SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zsu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLU A 107
ASP A 144
GLY A 145
LEU A 172
 None
 0.68A 1jg2A-2zsuA:
8.0		 1jg2A-2zsuA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  86
GLU A 107
ASP A 144
GLY A 145
 None
 0.49A 1jg2A-2zsuA:
8.0		 1jg2A-2zsuA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 11 GLY A  84
GLY A  86
GLU A 107
ASP A 144
GLY A 145
LEU A 172
 None
 0.74A 1jg3A-2zsuA:
8.0		 1jg3A-2zsuA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 11 GLY A  84
GLY A  86
GLU A 107
ASP A 144
GLY A 145
LEU A 172
 None
 0.74A 1jg3B-2zsuA:
7.9		 1jg3B-2zsuA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 TYR A  10
HIS A  63
TYR A  62
GLY A  58
 AG3  A1001 (-4.9A)
AG3  A1001 (-4.0A)
AG3  A1001 (-4.5A)
None
 1.09A 1mxgA-2zsuA:
undetectable		 1mxgA-2zsuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A  86
GLY A  88
GLY A  89
HIS A  63
ASP A 109
VAL A 112
 None
None
None
AG3  A1001 (-4.0A)
None
None
 1.40A 1n2xB-2zsuA:
13.8		 1n2xB-2zsuA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  86
ILE A 108
ASP A 109
ASP A 144
 None
 0.58A 1qaoA-2zsuA:
9.3		 1qaoA-2zsuA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  85
GLY A  86
GLU A 107
ASP A 144
 None
AG3  A1001 ( 4.9A)
None
None
None
 0.74A 1qzzA-2zsuA:
12.5		 1qzzA-2zsuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A 185
ALA A 184
TYR A 191
LEU A 172
PHE A 148
 None
 1.21A 1s9pB-2zsuA:
undetectable		 1s9pB-2zsuA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLY A  88
GLY A  89
ILE A 108
ASP A 109
ASP A 144
GLY A 145
 None
 0.49A 1sqfA-2zsuA:
10.2		 1sqfA-2zsuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  85
GLY A  86
GLU A 107
ASP A 144
 None
AG3  A1001 ( 4.9A)
None
None
None
 0.76A 1xdsA-2zsuA:
11.3		 1xdsA-2zsuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  85
GLY A  86
GLU A 107
ASP A 144
 None
AG3  A1001 ( 4.9A)
None
None
None
 0.75A 1xdsB-2zsuA:
11.8		 1xdsB-2zsuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  84
GLU A 107
ASP A 161
 None
None
AG3  A1001 (-2.8A)
 0.59A 2b25B-2zsuA:
10.5		 2b25B-2zsuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  86
GLY A  89
ASP A 109
ASP A 144
LEU A 172
 None
 1.09A 2hmyB-2zsuA:
8.0		 2hmyB-2zsuA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 GLY A  86
ASP A  87
SER A 116
 None
AG3  A1001 (-3.0A)
None
 0.70A 2qhfA-2zsuA:
undetectable		 2qhfA-2zsuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A  84
GLU A 107
ILE A 108
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.72A 3a7eA-2zsuA:
12.9		 3a7eA-2zsuA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		8 / 12 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
GLN A 194
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
 0.49A 3b7pA-2zsuA:
37.5		 3b7pA-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		8 / 12 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
GLN A 194
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
 0.47A 3b7pB-2zsuA:
37.5		 3b7pB-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLN A  53
TYR A  62
HIS A  63
GLU A 204
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
AG3  A1001 (-3.7A)
 0.96A 3b7pB-2zsuA:
37.5		 3b7pB-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ASP A  87
ASP A 161
ASP A 164
GLU A 204
SER A 197
 AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
None
None
 1.20A 3b7pC-2zsuA:
37.8		 3b7pC-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		8 / 12 GLN A  53
TYR A  62
HIS A  63
ASP A  87
ASP A 161
ASP A 164
SER A 197
TYR A 229
 AG3  A1001 (-3.2A)
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.0A)
None
AG3  A1001 (-3.7A)
 0.60A 3b7pC-2zsuA:
37.8		 3b7pC-2zsuA:
36.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLN A  32
TYR A  62
GLY A  85
ASP A 109
VAL A 112
GLN A 194
 None
AG3  A1001 (-4.5A)
AG3  A1001 ( 4.9A)
None
None
AG3  A1001 ( 4.1A)
 1.22A 3bwcA-2zsuA:
33.0		 3bwcA-2zsuA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		11 / 12 GLN A  32
TYR A  62
HIS A  63
ILE A  83
GLY A  84
ILE A 108
ASP A 109
VAL A 112
ASP A 144
GLY A 145
GLN A 194
 None
AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
None
None
None
None
None
None
AG3  A1001 ( 4.1A)
 0.63A 3bwcA-2zsuA:
33.0		 3bwcA-2zsuA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  62
HIS A  63
ILE A  83
GLY A  84
ASP A  87
ILE A 108
ASP A 109
VAL A 112
GLY A 145
ASP A 161
 AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
None
AG3  A1001 (-3.0A)
None
None
None
None
AG3  A1001 (-2.8A)
 0.39A 3bwcB-2zsuA:
32.6		 3bwcB-2zsuA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		10 / 12 TYR A  62
HIS A  63
ILE A  83
GLY A  84
ILE A 108
ASP A 109
VAL A 112
GLY A 145
ASP A 161
GLN A 194
 AG3  A1001 (-4.5A)
AG3  A1001 (-4.0A)
None
None
None
None
None
None
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
 0.61A 3bwcB-2zsuA:
32.6		 3bwcB-2zsuA:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mA-2zsuA:
26.0		 3c6mA-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		7 / 11 VAL A  52
TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.3A)
AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.60A 3c6mA-2zsuA:
26.0		 3c6mA-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mB-2zsuA:
25.9		 3c6mB-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 9 TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.57A 3c6mB-2zsuA:
25.9		 3c6mB-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 10 ASP A 164
TYR A  62
ASP A 161
TYR A 229
TRP A 233
 AG3  A1001 (-3.0A)
AG3  A1001 (-4.5A)
AG3  A1001 (-2.8A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 1.09A 3c6mC-2zsuA:
25.9		 3c6mC-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		7 / 10 VAL A  52
TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.3A)
AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.59A 3c6mC-2zsuA:
25.9		 3c6mC-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 10 TYR A  62
ASP A  87
ASP A 161
GLN A 194
TYR A 229
TRP A 233
 AG3  A1001 (-4.5A)
AG3  A1001 (-3.0A)
AG3  A1001 (-2.8A)
AG3  A1001 ( 4.1A)
AG3  A1001 (-3.7A)
AG3  A1001 (-4.9A)
 0.58A 3c6mD-2zsuA:
25.9		 3c6mD-2zsuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  86
ILE A 108
ASP A 109
LEU A 172
 None
 0.79A 3cjtG-2zsuA:
12.7		 3cjtG-2zsuA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLY A  86
ILE A 108
ASP A 109
LEU A 172
 None
 0.76A 3cjtO-2zsuA:
12.9		 3cjtO-2zsuA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 GLY A  84
GLU A 107
ILE A 108
ASP A 109
ASP A 144
 None
 0.32A 3grvA-2zsuA:
9.7		 3grvA-2zsuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  84
GLU A 107
ILE A 108
ASP A 109
ASP A 144
 None
 0.38A 3gryA-2zsuA:
11.8		 3gryA-2zsuA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
ASP A 109
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.80A 3m6vA-2zsuA:
10.6		 3m6vA-2zsuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
ASP A 109
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.80A 3m6vB-2zsuA:
10.7		 3m6vB-2zsuA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 GLY A  84
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.62A 3mb5A-2zsuA:
14.3		 3mb5A-2zsuA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 TYR A 191
GLY A 189
ALA A  70
ASP A 156
VAL A 157
 None
 1.23A 3nvkF-2zsuA:
undetectable
3nvkJ-2zsuA:
12.8		 3nvkF-2zsuA:
21.63
3nvkJ-2zsuA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 GLY A  86
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.70A 3vywC-2zsuA:
15.8		 3vywC-2zsuA:
27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_A_QMRA1214_1
(CAPITELLA TELETA
ACHBP)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A 192
TYR A 178
ILE A 190
ILE A 158
PHE A 177
 None
 1.18A 4afgA-2zsuA:
0.0
4afgB-2zsuA:
0.0		 4afgA-2zsuA:
19.93
4afgB-2zsuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 ILE A 190
ILE A 158
PHE A 177
VAL A 192
TYR A 178
 None
 1.07A 4afgA-2zsuA:
0.0
4afgE-2zsuA:
0.0		 4afgA-2zsuA:
19.93
4afgE-2zsuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 8 VAL A 192
TYR A 178
ILE A 190
ILE A 158
 None
 0.87A 4afgD-2zsuA:
undetectable
4afgE-2zsuA:
undetectable		 4afgD-2zsuA:
19.93
4afgE-2zsuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A 192
TYR A 178
ILE A 190
ILE A 158
PHE A 177
 None
 1.14A 4afgC-2zsuA:
0.0
4afgD-2zsuA:
0.0		 4afgC-2zsuA:
19.93
4afgD-2zsuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 9 VAL A 192
TYR A 178
ILE A 190
ILE A 158
PHE A 177
 None
 1.14A 4afgB-2zsuA:
0.0
4afgC-2zsuA:
0.0		 4afgB-2zsuA:
19.93
4afgC-2zsuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 6 HIS A  63
GLU A 107
ASP A 144
ASP A 161
 AG3  A1001 (-4.0A)
None
None
AG3  A1001 (-2.8A)
 1.19A 4blvA-2zsuA:
12.1		 4blvA-2zsuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  84
ILE A 108
GLY A 143
ILE A 142
 None
 0.66A 4eatA-2zsuA:
2.3		 4eatA-2zsuA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9A-2zsuA:
11.0		 4fp9A-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9C-2zsuA:
10.9		 4fp9C-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
ASP A 144
GLY A 145
LEU A 172
 None
 0.62A 4fp9D-2zsuA:
11.0		 4fp9D-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.88A 4fp9F-2zsuA:
10.9		 4fp9F-2zsuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  88
GLY A  89
ASP A 144
GLY A 145
LEU A 172
 None
 0.59A 4fzvA-2zsuA:
10.8		 4fzvA-2zsuA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		3 / 3 GLU A 107
ASP A 109
ASP A 144
 None
 0.20A 4gc9A-2zsuA:
10.2		 4gc9A-2zsuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 GLU A   8
VAL A  16
VAL A  55
PHE A  18
 AG3  A1001 (-3.2A)
None
None
None
 0.95A 4lb0B-2zsuA:
undetectable		 4lb0B-2zsuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 LEU A  46
LEU A  54
ILE A 120
ASP A 123
GLY A  86
 None
AG3  A1001 ( 4.9A)
None
None
None
 1.02A 4lmnA-2zsuA:
undetectable		 4lmnA-2zsuA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 5 SER A 116
GLU A  59
LYS A  60
ASP A 123
 None
 1.06A 4pclA-2zsuA:
13.0		 4pclA-2zsuA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 4 ILE A 149
ASN A 152
ILE A 141
VAL A 106
 None
 1.21A 4uy87-2zsuA:
undetectable		 4uy87-2zsuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 11 SER A 162
SER A 174
LYS A 211
ASP A 144
GLY A 145
 None
 1.24A 4zjqA-2zsuA:
0.7		 4zjqA-2zsuA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  84
GLU A 107
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.77A 5ergB-2zsuA:
10.4		 5ergB-2zsuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		4 / 7 GLY A  84
GLY A  86
ASP A 144
ASP A 161
 None
None
None
AG3  A1001 (-2.8A)
 0.67A 5ergB-2zsuA:
10.4		 5ergB-2zsuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLN A  32
LEU A 172
VAL A 160
TYR A  62
GLY A  85
 None
None
None
AG3  A1001 (-4.5A)
AG3  A1001 ( 4.9A)
 1.35A 5i8fA-2zsuA:
undetectable		 5i8fA-2zsuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  89
ASP A 144
GLY A 145
ASP A 161
LEU A 172
 None
None
None
AG3  A1001 (-2.8A)
None
 0.97A 5wwsA-2zsuA:
9.8		 5wwsA-2zsuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		7 / 12 GLN A  32
GLY A  84
ILE A 108
ASP A 109
VAL A 112
ASP A 144
LEU A 172
 None
 0.77A 6bq4A-2zsuA:
35.3		 6bq4A-2zsuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLN A  32
GLY A  84
ASP A 109
VAL A 112
ALA A 169
 None
 1.03A 6bq4B-2zsuA:
35.6		 6bq4B-2zsuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLN A  32
GLY A  84
ILE A 108
ASP A 109
VAL A 112
ASP A 144
 None
 0.48A 6bq4B-2zsuA:
35.6		 6bq4B-2zsuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		6 / 12 GLN A  32
ILE A 108
ASP A 109
VAL A 112
ASP A 144
PRO A 168
 None
 0.68A 6bq4B-2zsuA:
35.6		 6bq4B-2zsuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 GLY A  85
SER A  29
GLN A  32
ILE A 108
ASP A 144
 AG3  A1001 ( 4.9A)
None
None
None
None
 1.24A 6bxnB-2zsuA:
2.7		 6bxnB-2zsuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2zsu SPERMIDINE SYNTHASE
(Pyrococcus
horikoshii) 		5 / 12 ILE A  83
GLY A  84
GLY A  86
ILE A 108
ASP A 109
 None
 0.51A 6iftA-2zsuA:
10.2		 6iftA-2zsuA:
22.53