SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ztu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 12 GLY A  48
ASN A  90
ILE A 140
GLY A 232
ILE A  20
 None
NAD  A 300 (-3.2A)
None
None
None
 1.22A 1q8jB-2ztuA:
2.4		 1q8jB-2ztuA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 9 ALA A  62
ASN A  34
LEU A  73
GLY A  72
GLY A 121
 None
NAD  A 300 (-3.7A)
None
None
None
 1.18A 1ru9H-2ztuA:
undetectable
1ru9L-2ztuA:
undetectable		 1ru9H-2ztuA:
21.82
1ru9L-2ztuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 10 ALA A  62
ASN A  34
LEU A  73
GLY A  72
GLY A 121
 None
NAD  A 300 (-3.7A)
None
None
None
 1.19A 1ruaH-2ztuA:
undetectable
1ruaL-2ztuA:
undetectable		 1ruaH-2ztuA:
21.82
1ruaL-2ztuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 9 ALA A  62
ASN A  34
LEU A  73
GLY A  72
GLY A 121
 None
NAD  A 300 (-3.7A)
None
None
None
 1.21A 1rulH-2ztuA:
undetectable
1rulL-2ztuA:
undetectable		 1rulH-2ztuA:
21.82
1rulL-2ztuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 12 ALA A 235
LEU A 238
ALA A 239
PHE A 134
ILE A 178
 None
 1.28A 2jjpA-2ztuA:
undetectable		 2jjpA-2ztuA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 9 GLY A  19
ILE A 183
THR A 166
VAL A  88
VAL A 118
 None
 1.02A 2nnhB-2ztuA:
undetectable		 2nnhB-2ztuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		4 / 8 ILE A  16
ILE A  20
ARG A 136
ALA A   7
 NAD  A 300 (-3.8A)
None
None
None
 0.66A 2nniA-2ztuA:
undetectable		 2nniA-2ztuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		4 / 7 ILE A 137
ILE A  31
LEU A 126
LEU A  73
 None
 0.89A 3adxA-2ztuA:
undetectable		 3adxA-2ztuA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		4 / 4 THR A 122
VAL A 162
GLY A 248
THR A 249
 None
 1.00A 3cflA-2ztuA:
undetectable		 3cflA-2ztuA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 12 THR A  10
VAL A 162
GLY A 161
LEU A 113
ILE A  93
 None
None
None
NAD  A 300 (-4.6A)
None
 0.99A 3ijdA-2ztuA:
2.4		 3ijdA-2ztuA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 11 TYR A 155
ILE A 110
GLY A  92
ALA A  91
VAL A  70
 NAD  A 300 (-4.3A)
None
NAD  A 300 (-3.6A)
NAD  A 300 ( 4.0A)
None
 1.18A 3rukD-2ztuA:
undetectable		 3rukD-2ztuA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 12 GLY A 233
VAL A 251
ALA A 239
LEU A 238
ALA A 243
 None
 0.94A 5kpcA-2ztuA:
5.2		 5kpcA-2ztuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 12 VAL A  45
GLY A  48
ALA A  50
ASN A  90
VAL A   9
 None
None
None
NAD  A 300 (-3.2A)
None
 1.12A 6bqgA-2ztuA:
undetectable		 6bqgA-2ztuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 9 VAL A  57
VAL A   9
LEU A  49
GLY A  19
LEU A  18
 None
 1.16A 6czmB-2ztuA:
undetectable
6czmC-2ztuA:
undetectable		 6czmB-2ztuA:
23.24
6czmC-2ztuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 9 VAL A  57
VAL A   9
LEU A  49
GLY A  19
LEU A  18
 None
 1.17A 6czmD-2ztuA:
undetectable
6czmE-2ztuA:
undetectable		 6czmD-2ztuA:
23.24
6czmE-2ztuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE
(Pseudomonas
fragi) 		5 / 10 VAL A  57
VAL A   9
LEU A  49
GLY A  19
LEU A  18
 None
 1.16A 6czmE-2ztuA:
undetectable
6czmF-2ztuA:
undetectable		 6czmE-2ztuA:
23.24
6czmF-2ztuA:
23.24