SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  38
PHE A  34
SER A  26
ILE A  25
ILE A   4
 None
 1.47A 1osvB-2zskA:
0.0		 1osvB-2zskA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 10 LEU A 191
ALA A 199
ILE A 157
LEU A 154
ILE A 158
 None
 1.11A 1yi4A-2zskA:
undetectable		 1yi4A-2zskA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		4 / 7 PHE A 210
GLU A 208
GLN A 202
GLU A 214
 None
 1.47A 2aowA-2zskA:
undetectable		 2aowA-2zskA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 9 LEU A 111
VAL A 115
VAL A 143
ILE A 190
VAL A 118
 None
 1.32A 2l8mA-2zskA:
undetectable		 2l8mA-2zskA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 THR A  15
VAL A 100
ALA A 213
VAL A  97
MET A  99
 None
 1.15A 3czhA-2zskA:
undetectable		 3czhA-2zskA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		4 / 8 GLY A 188
TYR A 180
LYS A 117
GLU A 184
 None
 0.86A 4hyfC-2zskA:
undetectable		 4hyfC-2zskA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		4 / 7 ASN A 155
GLU A 160
GLU A 161
GLU A 153
 None
 1.20A 4r87I-2zskA:
undetectable		 4r87I-2zskA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 9 PHE A  48
ILE A  61
GLY A   9
THR A  15
LEU A  69
 None
 1.33A 4ze0A-2zskA:
undetectable		 4ze0A-2zskA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 ALA A 107
PHE A  48
ILE A  61
GLY A   9
THR A  15
 None
 1.13A 5jlcA-2zskA:
undetectable		 5jlcA-2zskA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 2zsk 226AA LONG
HYPOTHETICAL
ASPARTATE RACEMASE
(Pyrococcus
horikoshii) 		5 / 12 PRO A 197
ILE A 102
ASP A 211
LEU A 191
THR A  10
 None
 1.31A 5tiwB-2zskA:
undetectable		 5tiwB-2zskA:
23.90