11A 1gahA-2zr2A:
undetectable		 1gahA-2zr2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 ILE A 216
VAL A 278
ILE A 194
ILE A 430
 None
 0.86A 1uwhB-2zr2A:
undetectable		 1uwhB-2zr2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 106
PRO A 107
LEU A   2
 None
 0.61A 2po5B-2zr2A:
undetectable		 2po5B-2zr2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 LEU A 106
PRO A 107
LEU A   2
 None
 0.58A 2po7B-2zr2A:
undetectable		 2po7B-2zr2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		6 / 12 VAL A 433
TRP A 435
ILE A 417
LEU A 199
PHE A 202
THR A 438
 None
 1.38A 2w3vA-2zr2A:
undetectable		 2w3vA-2zr2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ALA A 416
ILE A 417
ASN A 420
PRO A 431
 None
 0.58A 3fxrA-2zr2A:
undetectable		 3fxrA-2zr2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 THR A  42
LYS A  15
GLU A  39
 None
 1.00A 3ijdB-2zr2A:
undetectable		 3ijdB-2zr2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 228
GLY A 259
LEU A 403
VAL A 351
ALA A 352
 None
 1.15A 3t7vA-2zr2A:
undetectable		 3t7vA-2zr2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 169
GLY A 171
LEU A 166
GLU A 167
 None
None
None
SO4  A2007 ( 4.4A)
 1.12A 3tgvB-2zr2A:
undetectable		 3tgvB-2zr2A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 186
LEU A 166
ILE A 443
ILE A 296
LEU A 434
 None
 1.15A 3vw1B-2zr2A:
undetectable		 3vw1B-2zr2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 390
ARG A 392
ILE A 265
 None
 0.90A 4b7qA-2zr2A:
undetectable		 4b7qA-2zr2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 ARG A 390
ARG A 392
ILE A 265
 None
 0.83A 4b7qC-2zr2A:
undetectable		 4b7qC-2zr2A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 4 LEU A 106
PRO A 107
LEU A   2
ILE A   7
 None
 0.78A 4f4dB-2zr2A:
undetectable		 4f4dB-2zr2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A 171
GLY A 170
ILE A 168
PHE A 440
ILE A 443
 None
 1.28A 4fglA-2zr2A:
undetectable
4fglB-2zr2A:
undetectable		 4fglA-2zr2A:
19.64
4fglB-2zr2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 ARG A 283
ARG A 298
PHE A 302
ARG A 412
 AMP  A1001 (-3.3A)
SO4  A2003 (-3.0A)
AMP  A1001 (-3.5A)
SO4  A2005 ( 3.1A)
 0.89A 4k87A-2zr2A:
23.6		 4k87A-2zr2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 12 GLU A 285
VAL A 238
PRO A 251
THR A 252
GLU A 306
 AMP  A1001 (-3.6A)
None
None
AMP  A1001 ( 4.5A)
None
 1.27A 4k88A-2zr2A:
24.0		 4k88A-2zr2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 LEU A 106
PRO A 107
LEU A   2
ILE A   7
 None
 0.77A 4klrA-2zr2A:
undetectable		 4klrA-2zr2A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 11 ALA A 198
SER A 411
ILE A 296
LEU A 166
THR A 438
 None
AMP  A1001 (-3.1A)
None
None
None
 1.29A 4qi9C-2zr2A:
undetectable		 4qi9C-2zr2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 5 ILE A 414
VAL A 415
PHE A 368
HIS A 303
 None
 1.25A 4rzvA-2zr2A:
1.7		 4rzvA-2zr2A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 306
THR A 230
HIS A 255
 None
 0.82A 4ydqB-2zr2A:
21.8		 4ydqB-2zr2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 8 PHE A 202
HIS A 421
PRO A 431
ILE A 417
 None
 1.14A 5vkqB-2zr2A:
5.2
5vkqC-2zr2A:
5.2		 5vkqB-2zr2A:
13.12
5vkqC-2zr2A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		4 / 6 SER A 411
GLU A 285
ARG A 298
ASP A 234
 AMP  A1001 (-3.1A)
AMP  A1001 (-3.6A)
SO4  A2003 (-3.0A)
None
 0.82A 5zw4A-2zr2A:
undetectable		 5zw4A-2zr2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ARG A 283
GLU A 285
PHE A 302
ALA A 409
GLU A 370
 AMP  A1001 (-3.3A)
AMP  A1001 (-3.6A)
AMP  A1001 (-3.5A)
AMP  A1001 (-3.5A)
AMP  A1001 ( 3.2A)
 1.20A 6bniA-2zr2A:
10.2		 6bniA-2zr2A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ARG A 283
GLU A 285
PHE A 302
GLU A 370
ARG A 412
 AMP  A1001 (-3.3A)
AMP  A1001 (-3.6A)
AMP  A1001 (-3.5A)
AMP  A1001 ( 3.2A)
SO4  A2005 ( 3.1A)
 0.78A 6bniA-2zr2A:
10.2		 6bniA-2zr2A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ARG A 283
GLU A 285
PHE A 302
ALA A 409
GLU A 370
 AMP  A1001 (-3.3A)
AMP  A1001 (-3.6A)
AMP  A1001 (-3.5A)
AMP  A1001 (-3.5A)
AMP  A1001 ( 3.2A)
 1.24A 6bniB-2zr2A:
11.6		 6bniB-2zr2A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 2zr2 SERYL-TRNA
SYNTHETASE
(Pyrococcus
horikoshii) 		5 / 10 ARG A 283
GLU A 285
PHE A 302
GLU A 370
ARG A 412
 AMP  A1001 (-3.3A)
AMP  A1001 (-3.6A)
AMP  A1001 (-3.5A)
AMP  A1001 ( 3.2A)
SO4  A2005 ( 3.1A)
 0.77A 6bniB-2zr2A:
11.6		 6bniB-2zr2A:
8.35