SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_CUC1_0
(BETA-CARBONIC
ANHYDRASE)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 CYH A  84
SER A  86
SER A  91
ARG A 162
 None
 1.19A 1ekjC-2zsjA:
0.0
1ekjD-2zsjA:
0.0		 1ekjC-2zsjA:
22.10
1ekjD-2zsjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_CUE3_0
(BETA-CARBONIC
ANHYDRASE)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 CYH A  84
SER A  86
SER A  91
ARG A 162
 None
 1.35A 1ekjE-2zsjA:
0.0
1ekjF-2zsjA:
0.0		 1ekjE-2zsjA:
22.10
1ekjF-2zsjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_CUE3_0
(BETA-CARBONIC
ANHYDRASE)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 SER A  91
ARG A 162
CYH A  84
SER A  86
 None
 1.37A 1ekjE-2zsjA:
0.0
1ekjF-2zsjA:
0.0		 1ekjE-2zsjA:
22.10
1ekjF-2zsjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 TYR A 197
PRO A 181
LEU A 177
THR A  31
 None
 1.34A 1i2wA-2zsjA:
undetectable		 1i2wA-2zsjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 THR A  31
GLY A  29
GLY A 320
GLU A  54
GLY A  60
 None
None
PLP  A1101 (-3.5A)
None
None
 1.24A 1l5kA-2zsjA:
undetectable		 1l5kA-2zsjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 ARG A 162
GLY A  66
LYS A 167
THR A 168
 None
 1.24A 2m2oB-2zsjA:
undetectable		 2m2oB-2zsjA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		5 / 11 PHE A 201
VAL A 188
ILE A 186
PRO A 187
VAL A 314
 None
PLP  A1101 (-4.0A)
None
None
None
 1.36A 2vcdA-2zsjA:
undetectable		 2vcdA-2zsjA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 ARG A  65
GLY A  66
SER A 250
 None
 0.59A 2xctB-2zsjA:
undetectable		 2xctB-2zsjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 TYR A  53
PRO A  32
VAL A 286
GLY A 285
 None
 0.92A 3em0B-2zsjA:
undetectable		 3em0B-2zsjA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 PHE A  62
ILE A  34
LEU A  51
LYS A  52
 PLP  A1101 (-4.5A)
None
None
None
 1.15A 3sueC-2zsjA:
undetectable		 3sueC-2zsjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 4 ALA A  92
ALA A  95
ALA A  96
ALA A  99
 None
 0.10A 4oadA-2zsjA:
undetectable		 4oadA-2zsjA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 4 ALA A  92
ALA A  95
ALA A  96
ALA A  99
 None
 0.13A 4oaeA-2zsjA:
undetectable		 4oaeA-2zsjA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		4 / 5 GLY A 208
TYR A  14
TYR A 204
GLY A 200
 None
 1.00A 5ayfA-2zsjA:
undetectable		 5ayfA-2zsjA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 VAL A 152
LEU A 119
MET A 123
 None
 0.89A 5ikrA-2zsjA:
0.0		 5ikrA-2zsjA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 ALA A 294
ALA A 276
ALA A 297
ALA A 240
ASP A 270
 None
 1.08A 5l5zK-2zsjA:
undetectable
5l5zL-2zsjA:
undetectable		 5l5zK-2zsjA:
21.27
5l5zL-2zsjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 THR A 319
ALA A 276
ALA A 297
ALA A 240
ASP A 270
 PLP  A1101 (-3.0A)
None
None
None
None
 1.09A 5l5zK-2zsjA:
undetectable
5l5zL-2zsjA:
undetectable		 5l5zK-2zsjA:
21.27
5l5zL-2zsjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 ALA A 294
ALA A 276
ALA A 297
ALA A 240
ASP A 270
 None
 1.08A 5l5zY-2zsjA:
undetectable
5l5zZ-2zsjA:
undetectable		 5l5zY-2zsjA:
21.27
5l5zZ-2zsjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		5 / 9 THR A 319
ALA A 276
ALA A 297
ALA A 240
ASP A 270
 PLP  A1101 (-3.0A)
None
None
None
None
 1.10A 5l5zY-2zsjA:
undetectable
5l5zZ-2zsjA:
undetectable		 5l5zY-2zsjA:
21.27
5l5zZ-2zsjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2zsj THREONINE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 TRP A 219
ILE A 265
ASP A 266
 None
 0.64A 6i0y7-2zsjA:
undetectable		 6i0y7-2zsjA:
5.86