SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zsg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.80A 1p7lD-2zsgA:
undetectable		 1p7lD-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.78A 1p7lC-2zsgA:
undetectable		 1p7lC-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.80A 1rg9B-2zsgA:
undetectable		 1rg9B-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.79A 1rg9A-2zsgA:
undetectable		 1rg9A-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.80A 1rg9D-2zsgA:
undetectable		 1rg9D-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.78A 1rg9C-2zsgA:
undetectable		 1rg9C-2zsgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 LEU A  20
PHE A 120
ALA A  97
LEU A  46
 None
 1.02A 1ukbA-2zsgA:
undetectable		 1ukbA-2zsgA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.90A 1v54N-2zsgA:
undetectable
1v54W-2zsgA:
undetectable		 1v54N-2zsgA:
20.79
1v54W-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.89A 1v55A-2zsgA:
undetectable
1v55J-2zsgA:
undetectable		 1v55A-2zsgA:
20.79
1v55J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.92A 1v55N-2zsgA:
undetectable
1v55W-2zsgA:
undetectable		 1v55N-2zsgA:
20.79
1v55W-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.93A 2dyrN-2zsgA:
undetectable
2dyrW-2zsgA:
undetectable		 2dyrN-2zsgA:
20.79
2dyrW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.93A 2einN-2zsgA:
undetectable
2einW-2zsgA:
undetectable		 2einN-2zsgA:
20.79
2einW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 THR A 156
ALA A 152
ILE A 160
ILE A 215
LEU A 352
 None
 1.16A 2rlcA-2zsgA:
undetectable		 2rlcA-2zsgA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.93A 3abkA-2zsgA:
undetectable
3abkJ-2zsgA:
undetectable		 3abkA-2zsgA:
20.79
3abkJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.91A 3ablA-2zsgA:
2.4
3ablJ-2zsgA:
undetectable		 3ablA-2zsgA:
20.79
3ablJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.88A 3abmN-2zsgA:
2.6
3abmW-2zsgA:
undetectable		 3abmN-2zsgA:
20.79
3abmW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.92A 3ag1N-2zsgA:
undetectable
3ag1W-2zsgA:
undetectable		 3ag1N-2zsgA:
20.79
3ag1W-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.91A 3ag3A-2zsgA:
undetectable
3ag3J-2zsgA:
undetectable		 3ag3A-2zsgA:
20.79
3ag3J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.89A 3ag3N-2zsgA:
2.9
3ag3W-2zsgA:
undetectable		 3ag3N-2zsgA:
20.79
3ag3W-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.91A 3asnN-2zsgA:
2.3
3asnW-2zsgA:
undetectable		 3asnN-2zsgA:
20.79
3asnW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A  44
PHE A 115
LEU A 107
ALA A 114
 None
 0.93A 3hrdA-2zsgA:
undetectable
3hrdB-2zsgA:
undetectable		 3hrdA-2zsgA:
21.54
3hrdB-2zsgA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 THR A  87
LEU A  91
ALA A  18
SER A  48
 None
 0.77A 3kp6A-2zsgA:
undetectable		 3kp6A-2zsgA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A  10
ALA A  97
ILE A  93
ILE A  45
ILE A  11
 None
 1.04A 3oxcB-2zsgA:
undetectable		 3oxcB-2zsgA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		6 / 12 GLN A  63
PHE A  38
GLY A  40
GLY A  37
SER A  32
ALA A  30
 None
 1.29A 3sueD-2zsgA:
undetectable		 3sueD-2zsgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 PHE A  38
GLY A  40
GLY A  37
SER A  32
ALA A  30
 None
 0.92A 3sufC-2zsgA:
undetectable		 3sufC-2zsgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
ARG A 151
MET A 177
THR A 176
 None
 0.89A 3wg7A-2zsgA:
2.6
3wg7J-2zsgA:
undetectable		 3wg7A-2zsgA:
20.79
3wg7J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.95A 3wg7N-2zsgA:
2.9
3wg7W-2zsgA:
undetectable		 3wg7N-2zsgA:
20.79
3wg7W-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 PHE A  38
ILE A  24
ASN A  23
GLU A  67
 None
 1.07A 4a97D-2zsgA:
undetectable		 4a97D-2zsgA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 PHE A  38
ILE A  24
ASN A  23
GLU A  67
 None
 1.10A 4a97H-2zsgA:
undetectable		 4a97H-2zsgA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ASP A 271
ILE A 305
VAL A 317
GLY A 302
 None
 0.77A 4acaC-2zsgA:
undetectable		 4acaC-2zsgA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ASP A 271
ILE A 305
VAL A 317
GLY A 302
 None
 0.75A 4acbC-2zsgA:
undetectable		 4acbC-2zsgA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 PHE A 187
VAL A 185
GLU A 174
 None
 0.84A 4fvqA-2zsgA:
undetectable		 4fvqA-2zsgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.73A 4kttB-2zsgA:
undetectable		 4kttB-2zsgA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ALA A  30
GLU A 298
ASP A 229
ILE A 142
 None
None
ZN  A1001 (-3.1A)
None
 0.73A 4ndnB-2zsgA:
undetectable		 4ndnB-2zsgA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 PHE A 319
GLU A 301
MET A 132
VAL A 340
 None
 1.46A 4uh6A-2zsgA:
undetectable
4uh6B-2zsgA:
undetectable		 4uh6A-2zsgA:
20.95
4uh6B-2zsgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 MET A 164
GLU A 168
LEU A 172
 None
 0.53A 4v2oB-2zsgA:
undetectable		 4v2oB-2zsgA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 220
ALA A 228
ASP A 338
GLU A 322
THR A 350
 None
None
None
ZN  A1001 (-2.8A)
None
 1.34A 4xt8A-2zsgA:
undetectable		 4xt8A-2zsgA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.95A 5b1aA-2zsgA:
2.6
5b1aJ-2zsgA:
undetectable		 5b1aA-2zsgA:
20.79
5b1aJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ARG A 151
MET A 177
LEU A 173
 None
 1.01A 5b1bA-2zsgA:
undetectable
5b1bJ-2zsgA:
undetectable		 5b1bA-2zsgA:
20.79
5b1bJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.96A 5b3sA-2zsgA:
2.9
5b3sJ-2zsgA:
undetectable		 5b3sA-2zsgA:
20.79
5b3sJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.93A 5b3sN-2zsgA:
undetectable
5b3sW-2zsgA:
undetectable		 5b3sN-2zsgA:
20.79
5b3sW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.94A 5iy5N-2zsgA:
undetectable
5iy5W-2zsgA:
undetectable		 5iy5N-2zsgA:
20.79
5iy5W-2zsgA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 MET A 130
GLU A   5
ARG A   6
 None
 1.08A 5tjyA-2zsgA:
undetectable		 5tjyA-2zsgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 MET A 130
GLU A   5
ARG A   6
 None
 0.97A 5tjzA-2zsgA:
undetectable		 5tjzA-2zsgA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 PHE A 319
GLU A 301
MET A 132
VAL A 340
 None
 1.43A 5vv3A-2zsgA:
undetectable
5vv3B-2zsgA:
undetectable		 5vv3A-2zsgA:
20.95
5vv3B-2zsgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 1.14A 5xdqN-2zsgA:
2.7
5xdqW-2zsgA:
undetectable		 5xdqN-2zsgA:
20.79
5xdqW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.92A 5xdxA-2zsgA:
undetectable
5xdxJ-2zsgA:
undetectable		 5xdxA-2zsgA:
20.79
5xdxJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.94A 5xdxN-2zsgA:
undetectable
5xdxW-2zsgA:
undetectable		 5xdxN-2zsgA:
20.79
5xdxW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 11 GLU A 322
ALA A 257
ALA A 253
ILE A 278
ARG A 275
 ZN  A1001 (-2.8A)
None
None
None
CL  A1005 (-4.4A)
 1.21A 5yk2A-2zsgA:
undetectable		 5yk2A-2zsgA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.97A 5z86J-2zsgA:
undetectable		 5z86J-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 6 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 1.06A 5z86N-2zsgA:
2.8
5z86W-2zsgA:
undetectable		 5z86N-2zsgA:
20.79
5z86W-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
ARG A 151
MET A 177
LEU A 173
 None
 0.90A 5zcoA-2zsgA:
2.9
5zcoJ-2zsgA:
undetectable		 5zcoA-2zsgA:
20.79
5zcoJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
ARG A 151
MET A 177
THR A 176
 None
 0.82A 5zcoA-2zsgA:
2.9
5zcoJ-2zsgA:
undetectable		 5zcoA-2zsgA:
20.79
5zcoJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
ARG A 151
MET A 177
LEU A 173
 None
 1.01A 5zcoN-2zsgA:
undetectable
5zcoW-2zsgA:
undetectable		 5zcoN-2zsgA:
20.79
5zcoW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
MET A 177
THR A 176
LEU A 173
 None
 0.95A 5zcoN-2zsgA:
undetectable
5zcoW-2zsgA:
undetectable		 5zcoN-2zsgA:
20.79
5zcoW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.97A 5zcpA-2zsgA:
2.7
5zcpJ-2zsgA:
undetectable		 5zcpA-2zsgA:
20.79
5zcpJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 8 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 1.09A 5zcpN-2zsgA:
2.5
5zcpW-2zsgA:
undetectable		 5zcpN-2zsgA:
20.79
5zcpW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 7 ILE A 230
ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.96A 5zcqA-2zsgA:
2.2
5zcqJ-2zsgA:
undetectable		 5zcqA-2zsgA:
20.79
5zcqJ-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		5 / 9 ALA A 198
VAL A 216
ALA A 192
SER A 197
GLY A 202
 None
 1.14A 6bklA-2zsgA:
undetectable
6bklB-2zsgA:
undetectable
6bklC-2zsgA:
undetectable
6bklD-2zsgA:
undetectable		 6bklA-2zsgA:
6.85
6bklB-2zsgA:
6.85
6bklC-2zsgA:
6.85
6bklD-2zsgA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		6 / 12 GLN A  63
PHE A  38
GLY A  40
GLY A  37
SER A  32
ALA A  30
 None
 1.34A 6c2mA-2zsgA:
undetectable		 6c2mA-2zsgA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		6 / 12 GLN A  63
PHE A  38
GLY A  40
GLY A  37
SER A  32
ALA A  30
 None
 1.27A 6c2mB-2zsgA:
undetectable		 6c2mB-2zsgA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 ARG A 151
MET A 177
THR A 176
LEU A 173
 None
 0.90A 6nknW-2zsgA:
undetectable		 6nknW-2zsgA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zsg AMINOPEPTIDASE P,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 ILE A 230
ARG A 151
MET A 177
THR A 176
 None
 0.98A 6nmfN-2zsgA:
undetectable
6nmfW-2zsgA:
undetectable		 6nmfN-2zsgA:
20.79
6nmfW-2zsgA:
10.49