SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2zts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		5 / 12 ILE A 198
ILE A 157
ILE A 147
VAL A  97
ILE A 127
 None
 0.92A 1oipA-2ztsA:
2.3		 1oipA-2ztsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.71A 1v55N-2ztsA:
undetectable
1v55W-2ztsA:
undetectable		 1v55N-2ztsA:
17.81
1v55W-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 5 PHE A  64
PHE A  85
MET A  78
SER A  80
 None
None
None
ADP  A1903 (-2.6A)
 1.23A 1wrlC-2ztsA:
undetectable		 1wrlC-2ztsA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		3 / 3 SER A 190
VAL A 202
LEU A  34
 None
 0.75A 1yajG-2ztsA:
undetectable		 1yajG-2ztsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.70A 2eijN-2ztsA:
undetectable
2eijW-2ztsA:
undetectable		 2eijN-2ztsA:
17.81
2eijW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.74A 2eikN-2ztsA:
undetectable
2eikW-2ztsA:
undetectable		 2eikN-2ztsA:
17.81
2eikW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.72A 2eilN-2ztsA:
undetectable
2eilW-2ztsA:
undetectable		 2eilN-2ztsA:
17.81
2eilW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.76A 2einA-2ztsA:
undetectable
2einJ-2ztsA:
undetectable		 2einA-2ztsA:
17.81
2einJ-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 7 ILE A 198
ILE A 127
LEU A 124
ILE A 167
 None
 0.83A 2q83A-2ztsA:
undetectable		 2q83A-2ztsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 7 LEU A 161
GLU A 195
ILE A 147
ILE A  96
 None
 0.82A 2xkwA-2ztsA:
undetectable		 2xkwA-2ztsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		5 / 12 LEU A  35
ILE A 176
PRO A  61
ILE A  94
PHE A  85
 None
 0.93A 2ygqA-2ztsA:
undetectable		 2ygqA-2ztsA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.72A 3abkA-2ztsA:
undetectable
3abkJ-2ztsA:
undetectable		 3abkA-2ztsA:
17.81
3abkJ-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.72A 3ablN-2ztsA:
undetectable
3ablW-2ztsA:
undetectable		 3ablN-2ztsA:
17.81
3ablW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.69A 3abmN-2ztsA:
undetectable
3abmW-2ztsA:
undetectable		 3abmN-2ztsA:
17.81
3abmW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.69A 3ag3N-2ztsA:
undetectable
3ag3W-2ztsA:
undetectable		 3ag3N-2ztsA:
17.81
3ag3W-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.72A 3asnN-2ztsA:
undetectable
3asnW-2ztsA:
undetectable		 3asnN-2ztsA:
17.81
3asnW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.69A 3asoN-2ztsA:
undetectable
3asoW-2ztsA:
undetectable		 3asoN-2ztsA:
17.81
3asoW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		3 / 3 THR A  36
VAL A 202
GLU A 195
 None
 0.71A 3v4tA-2ztsA:
undetectable
3v4tD-2ztsA:
undetectable		 3v4tA-2ztsA:
22.38
3v4tD-2ztsA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 7 PRO A  17
ILE A  16
GLN A  49
GLY A 241
 None
 1.00A 4a3uB-2ztsA:
3.1		 4a3uB-2ztsA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 6 ARG A 150
ASP A  73
GLU A  89
LEU A  67
 None
 1.35A 4ax8A-2ztsA:
3.8		 4ax8A-2ztsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		5 / 9 ALA A  55
GLY A  54
ILE A  51
GLY A  62
ILE A  94
 None
 1.09A 4eatB-2ztsA:
2.3		 4eatB-2ztsA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		3 / 3 LYS A 163
ILE A 194
THR A  32
 None
 0.87A 4gh8A-2ztsA:
undetectable		 4gh8A-2ztsA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 7 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.67A 5b1bN-2ztsA:
undetectable
5b1bW-2ztsA:
undetectable		 5b1bN-2ztsA:
17.81
5b1bW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 7 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.67A 5b3sN-2ztsA:
undetectable
5b3sW-2ztsA:
undetectable		 5b3sN-2ztsA:
17.81
5b3sW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 6 PHE A 235
ARG A 216
THR A  45
ILE A 237
 None
ADP  A1903 (-4.0A)
ADP  A1903 (-3.7A)
ADP  A1903 (-3.8A)
 1.38A 5ih0A-2ztsA:
undetectable		 5ih0A-2ztsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 7 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.70A 5iy5N-2ztsA:
undetectable
5iy5W-2ztsA:
undetectable		 5iy5N-2ztsA:
17.81
5iy5W-2ztsA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 4 GLU A  68
THR A  66
THR A 175
LEU A 164
 MG  A1904 ( 4.7A)
None
None
None
 1.37A 5v96A-2ztsA:
undetectable		 5v96A-2ztsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 4 GLU A  68
THR A  66
THR A 175
LEU A 164
 MG  A1904 ( 4.7A)
None
None
None
 1.39A 5v96B-2ztsA:
undetectable		 5v96B-2ztsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 4 GLU A  68
THR A  66
THR A 175
LEU A 164
 MG  A1904 ( 4.7A)
None
None
None
 1.37A 5v96C-2ztsA:
undetectable		 5v96C-2ztsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 4 GLU A  68
THR A  66
THR A 175
LEU A 164
 MG  A1904 ( 4.7A)
None
None
None
 1.37A 5v96D-2ztsA:
undetectable		 5v96D-2ztsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.66A 5xdxN-2ztsA:
undetectable
5xdxW-2ztsA:
undetectable		 5xdxN-2ztsA:
17.81
5xdxW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.70A 5zcoA-2ztsA:
undetectable
5zcoJ-2ztsA:
undetectable		 5zcoA-2ztsA:
17.81
5zcoJ-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.72A 5zcpN-2ztsA:
undetectable
5zcpW-2ztsA:
undetectable		 5zcpN-2ztsA:
17.81
5zcpW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186
(Pyrococcus
horikoshii) 		4 / 8 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.70A 5zcqN-2ztsA:
undetectable
5zcqW-2ztsA:
undetectable		 5zcqN-2ztsA:
17.81
5zcqW-2ztsA:
12.50