SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
 None
None
None
GA4  A 345 (-3.1A)
 1.25A 1mj2B-2zsiA:
undetectable		 1mj2B-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
 None
None
None
GA4  A 345 (-3.1A)
 1.17A 1mj2D-2zsiA:
undetectable		 1mj2D-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
 None
None
None
GA4  A 345 (-3.1A)
 1.22A 1mjoB-2zsiA:
undetectable		 1mjoB-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
 None
None
None
GA4  A 345 (-3.1A)
 1.26A 1mjoA-2zsiA:
undetectable		 1mjoA-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 4 HIS A 119
ALA A 118
PHE A 117
GLY A 115
 None
None
None
GA4  A 345 (-3.1A)
 1.21A 1mjoD-2zsiA:
undetectable		 1mjoD-2zsiA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		3 / 3 ARG A 226
ILE A 291
TRP A 294
 None
 1.01A 1nodB-2zsiA:
undetectable		 1nodB-2zsiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 LEU A 323
HIS A 113
ILE A  24
TYR B  36
TYR A  31
 None
None
GA4  A 345 ( 4.3A)
None
None
 1.45A 1ot7B-2zsiA:
undetectable		 1ot7B-2zsiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 6 ALA A 262
PHE A 251
ASN A 199
ILE A 196
 None
 1.03A 1yc2A-2zsiA:
2.1		 1yc2A-2zsiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 5 ALA A 262
PHE A 251
ASN A 199
ILE A 196
 None
 0.88A 1yc2D-2zsiA:
2.2		 1yc2D-2zsiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 9 LEU A  49
TYR A  48
LEU B  80
LEU B  84
TYR B  36
 None
 1.39A 2bfmA-2zsiA:
4.2
2bfmD-2zsiA:
2.1		 2bfmA-2zsiA:
21.94
2bfmD-2zsiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 6 ASN A 327
HIS A 329
ASN A 326
THR A 318
 None
 1.17A 2hkkA-2zsiA:
undetectable		 2hkkA-2zsiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 6 THR A  20
THR A 318
ASN A 332
ASP A 335
 None
 1.20A 2okcA-2zsiA:
undetectable		 2okcA-2zsiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 5 PHE A 251
PHE A 112
SER A  78
ILE A  70
 None
 1.02A 2v0mD-2zsiA:
undetectable		 2v0mD-2zsiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 ASN A 218
LEU A 282
VAL A 333
ALA A 286
PHE A 321
 None
 1.39A 3nuvA-2zsiA:
undetectable		 3nuvA-2zsiA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 SER A 191
MET A 220
TYR A 127
SER A 124
PHE A 117
 GA4  A 345 (-3.1A)
None
GA4  A 345 (-4.7A)
None
None
 1.32A 3ugrA-2zsiA:
undetectable		 3ugrA-2zsiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 8 HIS A 313
VAL A 285
VAL A 283
ASP A 293
 None
 1.18A 3uy4A-2zsiA:
2.4		 3uy4A-2zsiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 10 ALA A 204
ILE A 185
GLY A 162
ILE A 196
VAL A 211
 None
 0.94A 4j5jB-2zsiA:
undetectable		 4j5jB-2zsiA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 8 LEU A 130
CYH A 131
PHE A 111
TYR A  81
 None
 0.95A 4j7uD-2zsiA:
4.4		 4j7uD-2zsiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 LEU A 130
CYH A 131
PHE A 111
TYR A  81
GLY A 115
 None
None
None
None
GA4  A 345 (-3.1A)
 1.30A 4j7xF-2zsiA:
3.6		 4j7xF-2zsiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 TYR A 127
GLY A 193
GLY A 189
SER A 144
ALA A 158
 GA4  A 345 (-4.7A)
None
None
None
None
 1.15A 4krhB-2zsiA:
3.1		 4krhB-2zsiA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 8 SER A  25
GLU B  54
VAL A 319
THR A 318
 None
None
GA4  A 345 (-4.2A)
None
 1.10A 4lnwA-2zsiA:
undetectable		 4lnwA-2zsiA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 11 LEU A 130
LEU A 134
CYH A 138
VAL A 341
VAL A 284
 None
 1.36A 4mk4B-2zsiA:
3.8		 4mk4B-2zsiA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		3 / 3 ALA A 197
GLN A 307
GLY A 306
 None
 0.62A 4odoC-2zsiA:
undetectable		 4odoC-2zsiA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 8 TYR A 159
PHE A 117
GLY A 222
ASN A 195
 None
 0.91A 4qoiA-2zsiA:
3.0
4qoiB-2zsiA:
2.5		 4qoiA-2zsiA:
20.00
4qoiB-2zsiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		3 / 3 ASN A  58
PHE A  66
TYR A  81
 None
 0.83A 4u15A-2zsiA:
undetectable		 4u15A-2zsiA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.49A 4v2yB-2zsiA:
undetectable		 4v2yB-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.49A 4v2zA-2zsiA:
0.0		 4v2zA-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 8 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.41A 4v30B-2zsiA:
undetectable		 4v30B-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.47A 4v32A-2zsiA:
0.0		 4v32A-2zsiA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.48A 5amiA-2zsiA:
0.0		 5amiA-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.45A 5amjA-2zsiA:
0.0		 5amjA-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.47A 5amjB-2zsiA:
undetectable		 5amjB-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 5 GLU B  54
THR B  72
HIS A  44
LEU A  34
 None
 1.28A 5axaC-2zsiB:
undetectable		 5axaC-2zsiB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2zsi DELLA PROTEIN GAI
PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		3 / 3 ASP B  28
VAL A  22
LEU B  80
 None
 0.64A 5e5jB-2zsiB:
undetectable		 5e5jB-2zsiB:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 5 ALA A 165
VAL A 169
PHE A 112
ILE A 185
 None
 1.04A 5of1A-2zsiA:
undetectable		 5of1A-2zsiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		4 / 7 ASN A 264
PRO A 265
PHE A 221
TRP A 294
 None
 1.46A 5oh3A-2zsiA:
0.0		 5oh3A-2zsiA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 ALA A 197
PHE A 112
GLY A 162
ILE A  70
LEU A 175
 None
 1.08A 5ul4A-2zsiA:
4.1		 5ul4A-2zsiA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 ALA A 122
GLY A 115
GLY A 162
ALA A 165
SER A 192
 None
GA4  A 345 (-3.1A)
None
None
None
 0.95A 5w4zA-2zsiA:
undetectable		 5w4zA-2zsiA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1
(Arabidopsis
thaliana) 		5 / 12 ALA A 122
GLY A 115
GLY A 162
ALA A 165
SER A 192
 None
GA4  A 345 (-3.1A)
None
None
None
 0.96A 5w4zB-2zsiA:
undetectable		 5w4zB-2zsiA:
12.57